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The extraction of pure bromelain from pineapples involves a sophisticated process that employs various techniques to isolate this valuable enzyme. These methods play a crucial role in obtaining high-quality bromelain with efficiency and precision.
Ion exchange chromatography stands out as one of the most widely employed techniques for bromelain isolation. In this method, the separation is achieved based on the charge of the proteins, utilizing the differences in their ionic properties. The process facilitates the isolation of bromelain by exploiting its unique charge characteristics, ensuring a purified form of the enzyme.
Another common method in bromelain isolation is salt precipitation. This technique utilizes membranes that selectively separate proteins within a specific molecular mass range, typically between 3 kiloDalton (kDa) to 100 kDa. The process is conducted at low temperatures and involves the use of polyethylene glycol (PEG) in conjunction with potassium phosphate, ammonium sulfate, or magnesium sulfate. The controlled precipitation and subsequent separation contribute to the purity of the extracted bromelain.
Aqueous two-phase systems represent a sophisticated approach to bromelain extraction. This method involves the formation of two immiscible phases within an aqueous system, achieved by mixing a polymer with salt or by combining two incompatible polymers. The extraction efficiency is influenced by factors such as pH, molecular weight of the polymers, ionic strength, and the type of salt used. Aqueous two-phase systems offer a precise and controlled environment for the extraction process.
Adsorption processes, involving the binding of solutes to solid surfaces, provide another avenue for bromelain separation. In modern extraction techniques, nanoparticles serve as effective adsorbents in purifying enzymes. Nanoparticles offer a high surface area and tailored properties that enhance the efficiency of the adsorption process, contributing to the overall purification of bromelain.
Reverse micelle extraction represents a liquid-liquid technique aided by downstream processing. In this method, an organic phase is separated from an aqueous phase using surfactants, creating a system where bromelain can be selectively extracted. The use of reverse micelle extraction contributes to the precision of the separation process.
Column chromatography is a versatile technique that plays a significant role in biomolecule separation, including proteins like bromelain. This method relies on the interaction of biomolecules with the stationary and mobile phases within the column, separating proteins based on charge, molecular size, ligand affinity, and other characteristics.
The combination of aqueous two-phase systems and reverse micelle systems enhances the efficiency of bromelain extraction. This synergistic approach not only increases output but also minimizes wastage, contributing to a more sustainable and cost-effective extraction process.
The integration of advanced technologies in enzyme extraction, as seen in these sophisticated methods, is poised to have a profound impact on the bromelain market. The use of these techniques is expected to streamline the extraction process, leading to a reduction in the overall cost of bromelain production. As a result, the market is anticipated to witness substantial growth, driven by the increased accessibility and affordability of this valuable enzyme.
Covered Aspects:
| Report Attribute/Metric | Details |
|---|---|
| Market Opportunities | Growing use of bromelain in various industries |
| Market Dynamics | Increasing demand for natural and plant-based products |
Bromelain Market Highlights:
Global Bromelain Market Overview
Bromelain Market Size was valued at USD 0.9 billion in 2022. The Bromelain industry is projected to grow from USD 0.93951 Billion in 2023 to USD 1.21 billion by 2030, exhibiting a compound annual growth rate (CAGR) of 4.39% during the forecast period (2023 - 2030). Increasing demand for natural and plant-based products, and growing use of bromelain in the various industry are the key market drivers enhancing the market growth.
Source: Secondary Research, Primary Research, MRFR Database and Analyst Review
Bromelain Market Trends
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Increasing demand for natural and plant-based products to boost market growth
The increasing demand for natural and plant-based products is one of the key drivers of the bromelain market. Consumers are becoming more health-conscious and are looking for natural alternatives to traditional medicines, which is driving the demand for natural ingredients like bromelain. As a natural and plant-based product, bromelain is increasingly being used in various health supplements and medicines due to its anti-inflammatory and digestive properties. This trend towards natural and plant-based products is expected to continue to drive the demand for bromelain in the market.
The growing use of bromelain in the food and beverage industry driving market growth during the forecast period. Bromelain is used as a meat tenderizer, in beer production, and as a food preservative due to its ability to break down proteins. With the rising demand for processed foods and beverages, the demand for bromelain is expected to increase.
Moreover, the increasing use of bromelain in the cosmetics industry is expected to drive the market growth. Bromelain is used in various skin care products due to its exfoliating and anti-inflammatory properties. The rising demand for natural and organic cosmetics is expected to increase the demand for bromelain.
Bromelain Market Segment Insights
Bromelain Source Insights
The bromelain market data has been bifurcated by source into stem, and fruits. The fruits source segment dominated the market in 2022 and is projected to be the faster-growing segment during the forecast period, 2022-2030. This is attributed to its higher bromelain content. Fruit bromelain is extracted from the fruit of the pineapple plant. It has a lower enzymatic activity compared to stem bromelain but is used in various cosmetic applications due to its exfoliating and anti-inflammatory properties.
Bromelain Type Insights
The Bromelain market segmentation, based on type, includes 1200 GDU/g, 2000 GDU/g, 2500 GDU/g, and others. The 2500 GDU/g bromelain segment held the majority share in 2022 contribution to the Bromelain market revenue. This is due to the high potency of bromelain and is typically used in pharmaceutical applications for its anti-inflammatory and pain-relieving properties. The selection of the appropriate type of bromelain is dependent on the specific activity or potency required for the intended application.
Bromelain Application Insights
The Bromelain market segmentation, based on application, includes healthcare, dietary supplements, food & beverages, and others. The dietary supplements segment dominated the market in 2022 and is projected to be the faster-growing segment during the forecast period, 2022-2030. This is attributed to the high purchasing power and increasing health awareness of the consumers in the developing economies. The use of bromelain in dietary supplements is increasing due to its anti-inflammatory and digestive properties, while in the food and beverage industry, it is used as a meat tenderizer, in beer production, and as a food preservative. Hence, rising applications of dietary supplements for bromelain positively impacts the market growth.
Figure 1: Bromelain Market, by Application, 2022 & 2030 (USD Billion)
Source: Secondary Research, Primary Research, MRFR Database and Analyst Review
Bromelain Regional Insights
By Region, the study provides the market insights into North America, Europe, Asia-Pacific and Rest of the World. North America Bromelain market accounted for USD 0.41 billion in 2022 and is expected to exhibit a significant CAGR growth during the study period. This is attributed to the high demand for dietary supplements and natural products. The increasing awareness among consumers regarding the health benefits of bromelain is expected to drive the market growth in the region. Moreover, use of bromelain in various industries including food and beverage, pharmaceuticals, and cosmetics is expected to drive the market growth in the regions.
Further, the major countries studied in the market report are: The U.S, Canada, Germany, France, UK, Italy, Spain, China, Japan, India, Australia, South Korea, and Brazil.
Figure 2: BROMELAIN MARKET SHARE BY REGION 2022 (%)
Source: Secondary Research, Primary Research, MRFR Database and Analyst Review
Europe Bromelain market accounts for the second-largest market share due to the increasing use of bromelain in food and beverage and cosmetic industries. The demand for natural and plant-based ingredients is also driving the market growth in the region. Further, the Germany Bromelain market held the largest market share, and the UK Bromelain market was the fastest growing market in the European region
The Asia-Pacific Bromelain Market is expected to grow at the fastest CAGR from 2022 to 2030. The Asia-Pacific Bromelain market is driven by the growth of the bakery and confectionery industries. This is due to the increasing demand for bromelain in the food and beverage industry. The use of bromelain as a meat tenderizer and in beer production is driving the market growth in the region. Moreover, China Bromelain market held the largest market share, and the India Bromelain market was the fastest growing market in the Asia-Pacific region
Bromelain Key Market Players & Competitive Insights
Major market players are spending a lot of money on R&D to increase their product lines, which will help the Bromelain market grow even more. Market participants are also taking a range of strategic initiatives to grow their worldwide footprint, with key market developments such as new product launches, contractual agreements, mergers and acquisitions, increased investments, and collaboration with other organizations. Competitors in the Bromelain industry must offer cost-effective items to expand and survive in an increasingly competitive and rising market environment.
One of the primary business strategies adopted by manufacturers in the Bromelain industry to benefit clients and expand the market sector is to manufacture locally to reduce operating costs. In recent years, Bromelain industry has provided innovative products with some of the most significant benefits. The Bromelain market major player such as Enzybel Group (Belgium), Changsha Natureway Co. Ltd. (China), Nutriteck (Canada), Enzyme Development Corporation (U.S.), Fooding Group Limited (China), Krishna Enzytech Pvt. Ltd. (India), Creative Enzymes (U.S.), Hong Mao Biochemicals Co. Ltd. (Thailand), Food State Company (U.K.), Advanced Enzyme Technologies (India) and others are working to expand the market demand by investing in research and development activities.
Enzybel Group is a Belgium-based company that specializes in the production of plant-derived enzymes for various applications, including food and beverage, pharmaceuticals, and cosmetics. The company's product portfolio includes a range of enzymes, including bromelain, papain, and ficin. The company operates globally, with production facilities in Belgium, Brazil, and China. In August 2021, Enzybel Group announced the launch of its new bromelain product, Bromelain K, which has been developed specifically for the food industry. The new product is a high-quality and stable bromelain enzyme that can be used as a meat tenderizer, protein hydrolyzer, and flavor enhancer in various food applications.
Enzyme Development Corporation (EDC) is a biotech company that specializes in the development and production of enzymes for various industries, including food, pharmaceuticals, and agriculture. EDC has been in operation for over 40 years and has become a leader in the enzyme industry due to its innovative products and exceptional customer service. One notable product in EDC's portfolio is bromelain, an enzyme derived from pineapple stems that has been shown to have anti-inflammatory and digestive benefits. Bromelain is commonly used as a dietary supplement and in the food industry as a meat tenderizer. In July 2022, EDC announced that it had completed a clinical trial on the effectiveness of its bromelain product in reducing joint pain and inflammation in patients with osteoarthritis. The results of the trial were promising, showing a significant reduction in pain and stiffness in the participants who received the bromelain supplement compared to the placebo group..
Key Companies in the Bromelain market includes
- Enzybel Group (Belgium)
- Changsha Natureway Co. Ltd. (China)
- Nutriteck (Canada)
- Enzyme Development Corporation (U.S.)
- Fooding Group Limited (China)
- Krishna Enzytech Pvt. Ltd. (India)
- Creative Enzymes (U.S.)
- Hong Mao Biochemicals Co. Ltd. (Thailand)
- Food State Company (U.K.)
- Advanced Enzyme Technologies (India)
Bromelain Industry Developments
Enzyme Technology (PTY) Ltd recently introduced organic bromelain products that meet international requirements.
Enzybel Group:encapsulated bromelain was added for more focused delivery and stability.
June 2022:Â US-based company Thorne HealthTech launched a new bromelain supplement. The supplement is marketed as a natural anti-inflammatory agent and digestive aid.
June 2020: US-based company Enzymedica launched a new product line called Enzyme Science, which includes a bromelain supplement. The supplement is marketed as a digestive aid and anti-inflammatory agent.
2021: the Chinese company Hubei YuanCheng GongChuang Technology Co., Ltd. launched a new bromelain product. The product is marketed as a natural plant-based enzyme with anti-inflammatory and digestive properties.
September 2021: US-based company Now Foods partnered with the Brazilian company Amazonia Bio to source sustainably harvested bromelain from the Amazon rainforest. The partnership aims to promote sustainable and ethical sourcing of natural ingredients, including bromelain.
March 2019: German company Martin Bauer Group acquired BI Nutraceuticals, a US-based supplier of plant-based ingredients, including bromelain. The acquisition strengthened Martin Bauer Group's position in the natural ingredients market, including the bromelain market.
Bromelain Market Segmentation
Bromelain Source Outlook
- Stem
- Fruits
Bromelain Type Outlook
- 1200 GDU/g
- 2000 GDU/g
- 2500 GDU/g
- Others
Bromelain Application Outlook
- Healthcare
- Dietary Supplements
- Food & Beverages
- Others
Bromelain Regional Outlook
-
North America- US
- Canada
-
Europe- Germany
- France
- UK
- Italy
- Spain
- Rest of Europe
-
Asia-Pacific- China
- Japan
- India
- Australia
- South Korea
- Australia
- Rest of Asia-Pacific
-
Rest of the World- Middle East
- Africa
- Latin America
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