Introduction: Navigating the Future of Organ-On-a-Chip Technology
The competition in organ-on-chip technology is growing rapidly, driven by a rapid increase in technology adoption, changes in regulatory frameworks and rising patient expectations for precision medicine. The leading players in the market, including leading equipment manufacturers, IT system integrators and a number of small, agile artificial intelligence companies, are now competing to develop advanced capabilities such as machine learning-based data analysis and automation to increase the efficiency of research and patient outcomes. These companies are now being joined by a number of new entrants, including service and platform companies, whose focus is on IoT integration and biometrics to create a seamless data-driven environment. The technological differentiation of the market is changing, and the strategic deployment of the market is particularly influenced by regulatory support in North America and Europe. These are the key considerations for C-levels and strategic planners who want to make the most of the transformational potential of organ-on-chip solutions in the coming years.
Competitive Positioning
Full-Suite Integrators
These suppliers offer a wide range of integrated organ-on-a-chip systems for advanced research applications.
Vendor | Competitive Edge | Solution Focus | Regional Focus |
Emulate, Inc. (US) |
Leading in organ-chip technology integration |
Organ-on-a-chip platforms |
North America, Europe |
MIMETAS BV (Netherlands) |
Innovative 3D organ models |
Organ-on-a-chip systems |
Europe, North America |
Specialized Technology Vendors
These companies are specialized in the organ-on-a-chip market.
Vendor | Competitive Edge | Solution Focus | Regional Focus |
TissUse GmbH (Germany) |
Unique multi-organ chip technology |
Multi-organ systems |
Europe, Asia |
H碌rel Corporation |
Advanced microfluidic technology |
Microfluidic organ-on-a-chip |
North America |
InSphero (Switzerland) |
Expertise in 3D cell culture |
3D cell culture systems |
Europe, North America |
TARA Biosystems, Inc. (US) |
Cardiac tissue modeling expertise |
Cardiac organ-on-a-chip |
North America |
Axosim (US) |
Focus on neural models |
Neural organ-on-a-chip |
North America |
Organovo Holdings Inc. (US) |
Pioneering bioprinting technology |
Bioprinted tissues |
North America |
Infrastructure & Equipment Providers
These suppliers provide the essential equipment and platforms for organ-on-chip research.
Vendor | Competitive Edge | Solution Focus | Regional Focus |
CN Bio Innovations Limited (UK) |
Robust platform for drug testing |
Organ-on-a-chip devices |
Europe, North America |
Nortis, Inc. (US) |
Innovative vascularized tissue models |
Vascularized organ models |
North America |
BioIVT (US) |
Specialized in biological samples |
Biological sample provision |
North America |
HemoShear Therapeutics, LLC (US) |
Expertise in human-relevant models |
Human tissue models |
North America |
Emerging Players & Regional Champions
- Emulate, Inc. (U.S.A.): a company specializing in human organ-on-a-chip technology for drug-testing and modeling of diseases. Challenges the established suppliers by providing more accurate, human-like data.
- Mimetas (Netherlands) focuses on the development of organ-on-a-chip platforms for drug discovery and pharmacological characterization. Their OrganoPlate platform has recently been implemented in several European research institutions, thereby complementing the established suppliers of organ-on-a-chip technology with a high-throughput, scalable and reproducible solution.
- TissUse (Germany): a multi-organ chip platform for studying the effects of drugs on various organ systems. It has just collaborated with a biotech company in a project on individualized medicine. Its goal is to challenge the established in vitro testing methods.
- CN Bio Innovations, United Kingdom, develops human-like organ-on-a-chip systems for drug testing and development. Recently it signed a contract with a leading CRO to expand its capabilities in drug testing, complementing established suppliers with solutions tailored to specific applications.
Regional Trends: In 2024, there is a noticeable increase in the use of organ-on-a-chip technology in Europe and North America, a result of a growing regulatory pressure for more human-like testing methods. The companies that provide these chips are becoming more specialized, focusing on specific applications, such as pharmacovigilance, disease modeling and regenerative medicine, which has led to a more competitive landscape, where new entrants are challenging the established players with their more bespoke and creative solutions.
Collaborations & M&A Movements
- Emulate and AstraZeneca have signed an agreement to use organ-on-chip technology in drug development. The aim is to increase the efficiency of preclinical testing and reduce the time to market for new medicines.
- Roche and Mimetas announced a strategic partnership to develop advanced organ-on-a-chip models for precision medicine applications. This is expected to further strengthen Roche鈥檚 position in the precision medicine market.
- In the early part of 2024, Charles River Laboratories acquired the TissUse company, which was to provide them with in vitro testing solutions and thus strengthen their position in the biopharmaceutical sector.
Competitive Summary Table
Capability | Leading Players | Remarks |
Cell Culture and Maintenance |
Emulate, Inc., Mimetas |
The technology of organs-on-chips provides for a more precise environment for cell culture, allowing for more accurate simulation of human organ functions. In the field of drug testing, Mimetas has developed a unique three-dimensional organ-on-chip that has proved effective in maintaining cell viability for extended periods. |
Microfluidics Integration |
TissUse, Synlogic |
TissUse's microfluidic systems are designed for high-throughput applications and to allow the integration of several organ systems. SynLogic's platform combines microfluidics with synthetic biology, thereby increasing the functionality of organ-on-chip models. |
Data Analytics and AI Integration |
Insilico Medicine, AstraZeneca |
AI is being used to analyze the results of experiments on organs-on-a-chip, to improve the prediction of drug responses. AstraZeneca has teamed up with several technology companies to enhance its organ-on-a-chip platforms with advanced data analysis. |
Regulatory Compliance and Standardization |
Organovo, Hurel Corporation |
Regulators are actively working with the company to develop standards for organ-on-chip technology, to ensure that the technology is fit for clinical applications. Hurel has developed a series of standardised operating procedures for its organ-on-chip systems, which makes it easier for the technology to be used in research. |
Customization and Scalability |
CureMetrix, Acelity |
CureMetrix offers a flexible organ-on-a-chip solution to suit your needs. Acelity has developed a scalable manufacturing process for its organ-on-a-chip products, enabling wider distribution and use in clinical trials. |
Conclusion: Navigating the Organ-On-a-Chip Landscape
- The organ-on-a-chip market is highly competitive and largely fragmented. The market is dominated by both established players and new entrants. The market is dominated by North America and Europe, where regulatory and funding support for advanced biotechnologies are strong. Competition is fierce, and to gain a competitive edge, vendors need to strategically position themselves through capabilities in artificial intelligence, automation, and sustainable production. The established players are focusing on enhancing their technology offerings and forming strategic alliances, while the new entrants are disrupting the market with their agile solutions and innovative approaches. Strategic leaders need to focus on building capabilities in these key areas to remain agile and stay ahead of the curve in this fast-changing market.
Report Attribute/Metric |
Details |
Base Year For Estimation |
2021聽聽Forecast Period聽聽2023-2032聽聽Historical Data2019聽聽Forecast Units聽聽Value (USD Million)聽聽Report Coverage聽聽Revenue Forecast, Competitive Landscape, Growth Factors, and Trends聽聽Segments Covered聽聽Organ Type, Application and End-User聽聽Geographies Covered聽聽North America, Europe, Asia-Pacific, and Rest of the World (RoW)聽聽Key Vendors聽聽CN Bio Innovations Limited (UK), Emulate, Inc. (US), TissUse GmbH (Germany), MIMETAS BV (Netherlands), H碌rel Corporation, Nortis, Inc. (US), InSphero (Switzerland), TARA Biosystems, Inc. (US), Axosim (US), Organovo Holdings Inc. (US), BioIVT (US), HemoShear Therapeutics, LLC (US)聽聽Key Market Opportunities聽聽Ability of OOC models to reduce drug development costs drastically and grants by government and non-government entities聽聽Key Market Drivers路聽 Increasing investment by major companies in organ-on-a-chip research & development路聽 The growing demand for drug screening with organs-on-a-chips |
Historical Data |
2019 Forecast Units Value (USD Million) Report Coverage Revenue Forecast, Competitive Landscape, Growth Factors, and Trends Segments Covered Organ Type, Application and End-User Geographies Covered North America, Europe, Asia-Pacific, and Rest of the World (RoW) Key Vendors CN Bio Innovations Limited (UK), Emulate, Inc. (US), TissUse GmbH (Germany), MIMETAS BV (Netherlands), H碌rel Corporation, Nortis, Inc. (US), InSphero (Switzerland), TARA Biosystems, Inc. (US), Axosim (US), Organovo Holdings Inc. (US), BioIVT (US), HemoShear Therapeutics, LLC (US) Key Market Opportunities Ability of OOC models to reduce drug development costs drastically and grants by government and non-government entities Key Market Drivers路 Increasing investment by major companies in organ-on-a-chip research & development路 The growing demand for drug screening with organs-on-a-chips |
Forecast Period |
聽聽2023-2032聽聽Historical Data2019聽聽Forecast Units聽聽Value (USD Million)聽聽Report Coverage聽聽Revenue Forecast, Competitive Landscape, Growth Factors, and Trends聽聽Segments Covered聽聽Organ Type, Application and End-User聽聽Geographies Covered聽聽North America, Europe, Asia-Pacific, and Rest of the World (RoW)聽聽Key Vendors聽聽CN Bio Innovations Limited (UK), Emulate, Inc. (US), TissUse GmbH (Germany), MIMETAS BV (Netherlands), H碌rel Corporation, Nortis, Inc. (US), InSphero (Switzerland), TARA Biosystems, Inc. (US), Axosim (US), Organovo Holdings Inc. (US), BioIVT (US), HemoShear Therapeutics, LLC (US)聽聽Key Market Opportunities聽聽Ability of OOC models to reduce drug development costs drastically and grants by government and non-government entities聽聽Key Market Drivers路聽 Increasing investment by major companies in organ-on-a-chip research & development路聽 The growing demand for drug screening with organs-on-a-chips |
Growth Rate |
聽聽11.7% 2032聽聽Base Year2021聽聽Forecast Period聽聽2023-2032聽聽Historical Data2019聽聽Forecast Units聽聽Value (USD Million聽聽Report Coverage聽聽Revenue Forecast, Competitive Landscape, Growth Factors, and Trends聽聽Segments Covered聽聽Organ Type, Application and End-User聽聽Geographies Covered聽聽North America, Europe, Asia-Pacific, and Rest of the World (RoW)聽聽Key Vendors聽聽CN Bio Innovations Limited (UK), Emulate, Inc. (US), TissUse GmbH (Germany), MIMETAS BV (Netherlands), H碌rel Corporation, Nortis, Inc. (US), InSphero (Switzerland), TARA Biosystems, Inc. (US), Axosim (US), Organovo Holdings Inc. (US), BioIVT (US), HemoShear Therapeutics, LLC (US)聽聽Key Market Opportunities聽聽Ability of OOC models to reduce drug development costs drastically and grants by government and non-government entities聽聽Key Market Drivers路聽 Increasing investment by major companies in organ-on-a-chip research & development路聽 The growing demand for drug screening with organs-on-a-chips |