Acute Agitation Aggression Treatment Market Size

ID: MRFR/Pharma/7365-CR

128 Pages

Kinjoll Dey

October 2023

Acute Agitation and Aggression Treatment Market Research Report Information by Drug Class (First-Generation Anti-Psychotics, Second-Generation Anti-Psychotics, Benzodiazepines, and Others), by Route of Administration (Oral, Intramuscular, and Others), by Indication (Schizophrenia, Dementia, Bipolar Disorder, Depression, Drug-induced Agitation and Aggression, Alcohol Withdrawal, and Others), by End User (Hospitals & Clinics, Psychiatric Care Facilities, and Others), and Region (North America, Europe, Asia-Pacific, and Rest of the World)—F... read more

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Acute Agitation Aggression Treatment Size

Acute Agitation Aggression Treatment Market Growth Projections and Opportunities

Acute agitation aggression treatment Market size is estimated to reach USD 9.4 billion by 2032 at 6.95% CAGR during the forecast period. The Acute Agitation Aggression Treatment Market operates within a dynamic framework influenced by various factors that collectively shape its growth and development. Instantaneous agitation and violence are among the majority of symptoms of some mental illness. For that purpose, health personnel have to hurry up as well as to choose the well-functioning method of intervention. Overall, the goal is to ensure not only safety of the patients with psychosis but also health care providers and the surroundings. The market dimension is profoundly influenced by aspects like the ecrinence of mental health conditions, the progress of treatments techniques, the interplay of regulations, the changing psychiate care design, and the increasing need for safer and more patient-friendly approaches.

Advanced field in psychiatric care management brings the natural change to the industry of agitation and aggression medicines commercialization. Today, the patients are progressively finding the individuality and the psychocentric treatment in psychiatry. The range of agitation and aggression treatments integration that is now available makes comprehensive models that involve multidisciplinary teams work better together and also use holistic strategies. An interaction between psychiatrists, other health workers, and patients determines the dynamics of the market, which points out that exact treatment of emergencies calls for a more sophisticated approach to mental health.

The tendency towards favoring more secure and more patients' oriented procedures is a force that generally acts upon the market mechanism of acute agitation and aggression treatment market. The number of harmful symptoms which accompany the use of traditional anesthetics, like excessive sedation and respiratory depression, discovered the need of producing safer and well-tolerated alternatives. Healthcare providers and patients alike seek interventions that not only effectively manage acute agitation and aggression but also minimize the risks and discomfort associated with treatment. The emphasis on patient-centric care contributes to the evolving market dynamics.

Acute Agitation Aggression Treatment Market Size Graph

Market Highlights

Author

Kinjoll Dey

Research Analyst Level I

He is an extremely curious individual currently working in Healthcare and Medical Devices Domain. Kinjoll is comfortably versed in data centric research backed by healthcare educational background. He leverages extensive data mining and analytics tools such as Primary and Secondary Research, Statistical Analysis, Machine Learning, Data Modelling. His key role also involves Technical Sales Support, Client Interaction and Project management within the Healthcare team. Lastly, he showcases extensive affinity towards learning new skills and remain fascinated in implementing them.

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FAQs

What is the projected growth of the Acute Agitation and Aggression Treatment market?

The Acute Agitation and Aggression Treatment market is the expected increase in total market value of 13.04 USD billion over a defined forecast period 2025–2035. It is driven by factors such as demand trends, technological advances, regulatory changes, and geographic expansion.

What is the size of the Acute Agitation and Aggression Treatment market?

Acute Agitation and Aggression Treatment market size was valued at approximately 6.22 billion USD in 2024. This figure will reach 13.04 billion USD covering all regions (America, Europe, Asia, MEA and ROW), focusing its segments / services / distribution channels till 2035.

What is the CAGR of the Acute Agitation and Aggression Treatment market?

Acute Agitation and Aggression Treatment market is expected to grow at a CAGR of 6.95% between 2025 and 2035.

How much will the Acute Agitation and Aggression Treatment market be worth by 2035?

Acute Agitation and Aggression Treatment market is expected to be worth of 13.04 billion USD, reflecting growth driven by usage, technology and global demands by the end of 2035.

How will the Acute Agitation and Aggression Treatment market perform over the next 10 years?

Over the next 10 years the Acute Agitation and Aggression Treatment market is expected to shift from usd billion 6.22 to 13.04 billion USD, led by adoption of advanced tech, demographic trends, regulatory approvals, with potential headwinds from 2025 to 2035.

How much is the acute agitation and aggression treatment market?

How big is the US acute agitation and aggression treatment market?

The US is expected to hold a 70-80% share of the North American market for the acute agitation and aggression treatment market during the forecast period of 2024-2035.

1. Market Overview

2. Market Trends

3. Market Segment Insights

4. Key Players and Competitive Insights

5. Industry Developments

6. Market Segmentation

7. Report Scope

8. Market Highlights

9. FAQs

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Market Summary

As per MRFR analysis, the Acute Agitation Aggression Treatment Market was estimated at 6.22 USD Billion in 2024. The Acute Agitation Aggression Treatment industry is projected to grow from 6.66 USD Billion in 2025 to 13.04 USD Billion by 2035, exhibiting a compound annual growth rate (CAGR) of 6.95 during the forecast period 2025 - 2035.

Key Market Trends & Highlights

The Acute Agitation Aggression Treatment Market is experiencing a transformative shift towards personalized and technology-driven solutions.

The market is witnessing an increased focus on personalized treatment strategies tailored to individual patient needs.
Integration of technology in treatment modalities is becoming more prevalent, enhancing patient engagement and outcomes.
Multidisciplinary approaches are gaining traction, reflecting a holistic view of managing acute agitation and aggression.
Rising incidence of mental health disorders and advancements in pharmacological treatments are driving market growth, particularly in North America and the Asia-Pacific region.

Acute Agitation Aggression Treatment Market

CAGR

6.95%

Market Size & Forecast

2024 Market Size	6.22 (USD Billion)
2035 Market Size	13.04 (USD Billion)
CAGR (2025 - 2035)	6.95%
Largest Regional Market Share in 2024	North America

Major Players

Johnson & Johnson (US), Pfizer (US), Bristol-Myers Squibb (US), Eli Lilly and Company (US), AstraZeneca (GB), Roche (CH), Novartis (CH), Otsuka Pharmaceutical (JP), H. Lundbeck A/S (DK)

Market Trends

The Acute Agitation Aggression Treatment Market is currently experiencing a notable evolution, driven by an increasing recognition of the need for effective management strategies for individuals exhibiting acute agitation and aggression. This market encompasses a range of therapeutic interventions, including pharmacological treatments, behavioral therapies, and innovative approaches aimed at addressing the underlying causes of these behaviors. As mental health awareness continues to rise, stakeholders are increasingly focused on developing comprehensive treatment protocols that not only mitigate symptoms but also enhance overall patient well-being. Furthermore, the integration of technology in treatment modalities appears to be gaining traction, suggesting a shift towards more personalized and accessible care options. In addition, the Acute Agitation Aggression Treatment Market is likely to witness a growing emphasis on research and development initiatives. This trend may lead to the introduction of novel therapeutic agents and methodologies that could redefine treatment paradigms. Collaboration among healthcare providers, researchers, and pharmaceutical companies seems essential in fostering innovation and ensuring that emerging treatments are both effective and safe. As the landscape of mental health care continues to evolve, the Acute Agitation Aggression Treatment Market is poised for significant advancements that could ultimately improve outcomes for individuals facing these challenging conditions.

Increased Focus on Personalized Treatment

There is a growing trend towards personalized treatment approaches in the Acute Agitation Aggression Treatment Market. This shift emphasizes tailoring interventions to meet the unique needs of individuals, taking into account their specific circumstances and underlying conditions. Such strategies may enhance treatment efficacy and patient satisfaction.

Integration of Technology in Treatment

The incorporation of technology into treatment protocols is becoming increasingly prevalent. Telehealth services, mobile applications, and digital monitoring tools are being utilized to provide real-time support and enhance patient engagement. This trend suggests a move towards more accessible and flexible treatment options.

Emphasis on Multidisciplinary Approaches

A notable trend within the Acute Agitation Aggression Treatment Market is the emphasis on multidisciplinary approaches. Collaboration among various healthcare professionals, including psychiatrists, psychologists, and social workers, is seen as essential for developing comprehensive treatment plans that address the complex nature of agitation and aggression.

Acute Agitation Aggression Treatment Market Market Drivers

Rising Prevalence of Mental Health Disorders

The increasing incidence of mental health disorders globally is a primary driver of the Global Acute Agitation and Aggression Treatment Market Industry. Conditions such as schizophrenia, bipolar disorder, and severe depression contribute significantly to acute agitation and aggression. According to the World Health Organization, mental health disorders affect approximately 1 in 4 individuals at some point in their lives. This growing prevalence necessitates effective treatment options, thereby expanding the market. As awareness of mental health issues rises, the demand for innovative treatment solutions is likely to increase, further propelling market growth.

Market Segment Insights

By Treatment Type: Pharmacological Treatment (Largest) vs. Psychological Intervention (Fastest-Growing)

In the Acute Agitation Aggression Treatment Market, the treatment segment is composed of various approaches, each holding distinct market shares. Pharmacological Treatment remains the largest segment, offering a range of antipsychotic and sedative medications widely utilized in clinical settings. Meanwhile, Psychological Interventions, which include therapeutic techniques such as cognitive behavioral therapy, are gaining traction, attributed to their effectiveness in managing aggression and agitation without the need for medication. As awareness of mental health treatment options grows, both segments are prominent in the market landscape.

Pharmacological Treatment: (Dominant) vs. Psychological Intervention (Emerging)

Pharmacological Treatment is currently the dominant approach in managing acute agitation and aggression, primarily due to its quick efficacy in symptom control. This segment includes various medications that provide immediate relief and are preferred in emergency settings. In contrast, Psychological Interventions have emerged as a crucial component of treatment, focusing on holistic and long-term management of aggressive behaviors. This shift reflects a growing acknowledgment of the importance of mental health strategies, particularly in enhancing patient outcomes and reducing reliance on medication. The integration of both methods signifies an evolving treatment paradigm within the market, catering to diverse patient needs while emphasizing safety and therapeutic efficacy.

By Patient Demographics: Age Group (Largest) vs. Severity of Condition (Fastest-Growing)

In the Acute Agitation Aggression Treatment Market, the age group segment holds a significant share, with middle-aged adults accounting for the largest proportion of patients requiring treatment. This demographic is predominantly affected by various conditions leading to acute agitation and aggression episodes. The distribution also shows a substantial presence of the elderly population, who require specialized care due to age-related factors, thus impacting the overall market dynamics pertaining to age-related treatment options. The severity of condition also plays a crucial role, showing the fastest growth in the market as an increasing number of patients present with severe agitation and aggression symptoms. This trend can be attributed to heightened awareness among healthcare providers and patients, leading to increased diagnosis rates. Moreover, the growth is driven by advancements in treatment options and emerging therapies that specifically address severe cases of agitation and aggression, opening new avenues for market expansion.

Age Group: Middle-Aged Adults (Dominant) vs. Severity of Condition: Severe Cases (Emerging)

Within the Acute Agitation Aggression Treatment Market, middle-aged adults emerge as the dominant demographic, as they frequently present with disorders such as schizophrenia, bipolar disorder, and major depressive disorders that are associated with symptoms of acute agitation. This age group often receives focused treatment approaches, making it a stable segment for healthcare providers. In contrast, severe cases of agitation are considered an emerging trend, as healthcare systems are now adapting to better strategies for management and intervention. This growth is indicative of a broader understanding of the complexities surrounding severe behavioral symptoms and the need for tailored treatment, thus driving innovations and enhancing care frameworks for this subset of patients.

By Healthcare Setting: Inpatient Facility (Largest) vs. Emergency Department (Fastest-Growing)

In the Acute Agitation Aggression Treatment Market, the distribution among healthcare settings reveals that the Inpatient Facility segment accounts for the largest market share. This is primarily due to the comprehensive care and immediate intervention facilities that these institutions provide. Inpatient Facilities are equipped with the necessary resources and trained personnel to manage acute cases effectively, which fosters a stable patient environment and a structured treatment approach. Conversely, the Emergency Department is emerging rapidly as the fastest-growing segment. This growth is driven by an increasing number of patients presenting acute agitation issues, emphasizing the need for prompt treatment within emergency settings. Factors such as rising awareness of mental health challenges and the urgency of handling aggressive behavior contribute significantly to this surge in demand for services in emergency environments.

Inpatient Facility (Dominant) vs. Outpatient Clinic (Emerging)

The Inpatient Facility segment stands as the dominant force in the Acute Agitation Aggression Treatment Market. Its characteristics include a robust infrastructure designed for critical care, access to multi-disciplinary teams, and rigorous treatment protocols that enhance patient safety. Additionally, Inpatient Facilities benefit from comprehensive management resources, including pharmaceuticals and behavioral therapies tailored to patients with severe cases. On the other hand, the Outpatient Clinic segment is emerging as a formidable alternative, particularly for less severe cases. These clinics offer more accessible, cost-effective treatment options and cater to patients requiring ongoing management without hospitalization. The shift towards outpatient care reflects broader healthcare trends emphasizing patient convenience and resource optimization.

By Administration Route: Intravenous (Largest) vs. Intramuscular (Fastest-Growing)

The Acute Agitation Aggression Treatment Market features a variety of administration routes, with intravenous (IV) methods holding the largest market share. IV administration is favored in acute settings due to its rapid onset of action, ensuring timely relief from severe agitation and aggression. Oral and subcutaneous routes, while significant, lag behind in terms of immediate effect and patient compliance during crises, impacting their overall market share. The prevailing trend illustrates a preference for IV solutions in emergency departments, leading to its dominant position within this segment. In terms of growth trends, the intravenous segment benefits from increased awareness and advocacy for swift intervention protocols. Furthermore, the rising incidence of acute agitation in various patient populations propels demand for quick-acting treatments. The intramuscular route is emerging as a rapidly growing alternative, attracting attention for its balance between speed and ease of administration, particularly in non-hospital settings, thus capturing significant growth opportunities alongside the established IV segment.

Intravenous (Dominant) vs. Intramuscular (Emerging)

The intravenous (IV) administration route is characterized by its rapid delivery of medications directly into the bloodstream, providing immediate therapeutic effects critical in managing acute agitation and aggression. This route is prevalent in emergency departments, where speed is essential. Additionally, IV administration allows for precise control of dosage, which is vital in treating varying intensity levels of aggression. Conversely, the intramuscular (IM) route is gaining traction as an emerging option due to its simplicity and effectiveness in scenarios where IV access may be challenging. IM administration offers a quicker onset than oral routes while being less invasive than IV methods, thus appealing to both healthcare providers and patients in situations that require effective yet manageable interventions.

By Duration of Treatment: Short-term (Largest) vs. Long-term (Fastest-Growing)

The Acute Agitation Aggression Treatment Market is primarily segmented into short-term, long-term, crisis intervention, and maintenance therapy. Among these segments, short-term treatment is recognized as the largest, catering particularly to acute episodes of agitation where immediate intervention is crucial. Conversely, long-term treatment is rapidly gaining traction, supported by increasing awareness and the need for ongoing management of chronic agitation issues. As healthcare systems evolve, these differentiations in treatment duration are gaining more attention.

Short-term (Dominant) vs. Long-term (Emerging)

Short-term treatment methods serve as the dominant approach in the Acute Agitation Aggression Treatment Market due to their effectiveness in managing immediate crises. These treatments focus on rapid stabilization, often employing pharmacological interventions. In contrast, long-term approaches are emerging as essential for sustained mental health management, integrating therapeutic practices and community support. The shift towards long-term solutions is influenced by the significant benefits of ongoing care, reducing relapse rates and promoting overall well-being. As a result, healthcare providers are increasingly adopting long-term strategies to complement immediate care, leading to a more holistic treatment landscape.

Get more detailed insights about Acute Agitation and Aggression Treatment Market Research Report - Global Forecast till 2035

Regional Insights

North America : Market Leader in Treatment

North America is poised to maintain its leadership in the Acute Agitation Aggression Treatment Market, holding a significant market share of 3.11 in 2024. The region's growth is driven by increasing incidences of mental health disorders, heightened awareness of treatment options, and supportive regulatory frameworks. The demand for innovative therapies and medications is further fueled by ongoing research and development initiatives, which are critical in addressing acute agitation effectively. The competitive landscape in North America is robust, featuring key players such as Johnson & Johnson, Pfizer, and Eli Lilly. These companies are at the forefront of developing advanced treatment solutions, leveraging their extensive resources and expertise. The U.S. remains the leading country, supported by a well-established healthcare infrastructure and a high prevalence of mental health issues, ensuring a steady demand for effective treatment options.

Europe : Emerging Market Dynamics

Europe is witnessing a growing demand for Acute Agitation Aggression Treatment, with a market size of 1.85. Factors such as increasing mental health awareness, government initiatives to improve mental health services, and the rising prevalence of psychiatric disorders are driving this growth. Regulatory bodies are also emphasizing the need for effective treatment protocols, which is expected to enhance market dynamics significantly in the coming years. Leading countries in Europe include Germany, France, and the UK, where major pharmaceutical companies like AstraZeneca and Roche are actively involved in the market. The competitive landscape is characterized by a mix of established players and emerging biotech firms, all striving to innovate and provide effective solutions for acute agitation. The region's regulatory environment is becoming increasingly favorable, promoting the development of new therapies.

Asia-Pacific : Rapidly Growing Market Potential

The Asia-Pacific region, with a market size of 1.1, is rapidly emerging as a significant player in the Acute Agitation Aggression Treatment Market. The growth is driven by increasing awareness of mental health issues, rising disposable incomes, and expanding healthcare access. Governments are also implementing policies to enhance mental health services, which is expected to further stimulate demand for effective treatment options in the region. Countries like Japan, Australia, and China are leading the charge, with a growing presence of key players such as Otsuka Pharmaceutical and H. Lundbeck A/S. The competitive landscape is evolving, with both multinational corporations and local firms striving to capture market share. The region's diverse population and varying healthcare needs present unique opportunities for tailored treatment solutions, making it a focal point for future growth.

Middle East and Africa : Emerging Market Challenges

The Middle East and Africa region, with a market size of 0.16, faces unique challenges in the Acute Agitation Aggression Treatment Market. Despite these challenges, there is a growing recognition of the importance of mental health, leading to increased demand for treatment options. Factors such as rising awareness, government initiatives, and international collaborations are driving the market forward, albeit at a slower pace compared to other regions. Countries like South Africa and the UAE are making strides in improving mental health services, with local and international players working to enhance treatment accessibility. The competitive landscape is characterized by a mix of established pharmaceutical companies and emerging local firms. However, regulatory hurdles and limited resources remain significant challenges that need to be addressed to fully realize the market's potential.

Key Players and Competitive Insights

The Acute Agitation Aggression Treatment Market is characterized by a dynamic competitive landscape, driven by increasing incidences of mental health disorders and a growing recognition of the need for effective treatment options. Key players such as Johnson & Johnson (US), Pfizer (US), and Eli Lilly and Company (US) are at the forefront, each adopting distinct strategies to enhance their market presence. Johnson & Johnson (US) focuses on innovation through the development of novel therapeutic agents, while Pfizer (US) emphasizes strategic partnerships to expand its product portfolio. Eli Lilly and Company (US) is investing heavily in digital transformation to improve patient engagement and treatment adherence, collectively shaping a competitive environment that prioritizes innovation and patient-centric solutions.

The market structure appears moderately fragmented, with several players vying for market share. Key business tactics include localizing manufacturing to reduce costs and optimize supply chains, which is particularly relevant in the context of global economic fluctuations. The collective influence of these major companies suggests a competitive landscape where agility and responsiveness to market demands are crucial for success.

In November 2025, Johnson & Johnson (US) announced a collaboration with a leading telehealth provider to enhance access to its acute agitation treatment solutions. This strategic move is likely to broaden the reach of its products, particularly in underserved regions, thereby increasing patient access and potentially driving revenue growth. The partnership underscores the importance of integrating technology into treatment delivery, aligning with current trends in healthcare.

In October 2025, Pfizer (US) launched a new clinical trial aimed at evaluating the efficacy of its latest drug formulation for acute agitation. This initiative not only demonstrates Pfizer's commitment to research and development but also positions the company to capture a larger share of the market by potentially offering a more effective treatment option. The trial's outcomes could significantly influence prescribing practices and patient outcomes, thereby enhancing Pfizer's competitive edge.

In September 2025, Eli Lilly and Company (US) unveiled a digital platform designed to support healthcare providers in managing patients with acute agitation. This platform integrates AI-driven analytics to personalize treatment plans, reflecting a broader trend towards digitalization in healthcare. By leveraging technology, Eli Lilly aims to improve treatment adherence and patient outcomes, which may set a new standard in the market.

As of December 2025, current competitive trends indicate a strong shift towards digitalization, sustainability, and AI integration within the Acute Agitation Aggression Treatment Market. Strategic alliances are increasingly shaping the landscape, enabling companies to pool resources and expertise. Looking ahead, competitive differentiation is likely to evolve from traditional price-based competition to a focus on innovation, technology, and supply chain reliability, as companies strive to meet the growing demand for effective and accessible treatment options.

Key Companies in the Acute Agitation Aggression Treatment Market market include

Industry Developments

In July 2022, Impel Pharmaceuticals commenced a Phase 2a proof-of-concept study for INP105, a nasal formulation of olanzapine, aimed at addressing acute agitation in individuals diagnosed with autism spectrum disorder (ASD). This investigation utilizes Impel's unique Precision Olfactory Delivery (POD) technology, designed to administer drugs to the upper nasal cavity, providing a non-invasive approach with a swift onset of action.

Otsuka Pharmaceutical Co., Ltd. has established itself as a significant contributor in the market for treating acute agitation and aggression. In June 2022, the company, in partnership with H. Lundbeck A/S, reported favorable outcomes from a Phase III clinical trial of brexpiprazole aimed at addressing agitation in individuals with Alzheimer's dementia.

In December 2024, Axsome Therapeutics revealed its intention to pursue marketing approval for its oral medication, AXS-05, aimed at addressing agitation in individuals diagnosed with Alzheimer's disease. The medication showed considerable delays in relapse time and provided symptom relief in the majority of the four late-stage studies carried out.

Future Outlook

Acute Agitation Aggression Treatment Market Future Outlook

The Acute Agitation Aggression Treatment Market is projected to grow at a 6.95% CAGR from 2024 to 2035, driven by increasing prevalence of mental health disorders and advancements in treatment methodologies.

New opportunities lie in:

Development of telehealth platforms for remote patient monitoring
Integration of AI-driven analytics for personalized treatment plans
Expansion of training programs for healthcare professionals in de-escalation techniques

By 2035, the market is expected to achieve substantial growth, reflecting evolving treatment paradigms and increased demand.

Market Segmentation

Acute Agitation Aggression Treatment Market Treatment Type Outlook

Pharmacological Treatment
Psychological Intervention
Physical Restraint
Environmental Modification

Acute Agitation Aggression Treatment Market Healthcare Setting Outlook

Emergency Department
Inpatient Facility
Outpatient Clinic
Home Care

Acute Agitation Aggression Treatment Market Administration Route Outlook

Oral
Intravenous
Intramuscular
Subcutaneous

Acute Agitation Aggression Treatment Market Patient Demographics Outlook

Age Group
Gender
Severity of Condition
Co-morbidities

Acute Agitation Aggression Treatment Market Duration of Treatment Outlook

Short-term
Long-term
Crisis Intervention
Maintenance Therapy

Report Scope

MARKET SIZE 2024	6.22(USD Billion)
MARKET SIZE 2025	6.66(USD Billion)
MARKET SIZE 2035	13.04(USD Billion)
COMPOUND ANNUAL GROWTH RATE (CAGR)	6.95% (2024 - 2035)
REPORT COVERAGE	Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
BASE YEAR	2024
Market Forecast Period	2025 - 2035
Historical Data	2019 - 2024
Market Forecast Units	USD Billion
Key Companies Profiled	Johnson & Johnson (US), Pfizer (US), Bristol-Myers Squibb (US), Eli Lilly and Company (US), AstraZeneca (GB), Roche (CH), Novartis (CH), Otsuka Pharmaceutical (JP), H. Lundbeck A/S (DK)
Segments Covered	Treatment Type, Patient Demographics, Healthcare Setting, Administration Route, Duration of Treatment
Key Market Opportunities	Integration of digital therapeutics and telehealth solutions in the Acute Agitation Aggression Treatment Market.
Key Market Dynamics	Rising demand for innovative therapies drives competition and regulatory scrutiny in the Acute Agitation Aggression Treatment Market.
Countries Covered	North America, Europe, APAC, South America, MEA