Postoperative Pain Management Market Size

ID: MRFR/Pharma/0738-HCR

200 Pages

Rahul Gotadki

October 2025

Postoperative Pain Management Market Research Report By Product Type (Analgesics, Local Anesthetics, Opioids, Nonsteroidal Anti-Inflammatory Drugs, Adjuvants), By Administration Route (Oral, Intravenous, Transdermal, Regional, Subcutaneous), By Application (Orthopedic Surgery, Cardiothoracic Surgery, General Surgery, Gynecological Surgery, Urological Surgery), By End User (Hospitals, Ambulatory Surgical Centers, Home Care Settings) and By Regional (North America, Europe, South America, Asia Pacific, Middle East and Africa) - Industry Forecas... read more

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Post Operative Pain Management Size

Post-Operative Pain Management Market Growth Projections and Opportunities

Post-Operative Pain Management Market will reach USD 62.63 billion by 2032 at 4.9% CAGR. Post-Operative Pain Management Market dynamics are shaped by several variables. The global rise in surgery is a factor. The number of procedures rises as the world population ages. Effective post-operative pain treatment is needed due to the rise in surgical procedures, from simple to complicated.

Medical technological advances also shape the market. Post-operative treatment has been transformed by less invasive procedures and customized medication delivery devices. These technology advances increase pain management, recuperation time, and patient outcomes. Thus, healthcare providers and institutions are embracing these cutting-edge technologies, driving the post-operative pain management market.

The regulatory environment also affects market dynamics. Market companies' strategy and product development are influenced by strict pain management medication and device approval and commercialization requirements. Market players must follow regulations to assure product safety and efficacy. Post-operative pain care enterprises may face legislative changes that affect their market position and competitive advantage.

Economic issues also shape markets. Economic growth, healthcare spending, and reimbursement regulations affect post-operative pain treatment availability and cost. Insurance coverage, government backing, and consumer spending on healthcare affect market demand. Economic volatility and healthcare budget limits might hinder market growth, but good economic conditions can boost the post-operative pain treatment industry.

Increasing awareness and emphasis on patient-centric treatment also affect market dynamics. Patients are becoming more aware and proactive about their healthcare, requiring individualized and effective pain management. This shift in patient expectations is driving market companies to create patient-centric goods and services, creating a competitive and dynamic environment.

Another important element affecting post-operative pain treatment is demographics. Effective pain treatment is needed because the aging population, especially in industrialized nations, is increasingly prone to chronic illnesses and surgery. Urbanization and lifestyle changes increase surgical procedures, further affecting the market.

Post-Operative Pain Management Market Size Graph

Market Highlights

Author

Rahul Gotadki

Assistant Manager

He holds an experience of about 7+ years in Market Research and Business Consulting, working under the spectrum of Life Sciences and Healthcare domains. Rahul conceptualizes and implements a scalable business strategy and provides strategic leadership to the clients. His expertise lies in market estimation, competitive intelligence, pipeline analysis, customer assessment, etc. In addition to the above, his other responsibility includes strategic tracking of high growth markets & advising clients on the potential areas of focus they could direct their business initiatives

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FAQs

What is the projected growth of the Post-Operative Pain Management market?

The Pain Management after surgery market is the expected increase in total market value of 72.62 USD billion over a defined forecast period 2025–2035. It is driven by factors such as demand trends, technological advances, regulatory changes, and geographic expansion.

What is the size of the Post-Operative Pain Management market?

Pain Management after surgery market size was valued at approximately 42.82 billion USD in 2024. This figure will reach 72.62 billion USD covering all regions (America, Europe, Asia, MEA and ROW), focusing its segments / services / distribution channels till 2035.

What is the CAGR of the Post-Operative Pain Management market?

Post-Operative Pain Management market is expected to grow at a CAGR of 4.92% between 2025 and 2035.

How much will the Post-Operative Pain Management market be worth by 2035?

Pain Management after surgery market is expected to be worth of 72.62 billion USD, reflecting growth driven by usage, technology and global demands by the end of 2035.

How will the Post-Operative Pain Management market perform over the next 10 years?

Over the next 10 years the Post-Operative Pain Management market is expected to shift from usd billion 42.82 to 72.62 billion USD, led by adoption of advanced tech, demographic trends, regulatory approvals, with potential headwinds from 2025 to 2035.

What was the projected market size of the Global Postoperative Pain Management Market in 2024?

The Global Postoperative Pain Management Market was valued at 35.94 USD Billion in 2024.

What will be the expected market size of the Global Postoperative Pain Management Market in 2035?

The Pain Management after surgery market is expected to grow and reach a valuation of 52.7 USD Billion by 2035.

Which region is expected to dominate the Global Postoperative Pain Management Market by 2024?

North America is expected to dominate the market with a valuation of 15.5 USD Billion in 2024.

How large was the European market for postoperative pain management in 2024?

The European market for postoperative pain management is anticipated to be valued at 9.2 USD Billion in 2024.

What are the projected values for Opioids in the Global Postoperative Pain Management Market by 2035?

Opioids are expected to be valued at 14.0 USD Billion in the market by 2035.

1. Market Overview

2. Market Trends

3. Market Segment Insights

4. Key Players and Competitive Insights

5. Industry Developments

6. Market Segmentation

7. Report Scope

8. Market Highlights

9. FAQs

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Market Summary

As per Market Research Future analysis, the Post-Operative Pain Management Market Size was estimated at 42.82 USD Billion in 2024. The Post-Operative Pain Management industry is projected to grow from 44.92 USD Billion in 2025 to 72.62 USD Billion by 2035, exhibiting a compound annual growth rate (CAGR) of 4.92 during the forecast period 2025 - 2035.

Key Market Trends & Highlights

The Post-Operative Pain Management Market is evolving towards innovative and patient-centric solutions.

Multimodal analgesia is gaining traction as a preferred approach to enhance pain relief post-surgery. Digital health integration is becoming increasingly prevalent, facilitating remote monitoring and personalized pain management. The focus on non-opioid alternatives is intensifying, driven by the need to mitigate opioid-related risks. Rising surgical procedures and technological advancements in pain management are key drivers propelling market growth in North America and Asia-Pacific.

Post-Operative Pain Management Market

CAGR

4.92%

Market Size & Forecast

2024 Market Size	42.82 (USD Billion)
2035 Market Size	72.62 (USD Billion)
CAGR (2025 - 2035)	4.92%
Largest Regional Market Share in 2024	North America

Major Players

Johnson & Johnson (US), <a href="https://www.pfizer.com/news/press-release/press-release-detail/pfizer_reports_results_from_three_phase_4_studies_demonstrating_embeda_morphine_sulfate_and_naltrexone_hydrochloride_extended_release_capsules_cii_impact_on_drug_liking_and_withdrawal_symptoms">Pfizer</a> (US), Boehringer Ingelheim (DE), AbbVie (US), Novartis (CH), Mylan (US), AstraZeneca (GB), Teva Pharmaceutical Industries (IL), GSK (GB)

Market Trends

The Post-Operative Pain Management Market is currently experiencing a notable evolution, driven by advancements in medical technology and a growing emphasis on patient-centered care. Healthcare providers are increasingly recognizing the importance of effective pain management strategies to enhance recovery outcomes and improve overall patient satisfaction. This shift is reflected in the rising adoption of multimodal analgesia approaches, which combine various pharmacological and non-pharmacological interventions to address pain more comprehensively. Furthermore, the integration of digital health solutions, such as telemedicine and mobile health applications, is facilitating better monitoring and management of post-operative pain, allowing for more personalized treatment plans. In addition, there is a discernible trend towards the development of novel analgesics and non-opioid alternatives, as the medical community seeks to mitigate the risks associated with opioid use. This focus on innovation is likely to reshape the landscape of pain management, as new therapies emerge that offer effective relief with fewer side effects. As the Post-Operative Pain Management Market continues to evolve, stakeholders must remain vigilant in adapting to these changes, ensuring that they meet the diverse needs of patients while adhering to regulatory standards and best practices.

Multimodal Analgesia

The Post-Operative Pain Management Market is witnessing a shift towards multimodal analgesia, which employs a combination of medications and techniques to manage pain more effectively. This approach not only enhances pain relief but also reduces the reliance on opioids, addressing concerns related to addiction and side effects.

Digital Health Integration

The integration of digital health technologies is transforming the Post-Operative Pain Management Market. Telehealth services and mobile applications are enabling healthcare providers to monitor patients remotely, facilitating timely interventions and personalized pain management strategies.

Focus on Non-Opioid Alternatives

There is an increasing emphasis on developing non-opioid analgesics within the Post-Operative Pain Management Market. This trend reflects a broader commitment to finding safer pain relief options that minimize the risks associated with opioid prescriptions, thereby improving patient safety.

Post-Operative Pain Management Market Market Drivers

Market Growth Projections

The Global Postoperative Pain Management Market Industry is projected to experience substantial growth over the coming years. The market is expected to reach 35.9 USD Billion in 2024 and is forecasted to grow to 52.7 USD Billion by 2035, reflecting a compound annual growth rate of 3.54% from 2025 to 2035. This growth is driven by various factors, including the increasing number of surgical procedures, advancements in pain management technologies, and heightened awareness of the importance of effective pain control. As the market evolves, stakeholders are likely to explore new opportunities to enhance patient care and optimize pain management strategies.

Rising Surgical Procedures

The increasing number of surgical procedures globally drives the Global Postoperative Pain Management Market Industry. As healthcare systems evolve and improve, more patients undergo surgeries, leading to a heightened demand for effective pain management solutions. For instance, the World Health Organization indicates that surgical procedures are expected to rise significantly, with millions of surgeries performed annually. This trend necessitates advanced pain management strategies to enhance patient recovery and satisfaction. Consequently, the market is projected to grow from 35.9 USD Billion in 2024 to 52.7 USD Billion by 2035, reflecting a compound annual growth rate of 3.54% from 2025 to 2035.

Increase in Chronic Pain Conditions

The rising prevalence of chronic pain conditions globally is a significant driver of the Global Postoperative Pain Management Market Industry. Patients with chronic pain often require surgical interventions, leading to an increased demand for effective postoperative pain management solutions. According to the National Institutes of Health, millions of individuals suffer from chronic pain, necessitating comprehensive pain management strategies. This growing patient population underscores the need for innovative pain management solutions, contributing to the market's expansion as healthcare providers seek to address the unique challenges associated with managing pain in these patients.

Growing Awareness of Pain Management

There is a notable increase in awareness regarding the importance of effective pain management in postoperative care, which significantly influences the Global Postoperative Pain Management Market Industry. Healthcare providers, patients, and policymakers are increasingly recognizing that adequate pain control is essential for recovery and overall patient satisfaction. Educational initiatives and guidelines from health organizations emphasize the need for comprehensive pain management strategies. This growing awareness is likely to drive demand for various pain management solutions, contributing to the market's expansion as healthcare systems prioritize patient-centered care.

Advancements in Pain Management Technologies

Technological advancements in pain management are reshaping the Global Postoperative Pain Management Market Industry. Innovations such as patient-controlled analgesia devices, regional anesthesia techniques, and non-opioid analgesics provide healthcare professionals with more effective tools to manage postoperative pain. These advancements not only improve patient outcomes but also reduce the reliance on opioids, addressing the growing concerns regarding opioid misuse. As hospitals and clinics adopt these technologies, the market is likely to experience substantial growth, aligning with the increasing emphasis on personalized medicine and enhanced recovery protocols.

Regulatory Support for Pain Management Practices

Regulatory bodies worldwide are increasingly supporting the development and implementation of effective pain management practices, which positively impacts the Global Postoperative Pain Management Market Industry. Initiatives aimed at improving pain management protocols and reducing opioid prescriptions are being introduced. For example, guidelines from the Centers for Disease Control and Prevention encourage the use of multimodal analgesia approaches. This regulatory support fosters innovation and encourages healthcare providers to adopt evidence-based practices, ultimately enhancing patient care and satisfaction while driving market growth.

Market Segment Insights

By Application: Surgical Procedures (Largest) vs. Chronic Pain Management (Fastest-Growing)

In the Post-Operative Pain Management Market, the application segment shows diverse value distribution. Surgical Procedures continue to hold the largest market share, driven primarily by the increasing number of surgical interventions globally. This segment's established demand is augmented by ongoing technological advancements and refined surgical techniques that contribute to enhanced pain management protocols. Conversely, Chronic Pain Management is emerging as a significant segment, reflecting changing patient demographics and growing awareness regarding the importance of effectively managing long-term pain conditions. The trend towards personalized pain management and the utilization of multimodal approaches drive the growth of Chronic Pain Management, making it the fastest-growing segment. Key factors such as the rising incidence of chronic illnesses and a broader acceptance of <a href="https://www.marketresearchfuture.com/reports/pain-management-market-5975">pain management</a> therapies contribute to this upward trajectory. Additionally, healthcare systems are increasingly prioritizing pain management, which cultivates a supportive environment for innovative therapies to flourish within this category.

Post-Operative Pain Management: Surgical Procedures (Dominant) vs. Chronic Pain Management (Emerging)

In the realm of Post-Operative Pain Management, Surgical Procedures stand out as the dominant force, characterized by a well-established framework within healthcare settings. This segment benefits from extensive clinical guidelines and best practices, ensuring effective pain relief post-surgery. Increasing surgical volumes and a focus on improving patient recovery experiences bolster this segment's robust position. On the other hand, Chronic Pain Management is quickly gaining traction as an emerging segment. It primarily focuses on long-term pain management strategies, incorporating newer treatment methodologies such as physical therapy and psychological support. This segment reflects a shift towards a more holistic approach to pain management, with tailored solutions that address individual patient needs, which, in turn, enhances its market relevance.

By Type of Pain Relief: Pharmacological (Largest) vs. Interventional (Fastest-Growing)

The post-operative pain management market showcases a diverse range of pain relief types, with pharmacological strategies leading in market share. This includes opioids, non-steroidal anti-inflammatory drugs (NSAIDs), and anesthetics, which are widely utilized for their effectiveness in pain reduction. Other notable approaches such as interventional techniques, which encompass nerve blocks and catheter placements, are garnering increasing attention as they provide longer-lasting relief with fewer systemic effects compared to traditional pharmacological methods. Growth trends in the pain relief segment indicate a shift towards more patient-centered approaches, with interventional methods emerging as the fastest-growing category. Factors driving this growth include advancements in technology, increasing awareness of the side effects of opioid medications, and a push towards multi-modal pain management strategies. Additionally, the rising demand for non-invasive techniques is reshaping how pain management after surgery is managed, emphasizing the importance of tailored treatment plans to enhance patient recovery experiences.

Pharmacological (Dominant) vs. Interventional (Emerging)

Pharmacological pain relief methods stand as the dominant force in the post-operative pain management market, primarily due to their widespread acceptance and established efficacy. These include a variety of analgesics such as opioids and NSAIDs, which are considered standard in managing acute pain post-surgery. However, interventional pain relief methods are emerging rapidly, characterized by techniques like nerve blocks and epidural analgesia. These approaches are favored for their ability to offer targeted pain relief while minimizing systemic side effects associated with oral medications. The shift towards interventional methods reflects a growing emphasis on holistic pain management, where reducing reliance on opioids is crucial to addressing the ongoing crisis. The combination of both pharmacological and interventional methods ultimately aims to enhance patient outcomes and satisfaction.

By Patient Demographics: Age Group (Largest) vs. Gender (Fastest-Growing)

In the Post-Operative Pain Management Market, the distribution of market share among patient demographics reveals that the Age Group is the largest segment, capturing a significant portion due to the higher incidence of surgeries among older patients. Conversely, Gender has emerged as a rapidly growing segment, with an increasing recognition of the differing pain management after surgery needs and responses between males and females, thereby garnering more attention from healthcare providers.

Age Group (Dominant) vs. Gender (Emerging)

The Age Group serves as the dominant segment in the Post-Operative Pain Management Market, primarily influenced by the aging population that requires more surgical interventions. Older patients often experience varying requirements for pain management due to differences in comorbidities, medication tolerance, and psychological factors associated with aging. On the other hand, the Gender segment is emerging, recognizing the importance of gender-specific approaches to pain management. Research indicates that women may report higher pain levels and different pain experiences than men, driving the need for tailored protocols and treatments in pain management practices.

Get more detailed insights about Post-operative Pain Management Market Research Report - Forecast to 2035

Regional Insights

North America : Market Leader in Pain Management

North America is poised to maintain its leadership in the Post-Operative Pain Management Market, holding a significant market share of 21.5% as of 2024. The region's growth is driven by increasing surgical procedures, a rising aging population, and advancements in pain management technologies. Regulatory support and favorable reimbursement policies further catalyze market expansion, ensuring that innovative pain relief solutions are accessible to patients. The competitive landscape in North America is robust, featuring key players such as Johnson & Johnson, Pfizer, and AbbVie. These companies are at the forefront of developing advanced analgesics and non-opioid pain management solutions. The U.S. remains the largest market, supported by extensive healthcare infrastructure and a focus on improving patient outcomes. As the demand for effective pain management continues to rise, North America is expected to lead the market well into the future.

Europe : Emerging Market with Growth Potential

Europe's Post-Operative Pain Management Market is valued at €10.5 billion, reflecting a growing demand for effective pain relief solutions. The region benefits from stringent regulatory frameworks that promote the development and approval of innovative pain management therapies. Increasing awareness of post-surgical pain management and a rise in elective surgeries are key drivers of market growth, alongside a focus on patient-centered care and improved healthcare access. Leading countries in this region include Germany, France, and the UK, where major pharmaceutical companies like Boehringer Ingelheim and Novartis are actively involved. The competitive landscape is characterized by a mix of established players and emerging biotech firms, all striving to meet the evolving needs of healthcare providers and patients. As regulatory bodies continue to support innovation, Europe is set to enhance its position in the global market.

Asia-Pacific : Rapidly Growing Market Segment

The Asia-Pacific region is witnessing significant growth in the Post-Operative Pain Management Market, currently valued at $8.0 billion. Factors such as increasing surgical procedures, a growing population, and rising healthcare expenditures are driving demand for effective pain management solutions. Additionally, government initiatives aimed at improving healthcare infrastructure and access to pain relief therapies are expected to further boost market growth in the coming years. Countries like China, India, and Japan are leading the charge in this market, with a mix of local and international players, including Teva Pharmaceutical Industries and GSK. The competitive landscape is evolving, with a focus on developing affordable and effective pain management options tailored to the needs of diverse patient populations. As the region continues to invest in healthcare advancements, its market share is projected to expand significantly.

Middle East and Africa : Emerging Market with Challenges

The Middle East and Africa (MEA) region, with a market size of $2.82 billion, is gradually emerging in the Post-Operative Pain Management Market. The growth is driven by increasing surgical procedures and a rising awareness of pain management among healthcare providers. However, challenges such as regulatory hurdles and limited access to advanced pain management therapies hinder rapid market expansion. Governments are working to improve healthcare systems, which may enhance market conditions in the future. Leading countries in the MEA region include South Africa and the UAE, where local and international players are striving to establish a foothold. Companies like AstraZeneca are focusing on expanding their presence in this market. The competitive landscape is characterized by a mix of established pharmaceutical firms and new entrants, all aiming to address the unique challenges of pain management in diverse healthcare settings.

Key Players and Competitive Insights

The Post-Operative Pain Management Market is characterized by a dynamic competitive landscape, driven by the increasing demand for effective pain relief solutions and the growing emphasis on patient-centered care. Major players such as Johnson & Johnson (US), Pfizer (US), and AbbVie (US) are strategically positioned to leverage their extensive portfolios and innovative capabilities. Johnson & Johnson (US) focuses on advancing its surgical pain management solutions, while Pfizer (US) emphasizes the development of novel analgesics. AbbVie (US) is actively pursuing partnerships to enhance its product offerings, indicating a trend towards collaborative innovation that shapes the competitive environment.

In terms of business tactics, companies are increasingly localizing manufacturing and optimizing supply chains to enhance efficiency and responsiveness to market demands. The competitive structure of the market appears moderately fragmented, with key players exerting substantial influence through their established brands and distribution networks. This fragmentation allows for niche players to emerge, potentially disrupting traditional market dynamics.

In November 2025, Pfizer (US) announced the launch of a new pain management drug that utilizes a unique delivery system, which is expected to improve patient compliance and outcomes. This strategic move not only reinforces Pfizer's commitment to innovation but also positions the company to capture a larger market share in the post-operative segment. The introduction of this product may significantly alter the competitive landscape by setting new standards for efficacy and patient experience.

In October 2025, AbbVie (US) entered into a strategic partnership with a leading technology firm to integrate AI-driven analytics into its pain management solutions. This collaboration aims to enhance the precision of pain assessment and treatment personalization, reflecting a broader trend towards digital transformation in healthcare. By leveraging AI, AbbVie (US) is likely to improve patient outcomes and streamline its operational processes, thereby gaining a competitive edge.

In September 2025, Johnson & Johnson (US) expanded its global footprint by establishing a new manufacturing facility in Asia, aimed at increasing production capacity for its pain management products. This expansion not only demonstrates Johnson & Johnson's commitment to meeting rising demand but also highlights the importance of regional manufacturing capabilities in ensuring supply chain reliability. Such strategic investments are crucial for maintaining competitiveness in a rapidly evolving market.

As of December 2025, current trends in the Post-Operative Pain Management Market include a pronounced shift towards digitalization, sustainability, and the integration of AI technologies. Strategic alliances are increasingly shaping the landscape, enabling companies to pool resources and expertise for enhanced innovation. Looking ahead, competitive differentiation is likely to evolve from traditional price-based strategies to a focus on technological advancements, innovative solutions, and robust supply chain management. This shift underscores the necessity for companies to adapt and innovate continuously in order to thrive in an increasingly complex market.

Key Companies in the Post-Operative Pain Management Market market include

Industry Developments

The Global Postoperative Pain Management Market has seen notable developments, with increased focus on innovative pain management solutions. Zynerba Pharmaceuticals and AbbVie have made advancements in cannabis-derived therapies aimed at improving patient outcomes. In September 2023, Baxter International launched an enhanced version of its pain management system that integrates newer technology for more precise dosage.

Recently, Roche has been increasing its investment in pain research, emphasizing non-opioid alternatives to reduce dependency concerns. Additionally, Pacira Pharmaceuticals reported a significant increase in sales for its non-opioid pain relief product in Q2 of 2023, reflecting a growing preference among healthcare providers for safer pain management options. Merger and acquisition activity has also gained momentum, particularly with Johnson and Johnson exploring potential acquisitions to expand its analgesic portfolio in June 2023.

Furthermore, there has been a marked growth in the market valuation, influenced by rising surgical procedures and the ongoing opioid crisis, which has led to a surge in demand for effective and safer postoperative pain relief methods. Recent strides in research and collaboration among major players such as Boehringer Ingelheim and Mylan indicate a strong commitment to addressing unmet needs in postoperative care.

Future Outlook

Post-Operative Pain Management Market Future Outlook

The Post-Operative Pain Management Market is projected to grow at a 4.92% CAGR from 2024 to 2035, driven by technological advancements, increasing surgical procedures, and a focus on patient-centered care.

New opportunities lie in:

Development of personalized pain management solutions using AI analytics.
Expansion of telehealth services for post-operative follow-ups.
Integration of wearable pain management devices in clinical settings.

By 2035, the market is expected to be robust, reflecting advancements and increased demand for effective pain management solutions.

Market Segmentation

Post-Operative Pain Management Market Application Outlook

Surgical Procedures
Chronic Pain Management
Acute Pain Management
Palliative Care
Rehabilitation

Post-Operative Pain Management Market Type of Pain Relief Outlook

Pharmacological
Non-Pharmacological
Interventional
Physical Therapy
Psychological Support

Post-Operative Pain Management Market Patient Demographics Outlook

Age Group
Gender
Health Status
Surgical History
Pain Tolerance

Report Scope

MARKET SIZE 2024	42.82(USD Billion)
MARKET SIZE 2025	44.92(USD Billion)
MARKET SIZE 2035	72.62(USD Billion)
COMPOUND ANNUAL GROWTH RATE (CAGR)	4.92% (2024 - 2035)
REPORT COVERAGE	Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
BASE YEAR	2024
Market Forecast Period	2025 - 2035
Historical Data	2019 - 2024
Market Forecast Units	USD Billion
Key Companies Profiled	Johnson & Johnson (US), Pfizer (US), Boehringer Ingelheim (DE), AbbVie (US), Novartis (CH), Mylan (US), AstraZeneca (GB), Teva Pharmaceutical Industries (IL), GSK (GB)
Segments Covered	Application, Type of Pain Relief, Patient Demographics
Key Market Opportunities	Integration of digital therapeutics and personalized medicine in the Post-Operative Pain Management Market.
Key Market Dynamics	Rising demand for non-opioid analgesics drives innovation and regulatory scrutiny in post-operative pain management solutions.
Countries Covered	North America, Europe, APAC, South America, MEA