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The market dynamics of the Renal Disease market are centered around addressing the complexities of kidney-related disorders, emphasizing the need for comprehensive solutions and advancements in nephrology. Understanding the multifaceted factors influencing this dynamic healthcare sector is crucial for effective management and treatment of renal diseases.
A major market dynamic is the growing incidence of Chronic Kidney Diseases (CKD), which stands currently as one of the biggest threats. Factors like attaining age, better lifestyles, and increase in diabetes conditions all contributes to the crease in demand for kidney failure management and treatment.
Renal replacement therapy (RRT) being a major prospect in the market, further improvement in RRT modalities especially in dialysis technologies, strongly contributes to the market success. Innovations in the delivery and application of hemodialysis and peritoneal dialysis methods capture the market, leading to better patients results, which is the reason for both the growth and evolution of the market.
The market is influenced by kidney transplant innovations directly or indirectly. The recent improvements in organ preservation, long-term immunosuppressive medication regimens, and expanded living donor programs generally lean toward higher success rates leading the way in renal disease treatment care.
The best prevention and possibly the most prolific of them all is the emphasis on preventive care and early detection, a major factor predominantly in the market. Consequently, public health activities that led to prompt diagnosis of kidney diseases in the first place have been in the frontline leading to mere the existence of suppliers.
The evolution of the market is also dependent on new pharmaceutical developments in renal therapies. New medications for instance, glomerulonephritis and what we call the diabetic nephropathy have been in development. This therefore, leads to diverse treatment options and ultimately affects the competition landscape.
Government policies and market reforms in the area of health care often significant affect the dynamics of the market. Owing to policies on the organ donation, executing the renal treatments with reimbursement handed in, and the initiatives of improving access to healthcare goods also have influences on the renal disease market.
The global nature of organ transplantation requires collaborative efforts. International collaboration in organ donation initiatives, sharing best practices, and addressing barriers to transplantation contribute to a more cohesive global response in the renal disease market.
The focus on patient-centered care and improving the quality of life for individuals with renal diseases is a significant factor in market dynamics. Holistic approaches that address not only medical needs but also psychosocial aspects contribute to shaping the future of renal disease management.
Renal Disease Market Highlights:
Global Renal Disease Market Overview
Renal Disease Market Size was valued at USD 97.82 Billion in 2023. The Global Renal Disease industry is projected to grow from USD 103.79 Billion in 2024 to USD 166.68 Billion by 2032, exhibiting a compound annual growth rate (CAGR) of 8.10% during the forecast period (2024 - 2032).
The increasing cases of diabetes & hypertension and the rising prevalence of chronic kidney disease are the key market drivers boosting the growth of the renal disease market.
Source Secondary Research, Primary Research, MRFR Database and Analyst Review
In October 2023, Zydus Lifesciences Limited and Sun Pharmaceutical Industries Limited (Sun Pharma) inked a licensing deal to jointly commercialize a novel pharmaceutical. The purpose of this collaboration is to enhance the treatment of patients suffering from anemia resulting from renal illness. Desidustat, according to its developers, is the inaugural oral pharmaceutical in India specifically designed to treat anemia resulting from chronic kidney disease (CKD).
Zydus has granted a semi-exclusive comarketing license to Sun Pharma for the RYTSTAT brand in India, as per the conditions of the agreement. Zydus debuted the medicine Oxemia under its brand name in 2022, and the business intends to continue its sales. Zydus will receive upfront license payments and further compensation upon achieving specified milestones.
In October 2023, Novartis announced positive initial results from the ongoing pivotal Phase III ALIGN study of atrasentan, an oral endothelin A receptor antagonist (ERA), in patients with IgAN. The safety profile of atrasentan in the trial was consistent with the safety profile observed in the IgAN cohort of the Phase II AFFINITY investigation, which had been previously documented.
Novartis plans to file an application for accelerated approval in the US in 2024, using the results of this intermediate proteinuria endpoint trial. The notable reduction in proteinuria observed in this study's Phase III results demonstrates the potential of atrasentan to improve outcomes for individuals with IgAN. Their portfolio consists of three advanced therapeutics for IgAN, which have distinct characteristics. These therapies have the potential to offer valuable treatment choices for those suffering from this incapacitating condition. One of these medicines, iptacopan, has recently demonstrated good results in its Phase III trial.
Renal Disease Market Trends
- Increasing Cases of Diabetes and Hypertension to Boost the Market Growth
Diabetes, hypertension, and kidney failure are three conditions that are closely related and impact each other. The millions of minuscule filtering units within each kidney are damaged over time by excessive amounts of sugar in the blood, leading to kidney failure. According to a report by The International Diabetes Federation (IDF), in March 2020, 13.3% of the total population of the US approximately around 30,987,900 people are diabetic. IDF also predicts that by 2045, the North America and Caribbean (NAC) region will have 63 million diabetic people in the region.
Furthermore, hypertension also negatively impacts proper kidney functioning. Uncontrolled high blood pressure can narrow, weaken, or stiffen the arteries surrounding the kidneys over time. These arteries cannot carry enough oxygenated blood to the renal tissue due to their impairment causing kidney tissue damage. According to the National Kidney Foundation, uncontrolled high blood pressure is the second leading cause of kidney failure in the US.
In addition, according to the Centers for Disease Control and Prevention (CDC), hypertension is a primary cause of stroke, heart attack, and renal failure. Hypertension, obesity, diabetes, and heart failure were responsible for 64 % of Covid-19 hospitalizations during the pandemic. Obese people are also more likely to develop hypertension. Therefore, increasing diabetes and hypertension cases across the globe increases the demand for dialysis, anti-hypertensive & diabetes medication, and Kidney transplantation leading to the growth of the renal disease market.
Renal Disease Market Segment Insights
Renal Disease Disease Type Insights
The renal disease market segmentation, based on disease type, includes chronic kidney disease, and end-stage renal disease. The chronic kidney disease type segment held the majority share in 2022 in respect to the renal disease market revenue. Chronic Kidney Disease (CKD), also called chronic kidney failure, is characterized by loss of kidney function over time. The main risk factors for CKD are high blood pressure, diabetes, and heart disease. According to the National Kidney Foundation, the treatment of chronic kidney disease is likely to exceed USD 48 billion per year in the US.
Renal Disease Treatment Insights
The renal disease market segmentation, based on treatment, includes dialysis, medication, and kidney transplantation. The dialysis segment dominated the market in 2022 in respect to the renal disease market. Dialysis is the removal of waste products and excess fluid such as water, solutes, and toxins from the blood when the kidneys stop working properly. It is generally performed when 85-90% of kidney function is gone, GFR falls below 15, and kidneys no longer work well enough to sustain a patient’s body.
According to the 2023 Annual Data Report by the United States Renal Data System (USRDS), indicates that over 809,000 Americans are living with end-stage kidney disease (ESKD). Out of these, approximately 555,000 patients are undergoing dialysis treatment, while the remainder have received kidney transplants​. The dialysis segment involves antihypertensive drugs, erythropoiesis-stimulating agents (ESAs), potassium binders, and phosphate binders. Antihypertensive drugs are used to lower the high blood pressure of the patient.
Latest Industry Developments in Renal Disease Treatment Segment
June 2024: Abbott has launched a next-generation portable dialysis device, featuring advanced sensors and connectivity for real-time monitoring of treatment effectiveness, aiming to enhance patient adherence and outcomes in chronic kidney disease patients.
May 2024: Amgen has introduced a new oral medication, a phosphate binder, for managing hyperphosphatemia in dialysis patients, showing superior efficacy, safety, and fewer side effects compared to existing treatments.
July 2024: Novartis has released a novel immunosuppressant for kidney transplantation patients, reducing organ rejection risk and minimizing long-term effects, using a targeted mechanism of action.
Renal Disease End User Insights
The renal disease market segmentation, based on indication includes dialysis centers, hospital & clinics, and research and academic institutes. The dialysis centers held the largest market share in 2022 with respect to the renal disease market revenue. Dialysis centers provide dialysis for patients with chronic kidney failure. In dialysis centers, trained nurses and technicians perform the procedure on patients with renal diseases.
December 2020 GlaxoSmithKline plc (UK) received the US Food and Drug Administration (FDA) approval for BENLYSTA (belimumab) for the treatment of adult patients with active lupus nephritis (LN) who are receiving standard therapy
Figure 2 Renal Disease Market, by End User, 2022 & 2032 (USD Billion)
Source Secondary Research, Primary Research, MRFR Database and Analyst Review
Renal Disease Regional Insights
By region, the study segments the market into North America, Europe, Asia-Pacific, and the Rest of the World. North America Renal Disease held the largest market share in 2022. This is attributed to the rising prevalence of kidney disease, the growing prevalence of diabetes and hypertension, and the rapid growth in the geriatric population.
Further, the major countries studied are The U.S, Canada, Germany, France, UK, Italy, Spain, China, Japan, India, Australia, South Korea, and Brazil.
Figure 3 Renal Disease Market Share (%) By Region 2022
Source Secondary Research, Primary Research, MRFR Database and Analyst Review
Europe renal disease market accounts for the second-largest market share due to the increasing healthcare spending, various government initiatives & awareness campaigns regarding CKD, availability of technologically advanced products, and the presence of newly established state-of-the-art healthcare facilities in the region. Further, the Germany renal disease market held the largest market share, and the UK renal disease market was the fastest-growing market in the European region.
The Asia-Pacific renal disease market is expected to grow at a significant growth rate during the forecast period. This is due to the factors, such as growth in the aging population, various lifestyle stress, a large population base, improving quality of diagnosis, and growing patient affordability are factors expected to boost the market over the forecast period. Moreover, China renal disease market held the largest market share, and the India renal disease market was the fastest-growing market in the Asia-Pacific region. Hence, Asia-Pacific is anticipated to register the highest growth rate over the forecast period from 2024–2032.
Renal Disease Key Market Players & Competitive Insights
Major market players are spending a lot of money on R&D to increase their product lines, which will help the renal disease market grow even more. Market participants are also taking a range of strategic initiatives to grow their worldwide footprint, including new product launches, contractual agreements, mergers and acquisitions, increased investments, and collaboration with other organizations. Competitors in the renal disease industry must offer cost-effective items to expand and survive in an increasingly competitive and rising market environment.
One of the primary business strategies adopted by manufacturers in the renal disease industry to benefit clients and expand the renal disease market sector is to manufacture locally to reduce operating costs.
Akebia Therapeutics Inc. (US) is a trusted leader in the renal community delivering unique products to people suffering from kidney disease. Its product Vadadustat is a HIF-prolyl-hydroxylase (HIF-PH) inhibitor in Phase III development for the treatment of anemia of CKD. In addition to Vadadustat, the company is engaged in developing a HIF-based portfolio of product candidates that target serious diseases of unmet need. Keryx Biopharmaceuticals is a subsidiary of Akebia Therapeutics.
For instance, in June 2021, Akebia Therapeutics, Inc. collaborated with Otsuka Pharmaceutical Co., Ltd. (Japan) Ostuka company also announced the US Food and Drug Administration (FDA) accepted filing the New Drug Application (NDA) for vadadustat for the treatment of anemia due to chronic kidney disease (CKD) in both adult patients on dialysis and adult patients not on dialysis.
Key Companies in the Renal Disease Market Includes
- Abbott (US)
- Amgen Inc. (US)
- AstraZeneca (UK)
- Bristol-Myers Squibb Company (US)
- Hoffmann-La Roche Ltd. (Switzerland)
- Pfizer Inc. (US)
- GlaxoSmithKline PLC (UK)
- Keryx Biopharmaceuticals, Inc. (US)
- Kissei Pharmaceutical Co., Ltd. (Japan)
- Novartis (Switzerland)
Renal Disease Industry Developments
May 2021 Bristol Myers Squibb (US) declared that OPDIVO (nivolumab) 240 mg (injection for intravenous use) every two weeks or 480 mg every four weeks in combination with CABOMETYX (cabozantinib) 40 mg once daily tablets was approved by the US Food and Drug Administration (FDA) for the first-line treatment of patients with advanced renal cell carcinoma (RCC)
January 2021 Fresenius Medical Care (Germany) announced that the company's Frenova division has enrolled the first participants in Colombia as its new initiative to develop the largest renal-focused genomic registry in the world. The renal-focused genomic registry represents a new business line within Frenova, based in Fresenius Medical Care's Medical Office
June 2021 Novartis AG (Switzerland) announced positive new interim Phase II data showing investigational iptacopan (LNP023), a first-in-class, oral, targeted factor B inhibitor improved estimated glomerular filtration rate (eGFR) slope and stabilized kidney function in patients with C3 glomerulopathy (C3G) treated with iptacopan
Renal Disease Market Segmentation
Renal Disease Type Outlook
- Chronic Kidney Disease
- End-Stage Renal Disease
Renal Disease Treatment Outlook
- Dialysis
- Medication
- Kidney Transplantation
Renal Disease End User Outlook
- Dialysis Centers
- Hospital & Clinics
- Research and Academic Institutes
Renal Disease Regional Outlook
- North America
- US
- Canada
- Europe
- Germany
- France
- UK
- Italy
- Spain
- Rest of Europe
- Asia-Pacific
- China
- Japan
- India
- Australia
- South Korea
- Rest of Asia-Pacific
- Rest of the World
- Middle East
- Africa
- Latin America
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