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    Unnatural Amino Acids Market

    ID: MRFR/Pharma/3479-CR
    216 Pages
    Rahul Gotadki
    July 2020

    Unnatural Amino Acids Market Research Report Information By Type (D-Amino Acids & Derivatives, DL-Amino Acids & Derivatives, B-Amino Acids & Derivatives, Cyclic Amino Acids & Derivatives, L-Amino Acid Derivatives, Gamma-Amino Butyric Acid {GABA}, Gamma-Amino-Beta-Hydroxybutyric Acid (GABOB), Synthetic-Amino Acids, Others), By Application (Liver Diseases, Cancer, Inflammatory Disease, Genetic Diseases), By End-User (Pharmaceutical & Biotechnological, Companies, Research Laboratories) And By Region (North America, Europe, A...

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    Unnatural Amino Acids Market Summary

    As per Market Research Future Analysis, the Unnatural Amino Acids Market was valued at USD 2.11 billion in 2024 and is projected to grow to USD 6.73 billion by 2035, with a CAGR of 11.12% from 2025 to 2035. Key drivers include the rising demand for drug intermediates, advancements in diagnostics, and the expansion of protein-based therapeutics. The market is segmented by type, application, and end-user, with D-amino acids dominating the type segment and liver diseases leading in applications. North America holds the largest market share, driven by pharmaceutical and biotechnological companies.

    Key Market Trends & Highlights

    The Unnatural Amino Acids Market is witnessing significant growth due to various trends.

    • Growing applications in diagnostics and biosensors are enhancing market demand.
    • D-amino acids & derivatives dominate the market due to their versatile applications.
    • The liver diseases segment leads in application due to the rising prevalence of liver conditions.
    • North America is the largest regional market, driven by research laboratories and pharmaceutical companies.

    Market Size & Forecast

    2024 Market Size USD 2.11 Billion
    2035 Market Size USD 6.73 Billion
    CAGR 11.12%

    Major Players

    Key players include Abbott, AbbVie, Ajinomoto Co., Inc., AstraZeneca, BASF SE, and Pfizer.

    Unnatural Amino Acids Market Trends

    Growing applications in diagnostics and biosensors are driving the market growth.

    The growing applications in diagnostics and biosensors are driving the trend in the unnatural amino acids market. Unnatural amino acids, or non-canonical amino acids, are synthetic or modified amino acids that do not naturally occur in living organisms. These amino acids have unique properties and functionalities that make them valuable in various fields, including diagnostics and biosensors.In diagnostics, unnatural amino acids are used to develop novel diagnostic tools and techniques for detecting and monitoring diseases. They can be incorporated into diagnostic probes and sensors to enhance their sensitivity and specificity.

    Unnatural amino acids can also be used to design specific peptide sequences that bind to disease markers, enabling the development of highly accurate diagnostic assays.Unnatural amino acids play a crucial role in biosensors in developing biosensing platforms. They can be used as sensing elements or as part of the recognition elements in biosensors. 

    Their unique properties allow for the selective and sensitive detection of target analytes, such as biomarkers or environmental pollutants. Unnatural amino acids can be engineered to interact specifically with the target analyte, enabling the biosensor to provide rapid and accurate results.The growing applications in diagnostics and biosensors are driven by the increasing Demand for more efficient and reliable diagnostic tools and biosensing technologies. The need for early and accurate disease detection and the monitoring of various parameters in healthcare and environmental settings has fueled the Market CAGR of unnatural amino acids.

    Additionally, demand for novel drug candidates: Unnatural amino acids provide researchers with a broad range of possibilities to design and develop novel drug candidates with improved potency, selectivity, and pharmacokinetic properties. The pharmaceutical industry's need for innovative therapies drives the Demand for unnatural amino acids in drug discovery.Furthermore, Expansion of protein-based therapeutics: Protein-based therapeutics, including monoclonal antibodies, enzymes, and peptide drugs, are gaining prominence in the pharmaceutical market. Unnatural amino acids enable the development of engineered proteins with enhanced stability, activity, and specificity, driving their adoption in this field.

    Growing Demand for protein engineering: 

    Protein engineering has emerged as a powerful tool in drug discovery, enzymology, and industrial biotechnology. Unnatural amino acids play a crucial role in expanding the genetic code and introducing new functionalities into proteins, enabling the creation of novel enzymes, therapeutics, and biomaterials. Advancements in chemical synthesis and genetic engineering The development of efficient synthetic methodologies and genetic engineering tools has facilitated the production and incorporation of unnatural amino acids into proteins. These advancements have expanded the possibilities for protein design, drug discovery, and biotechnological applications. 3.

    Increasing investment in biopharmaceutical research: The biopharmaceutical industry invests heavily in research and development to discover new drugs and therapeutic modalities. Unnatural amino acids offer the potential to develop highly specific and effective drugs, leading to increased interest and investments in this field. Thus, driving the Unnatural Amino Acids market revenue.

    The increasing integration of unnatural amino acids in pharmaceuticals and biotechnology suggests a transformative shift in therapeutic applications and product development.

    U.S. National Institutes of Health

    Unnatural Amino Acids Market Drivers

    Rising Demand in Pharmaceuticals

    The Global Unnatural Amino Acids Market Industry is experiencing a surge in demand from the pharmaceutical sector. Unnatural amino acids are increasingly utilized in drug development, particularly in the creation of peptide-based therapeutics. For instance, the incorporation of these amino acids can enhance the efficacy and stability of drugs. As the global pharmaceutical market is projected to reach 2.1 USD Billion in 2024, the demand for unnatural amino acids is likely to grow in tandem, driven by the need for innovative treatments and personalized medicine.

    Market Segment Insights

    Unnatural Amino Acids MarketSegment Insights

    Unnatural Amino Acids Type Insights

     The Unnatural Amino Acids market segmentation, based on type, includes D-Amino Acids & Derivatives, DL-Amino Acids & Derivatives, B-Amino Acids & Derivatives, Cyclic Amino Acids & Derivatives L-Amino Acid Derivatives, Gamma-Amino Butyric Acid {GABA}, Gamma-Amino-Beta-Hydroxybutyric Acid (GABOB), Synthetic-Amino Acids, Others. The d-amino acids & derivatives segment dominates the market;due to the unique properties and versatile applications of D-amino acids in pharmaceuticals, biotechnology, and chemical industries. The increasing Demand for peptide-based therapeutics, enzyme inhibitors, and specialty chemicals drives the market growth, supported by advancements in synthetic biology and chemical synthesis techniques.

    Unnatural Amino Acids Application Insights

    Based on Application, the Unnatural Amino Acids market segmentation includes Liver Diseases, Cancer, Inflammatory Diseases, and Genetic Diseases. The liver diseases segment dominates the market; due to the increasing prevalence of liver diseases globally and the rising Demand for effective diagnostic tools and therapies. Unnatural amino acids play a vital role in liver disease diagnosis, treatment, and tissue engineering, driving their significance within this application segment. Ongoing research and development efforts advance knowledge and innovation in liver diseases and unnatural amino acids.

    Unnatural Amino Acids End-UserInsights

    The Unnatural Amino Acids market segmentation, based on End-User, includes Pharmaceutical & Biotechnological, Companies and Research Laboratories. The pharmaceutical & biotechnological segment dominates the market; due to the extensive applications of these amino acids in drug development, biotechnological products, diagnostics, and biosensors. Their ability to enhance the efficacy and specificity of pharmaceutical treatments, modify protein properties, and enable precise detection methods make them essential in the pharmaceutical and biotechnological industries. Ongoing research and development efforts further drive the significance of unnatural amino acids in these fields.

    Figure1: Unnatural Amino Acids Market, by End-User, 2022 & 2032 (USD billion) 

    Source: Secondary Research, Primary Research, Market Research Future Database, and Analyst Review

    Get more detailed insights about Unnatural Amino Acids Market Research Report - Forecast till 2032

    Regional Insights

    By Region, the study providesmarket insights into North America, Europe, Asia-Pacific, and Rest of the World. The North American Unnatural Amino Acids market will dominate this market due to the rising need for unnatural amino acids from research laboratories, academic institutes, and pharmaceutical and biotechnological companies.

    Further, the major countries studied in the market report are The U.S., Canada, German, France, the UK, Italy, Spain, China, Japan, India, Australia, South Korea, and Brazil.

    Figure2: Unnatural Amino Acids Market Share By Region 2022 (%)

    UNNATURAL AMINO ACIDS MARKET SHARE BY REGION

    Source: Secondary Research, Primary Research, Market Research Future Database, and Analyst Review

    Europe's Unnatural Amino Acids market accounts for the second-largest market share due to thedeveloping examination of food drug and feed expansion and agrochemicals and expanding interest in drug intermediates. Further, the German Unnatural Amino Acids market held the largest market share, and the UK Unnatural Amino Acids market was the fastest-growing market in the European Region.

    The Asia-Pacific Unnatural Amino Acids Market is expected to grow fastest from 2024 to 2032. This is due totechnological advancements, research and development activities, and regulatory policies. Moreover, China’s Unnatural Amino Acids market held the largest market share, and the Indian Unnatural Amino Acids market was the fastest-growing market in the Asia-Pacific region.

    Key Players and Competitive Insights

    Major Unnatural Amino Acids market companies are investing significantly in research and development activities to broaden their range of products. These strategic initiatives aim to fuel further growth in the market. Market participants are also undertaking various strategic activities to expand their footprint, with important market developments including new product launches, contractual agreements, mergers and acquisitions, higher investments, and collaboration with other organizations. To thrive in a highly competitive and growing market environment, the unnatural Amino Acids industry needs to provide cost-effective solutions. Companies in this industry must offer affordable products and provide value for money to their customers.

    Manufacturing locally to minimize operational costs is one of the key business tactics manufacturers use in the Unnatural Amino Acids industry to benefit clients and increase the market sector. In recent years, the Unnatural Amino Acids industry has offered some of the most significant medical advantages.

    Major players in the Unnatural Amino Acids market, including Abbott, AbbVie, Ajinomoto Co., Inc., Aminologics Co., AnaSpec Inc., AstraZeneca, BASF SE, Bayer, CU ChemieUetikon, Enzo-Life-Sciences Inc., GlaxoSmithKline Plc., Miat S.P.A., Novartis AG, Pfizer, Sigma-Aldrich Corporation., and To stimulate market demand, several companies in the unnatural Amino Acids industry are strategically investing in research and development initiatives. By focusing on R&D operations, these companies aim to enhance their product offerings, improve product quality, and explore new applications and uses for unnatural Amino Acids.

    Evotec SE is a publicly listed drug discovery and development company headquartered in Hamburg, Germany. The company operates globally through external alliances with pharmaceutical and biotechnology companies, academic institutions, patient advocacy groups, and venture capitalists. Evotec and Novo Nordisk partnered strategically to discover and develop small molecule therapies using Evotec's proprietary drug discovery platform. The collaboration aimed to leverage Evotec's expertise in medicinal chemistry and Novo Nordisk's knowledge in protein engineering to develop innovative therapies targeting metabolic diseases.

    Kyowa Kirin Co., Ltd. is a Japanese pharmaceutical and biotechnology company under Kirin Holdings and is among the 40 largest in the world by revenue. The company is headquartered in Chiyoda-ku, Tokyo, and is a Nikkei 225 stock index member.Kyowa Kirin and Ultragenyx Pharmaceutical announced a collaboration to develop and commercialize a novel enzyme replacement therapy for treating LAL-D (lysosomal acid lipase deficiency). The partnership aimed to combine Kyowa Kirin's expertise in protein engineering and Ultragenyx's capabilities in rare disease drug development to bring a new treatment option to patients with LAL-D.

    Key Companies in the Unnatural Amino Acids Market market include

    Industry Developments

    June 2021: Evotec and Novo Nordisk entered a strategic collaboration to discover and develop small molecule therapies using Evotec's proprietary drug discovery platform. The collaboration aimed to leverage Evotec's expertise in medicinal chemistry and Novo Nordisk's knowledge in protein engineering to develop innovative therapies targeting metabolic diseases.

    August 2021: Kyowa Kirin and Ultragenyx Pharmaceutical announced a collaboration to develop and commercialize a novel enzyme replacement therapy for treating LAL-D (lysosomal acid lipase deficiency). The partnership aimed to combine Kyowa Kirin's expertise in protein engineering and Ultragenyx's capabilities in rare disease drug development to bring a new treatment option to patients with LAL-D.

    Future Outlook

    Unnatural Amino Acids Market Future Outlook

    The Global Unnatural Amino Acids Market is projected to grow at a 11.12% CAGR from 2025 to 2035, driven by advancements in biotechnology, increasing demand in pharmaceuticals, and expanding applications in food and nutrition.

    New opportunities lie in:

    • Develop novel synthesis methods to enhance production efficiency and reduce costs.
    • Explore partnerships with pharmaceutical companies for tailored amino acid applications.
    • Invest in R&D for innovative formulations targeting the nutraceutical sector.

    By 2035, the market is expected to exhibit robust growth, positioning itself as a key player in biotechnology.

    Market Segmentation

    Unnatural Amino Acids Type Outlook

    • D-Amino Acids & Derivatives
    • DL-Amino Acids & Derivatives
    • B-Amino Acids & Derivatives
    • Cyclic Amino Acids & Derivatives L-Amino Acid Derivatives
    • Gamma-Amino Butyric Acid {GABA}
    • Gamma-Amino-Beta-Hydroxybutyric
    • Acid (GABOB)
    • Synthetic-Amino Acids
    • Others

    Unnatural Amino Acids End-User Outlook

    • Pharmaceutical & Biotechnological
    • Companies
    • Research Laboratories

    Unnatural Amino Acids Regional Outlook

    • US
    • Canada
    • Germany
    • France
    • UK
    • Italy
    • Spain
    • Rest of Europe
    Asia-Pacific
    • China
    • Japan
    • India
    • Australia
    • South Korea
    • Rest of Asia-Pacific
    Rest of the World
    • Middle East
    • Africa
    • Latin America

    Unnatural Amino Acids Application Outlook

    • Liver Diseases
    • Cancer
    • Inflammatory Disease
    • Genetic Diseases

    Report Scope

    Attribute/Metric Details
    Market Size 2024 USD 2.11 billion
    Market Size 2035 6.73 (Value (USD Billion))
    Compound Annual Growth Rate (CAGR) 11.12% (2025 - 2035)
    Base Year 2024
    Market Forecast Period 2025 - 2035
    Historical Data 2018- 2022
    Market Forecast Units Value (USD Billion)
    Report Coverage Revenue Forecast, Market Competitive Landscape, Growth Factors, and Trends
    Segments Covered Type, Application, End-User, and Region
    Geographies Covered North America, Europe, AsiaPacific, and the Rest of the World
    Countries Covered The U.S., Canada, German, France, UK, Italy, Spain, China, Japan, India, Australia, South Korea, and Brazil
    Key Companies Profiled  Abbott, AbbVie, Ajinomoto Co., Inc., Aminologics Co., AnaSpec Inc., AstraZeneca, BASF SE, Bayer, CU ChemieUetikon, Enzo-Life-Sciences Inc., GlaxoSmithKline Plc., Miat S.P.A., Novartis AG, Pfizer, Sigma-Aldrich Corporation
    Key Market Opportunities Progressively filling in research height for drugs, food and feed-added substances, agrochemicals, and other modern applications.
    Key Market Dynamics Developing examination on food, drug and feed expansion, and agrochemicals. Expanding interest in drug intermediates
    Market Size 2025 2.34 (Value (USD Billion))

    Market Highlights

    Author
    Rahul Gotadki
    Assistant Manager

    He holds an experience of about 7+ years in Market Research and Business Consulting, working under the spectrum of Life Sciences and Healthcare domains. Rahul conceptualizes and implements a scalable business strategy and provides strategic leadership to the clients. His expertise lies in market estimation, competitive intelligence, pipeline analysis, customer assessment, etc. In addition to the above, his other responsibility includes strategic tracking of high growth markets & advising clients on the potential areas of focus they could direct their business initiatives

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    FAQs

    How much is the Unnatural Amino Acids market?

    The Unnatural Amino Acids market size was valued at USD 1.9 Billion in 2023.

    What is the growth rate of the Unnatural Amino Acids market?

    The market is anticipated to grow at a CAGR of 11.1% during the forecast period, 2024-2032.

    Which Region witnessed the largest market share in the Unnatural Amino Acids market?

    North America had the largest share of the market

    Who are the major players in the Unnatural Amino Acids market?

    The major players in the market areAbbott, AbbVie, Ajinomoto Co., Inc., Aminologics Co., AnaSpec Inc., AstraZeneca, BASF SE, Bayer, CU ChemieUetikon, Enzo-Life-Sciences Inc., GlaxoSmithKline Plc., Miat S.P.A., Novartis AG, Pfizer, Sigma-Aldrich Corporation.

    Which type led the Unnatural Amino Acids market?

    The D-Amino Acids & Derivatives Unnatural Amino Acids category dominated the market in 2022.

    Which End-User witnessed the largest market share in the Unnatural Amino Acids market?

    Pharmaceutical & Biotechnologicalhad the largest share in the market.

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