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US ACE Inhibitors Market

ID: MRFR/HC/17733-HCR
100 Pages
Rahul Gotadki
October 2025

US ACE Inhibitors Market Research Report: By Drug (Lisinopril, Ramipril, Enalapril, Benazepril, Fosinopril, Captopril, Moexipril, Others), By Application (Heart Failure, Hypertension, Diabetes, Heart Attack, Chronic Kidney Disease, Others), By Dosage Form (Oral Tablets, Oral Solution) and By Distribution Channel (Retail Pharmacy, Hospital Pharmacy, E-commerce Websites, Online Drug Stores) - Forecast to 2035

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US ACE Inhibitors Market Summary

As per MRFR analysis, the US ace inhibitors market size was estimated at $1166.07 Million in 2024. The US ace inhibitors market is projected to grow from 1205.71 $ Million in 2025 to 1684.77 $ Million by 2035, exhibiting a compound annual growth rate (CAGR) of 3.4% during the forecast period 2025 - 2035.

Key Market Trends & Highlights

The US ace inhibitors market is experiencing robust growth driven by increasing healthcare needs and innovative treatments.

  • The market is witnessing a rising prevalence of cardiovascular diseases, which is driving demand for ace inhibitors.
  • Innovations in drug formulations are enhancing the efficacy and safety profiles of ace inhibitors, appealing to healthcare providers.
  • Regulatory support for new treatments is fostering a conducive environment for market expansion, particularly in the largest segment of hypertension management.
  • Key market drivers include the increasing aging population and rising healthcare expenditure, which are likely to sustain growth in the ace inhibitors market.

Market Size & Forecast

2024 Market Size 1166.07 (USD Million)
2035 Market Size 1684.77 (USD Million)

Major Players

Bristol-Myers Squibb (US), Novartis (CH), Sanofi (FR), Pfizer (US), Merck & Co. (US), AstraZeneca (GB), Teva Pharmaceutical Industries (IL), Lupin Pharmaceuticals (IN), Hikma Pharmaceuticals (GB)

US ACE Inhibitors Market Trends

The ACE Inhibitors Market is currently experiencing notable growth, driven by an increasing prevalence of hypertension and heart-related ailments among the population. This rise in chronic conditions has led to a heightened demand for effective therapeutic options, particularly those that target the renin-angiotensin system. Furthermore, advancements in pharmaceutical research and development are contributing to the introduction of novel formulations and delivery methods, enhancing patient compliance and treatment outcomes. As healthcare providers continue to prioritize evidence-based practices, the utilization of ace inhibitors is likely to expand, reflecting a shift towards more personalized medicine approaches. In addition, the regulatory landscape appears to be evolving, with agencies focusing on streamlining approval processes for new medications. This trend may facilitate quicker access to innovative treatments within the ace inhibitors market. Moreover, educational initiatives aimed at both healthcare professionals and patients are fostering greater awareness of the benefits associated with these medications. As a result, the market is poised for sustained growth, with potential opportunities for both established and emerging players to capitalize on the increasing demand for effective cardiovascular therapies.

Rising Prevalence of Cardiovascular Diseases

The incidence of cardiovascular diseases is on the rise, prompting a greater need for effective treatment options. This trend is likely to drive demand for ace inhibitors, as they are recognized for their efficacy in managing hypertension and heart failure.

Innovations in Drug Formulations

Recent advancements in drug formulations are enhancing the effectiveness and patient adherence to ace inhibitors. New delivery methods and combination therapies are emerging, which may improve therapeutic outcomes and broaden the market appeal.

Regulatory Support for New Treatments

Regulatory bodies are increasingly supportive of new treatments, streamlining approval processes for innovative medications. This trend may lead to a quicker introduction of novel ace inhibitors, potentially expanding treatment options for patients.

US ACE Inhibitors Market Drivers

Increasing Aging Population

The ace inhibitors market is experiencing growth due to the increasing aging population in the United States. As individuals age, the prevalence of hypertension and heart-related ailments rises, leading to a higher demand for effective treatments. According to the U.S. Census Bureau, by 2030, approximately 20% of the population will be 65 years or older. This demographic shift is likely to drive the need for medications such as ACE inhibitors, which are commonly prescribed for managing high blood pressure and heart failure. The aging population's health concerns are expected to significantly influence the ace inhibitors market, as healthcare providers seek to address the growing burden of cardiovascular diseases among older adults.

Advancements in Telemedicine

The rise of telemedicine in the United States is transforming the healthcare landscape, potentially benefiting the ace inhibitors market. Telehealth services have expanded access to healthcare, allowing patients to consult with healthcare providers remotely. This convenience may lead to increased diagnosis and treatment of hypertension and related conditions. According to a report from the American Medical Association, telehealth visits surged during recent years, and this trend appears to be continuing. As more patients engage with healthcare providers through telemedicine, the likelihood of receiving prescriptions for ACE inhibitors may increase, thereby driving market growth.

Rising Healthcare Expenditure

Healthcare expenditure in the United States continues to rise, which positively impacts the ace inhibitors market. The Centers for Medicare & Medicaid Services (CMS) projects that national health spending will reach nearly $6 trillion by 2027, accounting for approximately 19.7% of the GDP. This increase in spending allows for greater access to medications, including ACE inhibitors, as healthcare providers are more likely to prescribe these treatments to manage chronic conditions. Furthermore, the expansion of insurance coverage and the introduction of value-based care models may enhance patient access to necessary medications, thereby driving growth in the ace inhibitors market.

Focus on Preventive Healthcare

The shift towards preventive healthcare in the United States is influencing the ace inhibitors market. Healthcare systems are increasingly prioritizing preventive measures to reduce the incidence of chronic diseases, including hypertension. This focus encourages early diagnosis and treatment, which may lead to a higher utilization of ACE inhibitors as a preventive strategy. The U.S. Preventive Services Task Force recommends regular blood pressure screenings, which can facilitate timely interventions. As healthcare providers adopt preventive approaches, the demand for effective medications like ACE inhibitors is likely to grow, contributing to the overall expansion of the market.

Growing Awareness of Hypertension

There is a growing awareness of hypertension and its associated risks among the U.S. population, which is likely to bolster the ace inhibitors market. Public health campaigns and educational initiatives have increased knowledge about the importance of blood pressure management. The American Heart Association reports that nearly half of U.S. adults have hypertension, yet many remain undiagnosed or untreated. This awareness encourages individuals to seek medical advice and treatment, leading to higher prescriptions of ACE inhibitors. As healthcare providers emphasize the importance of managing hypertension, the demand for effective pharmacological interventions is expected to rise, positively influencing the ace inhibitors market.

Market Segment Insights

By Drug: Lisinopril (Largest) vs. Ramipril (Fastest-Growing)

In the US ace inhibitors market, Lisinopril holds a significant market share due to its wide acceptance and established efficacy among healthcare providers. Its strong presence is complemented by its cost-effectiveness, making it the preferred choice for many patients. Conversely, Ramipril is rapidly gaining traction, driven by its proven benefits in cardiovascular health and growing clinical endorsements, which contribute to its rising popularity in recent years. The growth trends within this segment are primarily influenced by the increasing prevalence of hypertension and cardiovascular diseases in the population. Furthermore, advancements in drug formulations and favorable treatment guidelines have enhanced the adoption rate of these ACE inhibitors. The strategic marketing efforts by pharmaceutical companies targeting both doctors and patients also play a crucial role in propelling the demand for both Lisinopril and Ramipril, contributing to their distinct positions within the market.

Lisinopril: Dominant vs. Ramipril: Emerging

Lisinopril, as the dominant segment of the US ace inhibitors market, is characterized by its extensive clinical usage and patient familiarity. It is recognized for its effectiveness in treating hypertension and heart failure, thus making it a staple in many medical practices. In contrast, Ramipril is emerging as a strong competitor, attributed to its progressive acceptance as a first-line treatment option for chronic conditions. Its unique mechanism of action and favorable safety profile make it increasingly preferred by healthcare professionals. The growth of Ramipril is fueled by ongoing clinical research that reinforces its benefits, and it is becoming the choice for more complex cases, allowing it to carve a niche in this competitive landscape.

By Application: Heart Failure (Largest) vs. Diabetes (Fastest-Growing)

In the US ace inhibitors market, the application segment reveals a significant distribution of market shares among various conditions. Heart Failure stands out as the largest segment, capturing a substantial share due to its prevalence and critical need for effective management solutions. Other notable segments include Hypertension and Chronic Kidney Disease, which also play vital roles in the therapeutic landscape. Conversely, Diabetes, while contributing a smaller portion to the overall market, is rapidly gaining ground and is expected to see increased focus from manufacturers looking to cater to this growing patient demographic. The growth trends for the application segment are largely driven by increasing awareness about chronic diseases and advancements in therapeutic technologies. As healthcare systems adopt more comprehensive treatment protocols, the demand for effective ace inhibitors for Heart Failure continues to escalate, making it a primary focus for pharmaceutical companies. Additionally, the rise in Diabetes cases in the population is positioning this segment as the fastest-growing, leading to innovative solutions aimed at improving patient outcomes. Overall, the landscape is evolving, driven by an aging population and an increased emphasis on chronic disease management.

Heart Failure (Dominant) vs. Diabetes (Emerging)

Heart Failure as a dominant application in the US ace inhibitors market is characterized by its high incidence rates and the necessity for ongoing treatment to manage the condition effectively. This segment benefits from a well-established therapeutic class, with numerous options available for healthcare providers, ensuring robust competition and innovation. In contrast, Diabetes is emerging as a significant area of growth, driven by rising prevalence rates and increased awareness of related complications. The focus on Diabetes is leading to enhanced research and development efforts concentrated on tailored therapies that address the specific needs of diabetic patients, creating opportunities for novel ace inhibitors to enter the market and fulfill unmet medical needs.

By Dosage Form: Oral Tablets (Largest) vs. Oral Solution (Fastest-Growing)

In the US ace inhibitors market, Oral Tablets dominate the Dosage Form segment, accounting for a significant market share compared to Oral Solutions. The prevalence of Oral Tablets is attributed to their convenience, ease of administration, and widespread acceptance among patients and healthcare providers. Conversely, Oral Solutions, while currently less prevalent, are gaining traction among specific patient populations, particularly those with difficulty swallowing tablets or requiring precise dosage adjustments. The growth trends within the Dosage Form segment are influenced by several factors. The increasing prevalence of hypertension and heart disease drives demand for user-friendly medication formats. Moreover, advancements in pharmaceutical formulations and the growing preference for personalized medicine are propelling the demand for Oral Solutions. This segment's dynamics will continue to evolve, with Oral Solutions expected to experience faster growth as healthcare providers recognize their therapeutic advantages.

Oral Tablets (Dominant) vs. Oral Solution (Emerging)

Oral Tablets are regarded as the dominant form in the Dosage Form segment of the US ace inhibitors market, favored for their stability and ease of use. They are ideal for long-term treatment plans and are often prescribed due to their efficient absorption and effective therapeutic outcomes. In contrast, Oral Solutions are emerging as a vital alternative, particularly beneficial for patients who have challenges with traditional tablets. They allow for flexible dosing and are particularly useful in pediatric and geriatric populations. Both forms are essential for an integrated approach to managing cardiovascular conditions, providing unique advantages tailored to patient needs.

By Distribution Channel: Retail Pharmacy (Largest) vs. E-commerce Websites (Fastest-Growing)

In the US ace inhibitors market, the distribution channels showcase a competitive landscape where Retail Pharmacy holds the largest share, catering to a broad base of consumers who prefer traditional purchasing methods. Hospital Pharmacy follows as a vital segment, providing critical access to medications for inpatient settings. Meanwhile, the rise of E-commerce Websites and Online Drug Stores reflects the changing consumer behavior, with more patients opting for the convenience of online shopping options despite their smaller current market share. Growth trends indicate that E-commerce Websites are becoming the fastest-growing segment, driven by increasing internet penetration and shifting consumer preferences towards online health solutions. The COVID-19 pandemic further accelerated this trend as healthcare providers and patients embraced digital channels. Additionally, growing investments in online pharmacy platforms and enhanced delivery options are expected to bolster this growth. Lifestyle changes and the emphasis on ease of access continue to influence these trends, positioning E-commerce Websites for considerable expansion in the coming years.

Retail Pharmacy (Dominant) vs. Online Drug Stores (Emerging)

Retail Pharmacy stands as the dominant force in the US ace inhibitors market, characterized by well-established relationships with patients and healthcare providers, along with the ability to offer immediate access to medications. The convenience of local accessibility and personalized service contributes significantly to its market strength. In contrast, Online Drug Stores, while emerging, are gaining ground through enhanced user experiences and competitive pricing strategies. They cater especially to technologically savvy consumers who prioritize convenience and anonymity in their purchasing decisions. Both segments have distinct advantages, with Retail Pharmacy relying on its physical presence and trust factor, whereas Online Drug Stores are revolutionizing the way consumers access medications with improved digital solutions and delivery efficiencies.

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Key Players and Competitive Insights

The ace inhibitors market is characterized by a competitive landscape that is increasingly shaped by innovation, strategic partnerships, and a focus on patient-centric solutions. Key players such as Bristol-Myers Squibb (US), Novartis (CH), and Pfizer (US) are actively engaged in enhancing their product portfolios and expanding their market reach. Bristol-Myers Squibb (US) emphasizes research and development, particularly in cardiovascular therapies, while Novartis (CH) focuses on digital health initiatives to improve patient outcomes. Pfizer (US) is leveraging its extensive distribution network to enhance accessibility, indicating a collective shift towards integrated healthcare solutions that prioritize patient needs.

The market structure appears moderately fragmented, with several players vying for market share through localized manufacturing and optimized supply chains. Companies are increasingly localizing their production to mitigate risks associated with global supply chain disruptions. This tactic not only enhances operational efficiency but also aligns with the growing demand for rapid response to market needs. The collective influence of these key players fosters a competitive environment where innovation and operational excellence are paramount.

In September 2025, Novartis (CH) announced a strategic partnership with a leading digital health company to develop an AI-driven platform aimed at improving patient adherence to ace inhibitor therapies. This move is significant as it reflects a broader trend towards integrating technology into treatment regimens, potentially enhancing patient outcomes and reducing healthcare costs. The partnership underscores Novartis's commitment to leveraging digital solutions to address challenges in medication adherence, which is critical in chronic disease management.

In October 2025, Pfizer (US) launched a new formulation of its ace inhibitor product, designed to improve bioavailability and patient compliance. This strategic introduction is noteworthy as it not only enhances the therapeutic profile of the medication but also positions Pfizer to capture a larger share of the market by addressing specific patient needs. The launch aligns with the company's broader strategy of innovation-driven growth, emphasizing the importance of product differentiation in a competitive landscape.

In August 2025, Merck & Co. (US) expanded its manufacturing capabilities in the US to increase production capacity for its ace inhibitors. This expansion is indicative of Merck's proactive approach to meet rising demand and ensure supply chain reliability. By enhancing its manufacturing footprint, Merck is likely to improve its responsiveness to market fluctuations, thereby strengthening its competitive position.

As of November 2025, the ace inhibitors market is witnessing trends that emphasize digitalization, sustainability, and the integration of AI technologies. Strategic alliances are increasingly shaping the competitive landscape, enabling companies to pool resources and expertise to drive innovation. The shift from price-based competition to a focus on technological advancement and supply chain reliability is evident. Moving forward, competitive differentiation will likely hinge on the ability to innovate and deliver value-added solutions that resonate with healthcare providers and patients alike.

Key Companies in the US ACE Inhibitors Market market include

Industry Developments

The US ACE Inhibitors Market has recently witnessed notable developments with major players like Bristol Myers Squibb, Novartis, and Merck actively involved in enhancing their product portfolios. In October 2023, Bristol Myers Squibb announced progress in clinical trials for novel ACE inhibitors aimed at treating hypertension and heart failure, reflecting the increasing focus on cardiovascular health. Additionally, Novartis is expanding its ACE inhibitor line by collaborating with Sandoz to introduce generic alternatives, thus aiming to make these critical medications more accessible.

AstraZeneca has also been making waves with its recent mHealth initiatives aimed at better patient adherence to ACE inhibitor therapies.

In terms of mergers and acquisitions, no major transactions specifically related to ACE inhibitors among the aforementioned companies have been reported recently in the last few months. The market valuation continues to grow as innovations and demand for effective treatments rise, with estimates suggesting a significant increase in revenue driven by the aging population and rising health care expenditures in the US. Over the past two years, key regulatory changes have facilitated market expansion, as governments promote cost-effective treatment options for chronic conditions, further stimulating the ACE inhibitors market trajectory.

Future Outlook

US ACE Inhibitors Market Future Outlook

The ace inhibitors market is projected to grow at a 3.4% CAGR from 2024 to 2035, driven by increasing hypertension prevalence and advancements in drug formulations.

New opportunities lie in:

  • Development of combination therapies to enhance efficacy and patient compliance.
  • Expansion into telehealth services for remote patient monitoring and prescription management.
  • Investment in AI-driven drug discovery to accelerate new product development.

By 2035, the ace inhibitors market is expected to solidify its position as a key player in cardiovascular therapeutics.

Market Segmentation

US ACE Inhibitors Market Drug Outlook

  • Lisinopril
  • Ramipril
  • Enalapril
  • Benazepril
  • Fosinopril
  • Captopril
  • Moexipril
  • others

US ACE Inhibitors Market Application Outlook

  • Heart Failure
  • Hypertension
  • Diabetes
  • Heart Attack
  • Chronic Kidney Disease
  • others

US ACE Inhibitors Market Dosage Form Outlook

  • Oral Tablets
  • Oral Solution

US ACE Inhibitors Market Distribution Channel Outlook

  • Retail Pharmacy
  • Hospital Pharmacy
  • E-commerce Websites
  • Online Drug Stores

Report Scope

MARKET SIZE 2024 1166.07(USD Million)
MARKET SIZE 2025 1205.71(USD Million)
MARKET SIZE 2035 1684.77(USD Million)
COMPOUND ANNUAL GROWTH RATE (CAGR) 3.4% (2024 - 2035)
REPORT COVERAGE Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
BASE YEAR 2024
Market Forecast Period 2025 - 2035
Historical Data 2019 - 2024
Market Forecast Units USD Million
Key Companies Profiled Bristol-Myers Squibb (US), Novartis (CH), Sanofi (FR), Pfizer (US), Merck & Co. (US), AstraZeneca (GB), Teva Pharmaceutical Industries (IL), Lupin Pharmaceuticals (IN), Hikma Pharmaceuticals (GB)
Segments Covered Drug, Application, Dosage Form, Distribution Channel
Key Market Opportunities Emerging therapies and personalized medicine are reshaping the ace inhibitors market landscape.
Key Market Dynamics Regulatory changes and technological advancements drive innovation and competition in the ace inhibitors market.
Countries Covered US

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FAQs

What is the projected market size of the US ACE Inhibitors Market in 2024?

The US ACE Inhibitors Market is expected to be valued at 1.55 billion USD in 2024.

What will the market value of the US ACE Inhibitors Market be by 2034?

By 2034, the US ACE Inhibitors Market is anticipated to reach a value of 2.17 billion USD.

What is the expected CAGR for the US ACE Inhibitors Market between 2025 and 2034?

The expected compound annual growth rate (CAGR) for the US ACE Inhibitors Market is 3.4% from 2025 to 2034.

Which application segment will be the largest in the US ACE Inhibitors Market in 2024?

In 2024, the largest application segment in the US ACE Inhibitors Market is Hypertension, valued at 0.8 billion USD.

How much is the Heart Failure application segment valued in 2024?

The Heart Failure application segment is valued at 0.35 billion USD in 2024.

What is the anticipated market value for Diabetic Nephropathy by 2034?

By 2034, the Diabetic Nephropathy application segment is expected to reach a value of 0.35 billion USD.

Who are the key players in the US ACE Inhibitors Market?

Key players in the US ACE Inhibitors Market include Sandoz, Bristol-Myers Squibb, Pfizer, and Merck, among others.

What is the market value for Myocardial Infarction in 2024?

In 2024, the Myocardial Infarction application segment is valued at 0.15 billion USD.

What are the growth drivers for the US ACE Inhibitors Market?

Growth drivers for the US ACE Inhibitors Market include the increasing prevalence of hypertension and cardiovascular diseases.

What trends are emerging in the US ACE Inhibitors Market?

Emerging trends include ongoing research in new drug formulations and increased focus on personalized medicine in treating hypertension and heart failure.

What is the current market size of the US ACE Inhibitors Market for the year 2024?

The US ACE Inhibitors Market is expected to be valued at 1.17 billion USD in 2024.

What is the projected market size of the US ACE Inhibitors Market by the year 2035?

By 2035, the US ACE Inhibitors Market is projected to reach a value of 1.69 billion USD.

What is the expected compound annual growth rate (CAGR) for the US ACE Inhibitors Market from 2025 to 2035?

The expected CAGR for the US ACE Inhibitors Market is 3.408 percent from 2025 to 2035.

Which drug segment dominates the US ACE Inhibitors Market?

Lisinopril is the dominant drug segment in the US ACE Inhibitors Market.

How much is the Lisinopril segment worth in the US ACE Inhibitors Market for the year 2024?

The Lisinopril segment is valued at 0.4 billion USD in 2024.

What will be the value of the Ramipril segment in the US ACE Inhibitors Market by 2035?

The Ramipril segment is expected to be valued at 0.43 billion USD by 2035.

What market value does the Enalapril segment hold in 2024?

The Enalapril segment holds a market value of 0.25 billion USD in 2024.

What challenges currently affect the US ACE Inhibitors Market?

Challenges include patent expiration and competition from generic drugs.

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