US RNA-Based Therapeutics Market Research Report By Technology (RNA Interference, Antisense Oligonucleotides, mRNA Therapeutics, CRISPR Technology), By Application (Oncology, Infectious Diseases, Genetic Disorders, Cardiovascular Diseases), By End Use (Pharmaceutical Companies, Research Institutions, Contract Research Organizations) and By Delivery Method (Liposomes, Nanoparticles, Viral Vectors, Electroporation) - Forecast to 2035

US RNA-Based Therapeutics Market Overview

As per MRFR analysis, the US RNA-Based Therapeutics Market Size was estimated at 1.62 (USD Billion) in 2023. The US RNA-Based Therapeutics Market Industry is expected to grow from 2 (USD Billion) in 2024 to 6.5 (USD Billion) by 2035. The US RNA-Based Therapeutics Market CAGR (growth rate) is expected to be around 11.31% during the forecast period (2025 - 2035).

Key US RNA-Based Therapeutics Market Trends Highlighted

The US RNA-Based Therapeutics Market is experiencing significant growth, driven by the increasing incidence of genetic disorders and the rising demand for more effective treatment options. One of the key drivers in this market is the advancement in RNA technology, particularly in messenger RNA (mRNA) therapeutics, which has gained immense popularity following the success of mRNA vaccines during the COVID-19 pandemic.

This technological evolution not only provides new avenues for personalized medicine but also enhances the development of targeted therapies for various diseases. Additionally, federal support through initiatives and funding from public health agencies is bolstering research and development activities in this sector, contributing to its rapid expansion.

There are considerable opportunities to be explored in the US RNA-Based Therapeutics Market, especially in the fields of cancer treatment and rare diseases. The ongoing research into RNA interference (RNAi) and antisense oligonucleotides presents promising avenues for innovation. Furthermore, collaborations between biotech firms and research institutions are likely to yield new therapeutics and delivery methods.

The evolving regulatory landscape in the US, along with accelerated approval pathways for RNA-based therapies, represents another opportunity that can be effectively captured by stakeholders in the market. Recently, the trend has shifted towards increasing investments in RNA-based platforms, as more companies seek to develop RNA therapeutics beyond vaccines.

Several pharmaceutical companies are now investing in manufacturing processes that enhance the scalability and efficiency of nucleotide production. The rise of patient-centric approaches and the focus on precision medicine further emphasize the need for continued innovation in RNA therapeutics. As the US market continues to adapt and grow, ongoing advancements are expected to mark a transformative period for RNA-based treatments, promoting better health outcomes across various patient populations.

Source: Primary Research, Secondary Research, MRFR Database and Analyst Review

US RNA-Based Therapeutics Market Drivers

Rising Prevalence of Genetic Disorders

The increasing prevalence of genetic disorders in the United States is a significant driver for growth in the US RNA-Based Therapeutics Market Industry. According to the National Institutes of Health (NIH), genetic disorders affect millions of Americans, with over 6,000 recognized disorders that can be attributed to genetic causes. This prevalent genetic landscape necessitates innovative treatments such as RNA-based therapies, which have shown promise in addressing these disorders at their root cause.

Leading organizations, including the American Society of Human Genetics, emphasize the need for more targeted therapies due to the escalating number of diagnosed genetic conditions, thereby fostering an environment conducive to advancements in the RNA-based therapeutics sector.

Advancements in Research and Development

The US RNA-Based Therapeutics Market Industry is poised for substantial growth owing to significant advancements in Research and Development (R&D) activities. The US government has prioritized funding for biotechnology, resulting in increased investments in RNA-related research. The National Science Foundation reported a consistent increase in funding for biomedical and biotechnology research, amounting to over USD 38 billion in recent fiscal years.

These investments fuel innovations in RNA-based therapeutics, enabling researchers and companies to develop more effective treatments. Established organizations such as Moderna and BioNTech have successfully utilized RNA technology to create vaccines, further validating the potential applications of RNA therapeutics in various diseases.

Increased Recognition of RNA Therapies

The growing recognition and acceptance of RNA therapies among healthcare professionals and stakeholders are driving the US RNA-Based Therapeutics Market Industry forward. Regulatory bodies, including the Food and Drug Administration (FDA), have accelerated the approval process for RNA-based treatments, recognizing their potential in addressing previously untreatable diseases. Recently, the FDA granted Breakthrough Therapy Designation to several RNA therapeutics aimed at rare diseases, underscoring the urgency in developing these drugs.

As a result, more pharmaceutical companies are pursuing RNA-based solutions, leading to a broader pipeline of therapies and a notable increase in market activity.

Collaborative Efforts Among Biotech Firms

The US RNA-Based Therapeutics Market Industry is significantly improved by the collaborations among biotechnology firms. The trend of partnerships for the co-development of RNA technologies has become more prevalent as companies endeavor to combine their resources and expertise. For example, the partnership between BioNTech and Pfizer underscores the potential of such partnerships to accelerate the development of RNA-based therapeutics.

These alliances are essential for navigating the intricate landscape of RNA therapeutics, as they provide access to shared technology, funding, and research capabilities. According to the Biotechnology Innovation Organization, such collaborations are predicted to continue growing, further driving innovation and market expansion in the US.

US RNA-Based Therapeutics Market Segment Insights

RNA-Based Therapeutics Market Technology Insights

The Technology segment of the US RNA-Based Therapeutics Market is characterized by significant advancements and a diverse array of applications that demonstrate the potential of RNA technologies in treating various diseases. RNA Interference has emerged as a dominant force in the market, allowing for targeted gene silencing, which is crucial in addressing genetic disorders and reducing the prevalence of certain diseases.

The ability to specifically inhibit gene expression not only has therapeutic implications but also provides a powerful tool in Research and Development studies for understanding gene functions. Antisense Oligonucleotides have garnered attention for their efficacy in modulating gene expression and are often used in the treatment of neurological conditions and rare genetic disorders.

The ability to design these oligonucleotides to target the specific RNA sequence makes them an invaluable asset in tailoring personalized medicine approaches. mRNA Therapeutics have revolutionized treatment paradigms, especially highlighted during the recent pandemic with mRNA vaccines showcasing their rapid development capabilities. These technologies enable the delivery of genetic information into cells efficiently, generating an immune response or producing therapeutic proteins necessary for disease management.

Furthermore, CRISPR Technology has redefined gene editing by providing precise and versatile tools for modifying genomes, which is essential for treating genetic disorders and advancing therapies in various fields such as oncology and agriculture. As the market evolves, these technologies drive innovation, presenting new opportunities while also facing challenges related to regulatory frameworks and ethical considerations.

The growth of these segments within the US RNA-Based Therapeutics Market illustrates the dynamic interplay of scientific progress and clinical application, underscoring the transformative potential of RNA-based solutions in healthcare.

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Source: Primary Research, Secondary Research, MRFR Database and Analyst Review

RNA-Based Therapeutics Market Application Insights

The US RNA-Based Therapeutics Market is rapidly evolving, with significant advancements in various applications including Oncology, Infectious Diseases, Genetic Disorders, and Cardiovascular Diseases. The demand for RNA-based treatments in Oncology is particularly strong due to the rising prevalence of cancer, driving research towards targeted therapies that improve patient outcomes. Infectious Diseases have also seen a surge in interest, especially highlighted by the recent global health crises, prompting the development of RNA therapies for efficient vaccine design and rapid responses.

Genetic Disorders represent another critical area, as RNA technology holds promise for addressing previously untreatable conditions by targeting gene expression and providing innovative solutions. Cardiovascular Diseases, among the leading causes of mortality in the US, benefit from RNA-based approaches aimed at gene regulation and potential interventions. Each of these applications showcases a significant opportunity within the US RNA-Based Therapeutics Market, underpinned by ongoing research and development initiatives aimed at harnessing RNA technology to treat complex health challenges effectively.

As the market progresses, these applications are likely to play a pivotal role in shaping the future of therapeutic interventions in the healthcare landscape.

RNA-Based Therapeutics Market End Use Insights

The US RNA-Based Therapeutics Market is seeing a considerable shift within its End Use segment, primarily influenced by the demand from Pharmaceutical Companies, Research Institutions, and Contract Research Organizations. Pharmaceutical Companies play a significant role in the development and commercialization of RNA-based therapies, often focusing on innovative treatment solutions that address critical medical needs. Research Institutions are crucial for advancing RNA technology and conducting essential studies that contribute to knowledge creation in this dynamic field.

These institutions often collaborate with pharmaceutical firms, facilitating the translation of research into practical applications. Contract Research Organizations provide essential services that support both pharmaceutical companies and research institutions, enabling efficiency in clinical trials and regulatory processes. Their prominence in this market stems from the increasing complexity of drug development, requiring specialized expertise and resources. As the US government continues to invest in healthcare innovation, the entire RNA-based therapeutics ecosystem is poised for growth, fueled by advances in genetic research and personalized medicine.

This segment's contributions are vital for driving market trends and enhancing patient outcomes across various therapeutic areas.

RNA-Based Therapeutics Market Delivery Method Insights

The Delivery Method segment of the US RNA-Based Therapeutics Market is crucial for the effective transport of therapeutic agents to target cells. Various techniques are utilized within this segment, including Liposomes, Nanoparticles, Viral Vectors, and Electroporation, each with its unique advantages. Liposomes often increase the stability and bioavailability of RNA-based drugs, enhancing their therapeutic efficacy. Nanoparticles are valued for their ability to facilitate cellular uptake and enable targeted delivery, overcoming barriers often faced by traditional delivery methods.

Viral Vectors leverage the natural ability of viruses to deliver genetic material into cells, making them a powerful tool for gene therapy. Electroporation employs electric fields to enhance cell permeability, allowing for more efficient delivery of RNA molecules. The growth in this segment is supported by increasing investments in innovative drug delivery technologies and advances in Research and Development. Continued focus on improving delivery efficiency and patient outcomes indicates promising opportunities within the US RNA-Based Therapeutics Market, further emphasizing the significance of the Delivery Method segment in shaping future therapeutic landscapes.

US RNA-Based Therapeutics Market Key Players and Competitive Insights

The US RNA-Based Therapeutics Market has experienced a surge in innovation and competition, reflecting the growing significance of RNA technologies in drug development. This market encompasses a range of therapeutic modalities that utilize RNA as a central component in targeting diseases, particularly genetic disorders, cancers, and infectious diseases. Increasing investments from both public and private sectors, advancements in delivery mechanisms, and a favorable regulatory environment have contributed to the rapid growth of this market.

Companies operating within this space have been focusing on developing novel therapeutics that leverage messenger RNA (mRNA), small interfering RNA (siRNA), and other RNA-based platforms to address unmet medical needs. As the landscape evolves, understanding the competitive dynamics among key players will be essential for stakeholders looking to navigate this promising market.

CureVac has positioned itself as a notable player in the US RNA-Based Therapeutics Market, particularly with its focus on mRNA technology to develop innovative vaccines and therapeutics. The company’s strength lies in its proprietary mRNA technology platform, which is designed to enable the creation of a diverse range of treatments, including those for oncology and infectious diseases. CureVac has established a strong presence in the US through strategic collaborations with various biopharmaceutical firms and research institutions, allowing it to leverage additional expertise and resources.

The company’s focus on achieving high efficacy and safety profiles in its RNA-based therapeutics has garnered attention from both investors and healthcare professionals, contributing to its continued growth and innovation in this competitive arena. BioNTech has emerged as a leading force in the US RNA-Based Therapeutics Market, particularly noted for its breakthrough mRNA therapies and vaccines. The company gained significant recognition with its rapid development of an mRNA-based COVID-19 vaccine, showcasing the potential of RNA technologies in responding to urgent public health challenges.

BioNTech's strength lies not only in its cutting-edge scientific capabilities but also in its established partnerships with major pharmaceutical companies, enhancing its development and commercialization efforts in the US market. The company continues to expand its pipeline, targeting various therapeutic areas such as oncology and autoimmune diseases, providing a robust array of products that cater to diverse patient populations. BioNTech's strategic mergers and acquisitions have also enabled it to bolster its capabilities in RNA science, thereby reinforcing its competitive position in the US RNA-Based Therapeutics Market and ensuring a strong foothold as the landscape continues to evolve.

Key Companies in the US RNA-Based Therapeutics Market Include

• CureVac


• BioNTech


• Alnylam Pharmaceuticals


• Ionis Pharmaceuticals


• Regeneron Pharmaceuticals


• Moderna


• Sangamo Therapeutics


• Pfizer


• Novartis


• Sanofi


• Intellia Therapeutics


• Vertex Pharmaceuticals


• Wave Life Sciences


• Translate Bio


• Arcturus Therapeutics

US RNA-Based Therapeutics Market Industry Developments

The US RNA-Based Therapeutics Market has seen significant developments recently. Companies like Moderna and BioNTech continue to expand their mRNA technology beyond vaccines, focusing on treatments for a range of diseases, including cancer and rare genetic disorders. In November 2023, Alnylam Pharmaceuticals announced promising results from a Phase III trial for its RNA interference therapy, which has fueled investor interest and boosted its market valuation significantly.

In terms of mergers and acquisitions, in September 2023, Sanofi completed the acquisition of Translate Bio, enhancing its capabilities in mRNA technology for therapeutic applications. Additionally, in October 2023, Pfizer announced a partnership with BioNTech to develop combined RNA-based therapies that target infectious diseases, reflecting a growing trend towards collaboration in this sector. Government initiatives are also supporting the RNA therapeutics field, with recent funding allocated for Research and Development in genetic medicine.

Over the past few years, the US market's momentum has accelerated, fueled by an increased focus on personalized medicine and innovations in delivery systems for RNA-based drugs. With ongoing advancements and strategic collaborations, the outlook for the US RNA-Based Therapeutics Market remains robust.

RNA-Based Therapeutics Market Segmentation Insights

RNA-Based Therapeutics Market Technology Outlook

• RNA Interference


• Antisense Oligonucleotides


• mRNA Therapeutics


• CRISPR Technology

RNA-Based Therapeutics Market Application Outlook

• Oncology


• Infectious Diseases


• Genetic Disorders


• Cardiovascular Diseases

RNA-Based Therapeutics Market End Use Outlook

• Pharmaceutical Companies


• Research Institutions


• Contract Research Organizations

RNA-Based Therapeutics Market Delivery Method Outlook

• Liposomes


• Nanoparticles


• Viral Vectors


• Electroporation

Report Attribute/Metric	Details
Market Size 2023	1.62(USD Billion)
Market Size 2024	2.0(USD Billion)
Market Size 2035	6.5(USD Billion)
Compound Annual Growth Rate (CAGR)	11.31% (2025 - 2035)
Report Coverage	Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
Base Year	2024
Market Forecast Period	2025 - 2035
Historical Data	2019 - 2024
Market Forecast Units	USD Billion
Key Companies Profiled	CureVac, BioNTech, Alnylam Pharmaceuticals, Ionis Pharmaceuticals, Regeneron Pharmaceuticals, Moderna, Sangamo Therapeutics, Pfizer, Novartis, Sanofi, Intellia Therapeutics, Vertex Pharmaceuticals, Wave Life Sciences, Translate Bio, Arcturus Therapeutics
Segments Covered	Technology, Application, End Use, Delivery Method
Key Market Opportunities	Increasing demand for gene therapies, Advancements in RNA delivery systems, Growing prevalence of genetic disorders, Rise in personalized medicine approaches, Expanding investment in biotech innovation
Key Market Dynamics	Increasing prevalence of genetic disorders, Advancements in delivery technologies, Growing investment in R&D, Regulatory support for innovation, Rising patient awareness and demand
Countries Covered	US