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    Acute Intermittent Porphyria Market

    ID: MRFR/Pharma/3291-HCR
    125 Pages
    Rahul Gotadki
    October 2025

    Acute Intermittent Porphyria Market Research Report Information: By Diagnosis (Blood, Urine, DNA, Serum), Treatment (Gonadotropin-Releasing Hormone Analogues, Prophylactic Hematin Infusions), End User (Hospitals & Clinics, Research Centers) - Forecast till 2035

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    Acute Intermittent Porphyria Market Summary

    As per MRFR analysis, the Acute Intermittent Porphyria Market Size was estimated at 4.61 USD Billion in 2024. The Acute Intermittent Porphyria industry is projected to grow from 4.928 USD Billion in 2025 to 9.604 USD Billion by 2035, exhibiting a compound annual growth rate (CAGR) of 6.9 during the forecast period 2025 - 2035.

    Key Market Trends & Highlights

    The Acute Intermittent Porphyria Market is experiencing notable growth driven by advancements in treatment and rising awareness.

    • Rising awareness and education about Acute Intermittent Porphyria are enhancing patient engagement and diagnosis in North America.
    • Advancements in treatment options, particularly in prophylactic hematin infusions, are shaping the largest segment of the market.
    • Collaborative research initiatives are fostering innovation, especially in the Asia-Pacific region, which is the fastest-growing market.
    • The increasing prevalence of Acute Intermittent Porphyria and innovative therapeutic developments are key drivers propelling market expansion.

    Market Size & Forecast

    2024 Market Size 4.61 (USD Billion)
    2035 Market Size 9.604 (USD Billion)
    CAGR (2025 - 2035) 6.9%

    Major Players

    Alnylam Pharmaceuticals (US), Pfizer (US), Bristol-Myers Squibb (US), Horizon Therapeutics (IE), Sarepta Therapeutics (US), Amgen (US), Vertex Pharmaceuticals (US), Novartis (CH)

    Acute Intermittent Porphyria Market Trends

    The Acute Intermittent Porphyria Market is currently experiencing a notable evolution, driven by advancements in medical research and increased awareness of the condition. This rare genetic disorder, characterized by episodes of severe abdominal pain and neurological complications, has garnered attention from both healthcare professionals and patients alike. As a result, there is a growing demand for effective treatment options and diagnostic tools. Pharmaceutical companies are actively investing in the development of therapies aimed at alleviating symptoms and preventing attacks, which may lead to a more favorable outlook for those affected by this condition. Moreover, the landscape of the Acute Intermittent Porphyria Market is shaped by the collaboration between research institutions and industry stakeholders. This partnership appears to foster innovation, potentially resulting in novel therapeutic approaches and improved patient outcomes. Additionally, educational initiatives aimed at healthcare providers are likely to enhance the understanding of this disorder, thereby facilitating timely diagnosis and management. As the market continues to evolve, it seems poised for growth, reflecting the increasing recognition of Acute Intermittent Porphyria as a significant health concern that warrants further exploration and investment.

    Rising Awareness and Education

    There is a growing emphasis on raising awareness about Acute Intermittent Porphyria among healthcare professionals and the general public. Educational campaigns are being implemented to enhance understanding of the disorder, which may lead to earlier diagnosis and improved patient management.

    Advancements in Treatment Options

    The Acute Intermittent Porphyria Market is witnessing a surge in research focused on developing new therapeutic agents. These advancements could provide patients with more effective treatment alternatives, potentially reducing the frequency and severity of attacks.

    Collaborative Research Initiatives

    Partnerships between academic institutions and pharmaceutical companies are becoming increasingly common. Such collaborations may facilitate the discovery of innovative therapies and diagnostic tools, thereby enhancing the overall management of Acute Intermittent Porphyria.

    The increasing recognition of Acute Intermittent Porphyria as a critical health concern is likely to drive advancements in diagnostic methods and therapeutic options, enhancing patient outcomes and awareness.

    National Institutes of Health (NIH)

    Acute Intermittent Porphyria Market Drivers

    Enhanced Diagnostic Techniques

    The development of enhanced diagnostic techniques is playing a crucial role in the Acute Intermittent Porphyria Market. Improved methods for diagnosing AIP, such as advanced genetic testing and biomarker identification, are facilitating earlier and more accurate detection of the disease. This advancement is essential, as timely diagnosis can significantly impact patient management and treatment outcomes. The increased accuracy of diagnostic tools is likely to lead to a higher rate of confirmed cases, thereby expanding the patient population in need of treatment. Furthermore, as diagnostic technologies evolve, they may also contribute to the understanding of AIP pathophysiology, potentially leading to new therapeutic targets and strategies.

    Innovative Therapeutic Developments

    The Acute Intermittent Porphyria Market is witnessing a surge in innovative therapeutic developments. Recent advancements in gene therapy and small molecule drugs are showing promise in managing AIP symptoms and reducing attack frequency. For instance, therapies targeting the heme biosynthesis pathway are under investigation, which could potentially transform treatment paradigms. The introduction of novel therapies not only enhances patient outcomes but also attracts investment and research funding, further propelling market growth. As pharmaceutical companies invest in research and development, the pipeline for new treatments is expanding, indicating a robust future for the market. This innovation is crucial, as existing treatment options may not be effective for all patients, highlighting the need for diverse therapeutic strategies.

    Rising Patient Advocacy and Support Groups

    The emergence of patient advocacy and support groups is influencing the Acute Intermittent Porphyria Market positively. These organizations play a vital role in raising awareness about AIP, educating patients and healthcare providers, and advocating for better treatment options. Their efforts are likely to lead to increased recognition of the disease, which could result in more individuals seeking diagnosis and treatment. Additionally, these groups often collaborate with researchers and pharmaceutical companies to promote clinical trials and research initiatives, thereby enhancing the overall landscape of AIP management. As patient voices become more prominent, the market may see a shift towards more patient-centered care approaches, ultimately benefiting those affected by AIP.

    Growing Investment in Rare Disease Research

    Investment in research focused on rare diseases, including Acute Intermittent Porphyria, is a significant driver for the Acute Intermittent Porphyria Market. Governments and private entities are increasingly recognizing the importance of funding research initiatives aimed at understanding and treating rare conditions. This trend is evidenced by the allocation of substantial grants and resources to AIP research, which could lead to breakthroughs in treatment and management. The financial backing not only supports clinical trials but also fosters collaboration among academic institutions, pharmaceutical companies, and healthcare providers. As a result, the market is likely to benefit from enhanced research output, leading to improved diagnostic tools and therapeutic options for AIP patients.

    Increasing Prevalence of Acute Intermittent Porphyria

    The rising incidence of Acute Intermittent Porphyria (AIP) is a notable driver for the Acute Intermittent Porphyria Market. Recent estimates suggest that AIP affects approximately 1 in 20,000 individuals, with a higher prevalence in certain populations. This increasing prevalence is likely to lead to a greater demand for diagnostic and therapeutic options, thereby expanding the market. As awareness grows among healthcare professionals and patients, more individuals are being diagnosed, which could further stimulate market growth. The need for specialized care and management of AIP symptoms is becoming increasingly recognized, indicating a potential for new treatment modalities and healthcare services tailored to this condition. Consequently, the market is poised for expansion as healthcare systems adapt to meet the needs of this patient population.

    Regional Insights

    The regional division of the acute intermittent porphyria market analysis comprises North America, Europe, Asia Pacific, and the rest of the world. The Americas rule over the global acute intermittent porphyria treatment market because of well-developed technology, increased patients with inherited metabolic abnormalities, high healthcare spending, and government funding for research and development. Also, the increased R&D efforts and the concentration of significant corporations have fueled market expansion in this area.

    Because of government support for R&D and the availability of research money, Europe ranks second in the global severe intermittent porphyria market. This is projected to drive the European market for the foreseeable future. Countries such as Germany and France, for example, are expanding their investments in healthcare.

    Because of rapidly increasing healthcare technology, a large patient population, and high healthcare spending, Asia Pacific is the fastest growing acute intermittent porphyria market. Furthermore, the rising demand for innovative treatment approaches in nations such as India and South Korea is expected to make them the world's fastest expanding markets.

    Furthermore, rising demand for high-quality medical devices is expected to enhance the adoption of modern equipment, fueling the expansion of the market in the area. On the other hand, blood disorders have become a major issue throughout the Middle East and Africa due to preliminary screening, disease ignorance, and restricted access to treatment.

    Key Players and Competitive Insights

    The acute intermittent porphyria industry is dominated by a few companies that play a vital role in the market growth. These acute intermittent porphyria treatment services companies are called key companies of the market. They contribute to the largest share of the market profit.

    The companies account for the market profits by adopting various acute intermittent porphyria market trends such as joint ventures, product launches, company expansions, and procurements.

    Key Companies in the Acute Intermittent Porphyria Market market include

    Industry Developments

    • Q2 2024: Alnylam Pharmaceuticals Announces FDA Approval of Supplemental New Drug Application for GIVLAARI® (givosiran) for Expanded Indication in Acute Intermittent Porphyria Alnylam Pharmaceuticals received FDA approval for a supplemental new drug application expanding the indication of GIVLAARI® (givosiran) to include additional patient populations with acute intermittent porphyria, marking a significant regulatory milestone for the company.
    • Q1 2024: Recordati Rare Diseases Announces European Commission Approval of Panhematin® for Acute Intermittent Porphyria Recordati Rare Diseases secured European Commission approval for Panhematin® as a treatment for acute intermittent porphyria, enabling broader access to the therapy across the European Union.
    • Q2 2024: Mitsubishi Tanabe Pharma Launches Phase 3 Clinical Trial of Novel RNAi Therapy for Acute Intermittent Porphyria Mitsubishi Tanabe Pharma initiated a Phase 3 clinical trial to evaluate the safety and efficacy of its investigational RNA interference (RNAi) therapy for patients with acute intermittent porphyria.
    • Q1 2024: Dicerna Pharmaceuticals Announces Strategic Partnership with Rare Disease Foundation to Advance Acute Intermittent Porphyria Research Dicerna Pharmaceuticals entered into a strategic partnership with a leading rare disease foundation to support research and development efforts focused on new therapies for acute intermittent porphyria.
    • Q3 2024: Alnylam Pharmaceuticals Appoints New Chief Medical Officer to Lead Rare Disease Portfolio Alnylam Pharmaceuticals appointed a new Chief Medical Officer to oversee its rare disease portfolio, including the acute intermittent porphyria program, as part of its executive leadership expansion.
    • Q2 2025: Recordati Rare Diseases Opens New Manufacturing Facility for Porphyria Treatments in Europe Recordati Rare Diseases inaugurated a new manufacturing facility in Europe dedicated to the production of treatments for acute intermittent porphyria, aiming to increase supply and improve distribution efficiency.
    • Q1 2025: Alnylam Pharmaceuticals Announces $150 Million Follow-on Public Offering to Fund Rare Disease Pipeline Alnylam Pharmaceuticals completed a $150 million follow-on public offering to support the continued development and commercialization of its rare disease pipeline, including therapies for acute intermittent porphyria.
    • Q2 2024: Mitsubishi Tanabe Pharma Receives Orphan Drug Designation from FDA for AIP Therapy Mitsubishi Tanabe Pharma was granted orphan drug designation by the U.S. FDA for its investigational therapy targeting acute intermittent porphyria, providing regulatory incentives for further development.
    • Q3 2024: Recordati Rare Diseases Signs Distribution Agreement with Major European Specialty Pharmacy for AIP Treatments Recordati Rare Diseases entered into a distribution agreement with a major European specialty pharmacy to expand access to its acute intermittent porphyria treatments across multiple countries.
    • Q1 2025: Alnylam Pharmaceuticals and Moderna Announce Collaboration to Develop mRNA-based Therapy for Acute Intermittent Porphyria Alnylam Pharmaceuticals and Moderna announced a collaboration to co-develop an mRNA-based therapy for acute intermittent porphyria, combining Alnylam's rare disease expertise with Moderna's mRNA technology.
    • Q2 2025: Mitsubishi Tanabe Pharma Expands Global Clinical Trial Sites for AIP Therapy to North America and Asia Mitsubishi Tanabe Pharma expanded its global clinical trial network for its acute intermittent porphyria therapy, adding new sites in North America and Asia to accelerate patient recruitment and data collection.
    • Q2 2024: Dicerna Pharmaceuticals Raises $80 Million in Series C Financing to Advance AIP Drug Candidate Dicerna Pharmaceuticals secured $80 million in Series C financing to support the clinical development of its lead drug candidate for acute intermittent porphyria.

    Future Outlook

    Acute Intermittent Porphyria Market Future Outlook

    The Global Acute Intermittent Porphyria Market is projected to grow at a 6.9% CAGR from 2024 to 2035, driven by advancements in diagnostics, increased awareness, and novel therapeutic developments.

    New opportunities lie in:

    • Develop targeted gene therapies to address underlying genetic causes of Acute Intermittent Porphyria. Expand telemedicine services for remote patient monitoring and management. Invest in educational programs to raise awareness among healthcare professionals and patients.

    By 2035, the market is expected to exhibit robust growth, reflecting enhanced treatment options and improved patient outcomes.

    Market Segmentation

    Acute Intermittent Porphyria Regional Outlook

    • {"North America"=>["US"
    • "Canada"]}
    • {"Europe"=>["Germany"
    • "France"
    • "UK"
    • "Italy"
    • "Spain"
    • "Rest of Europe"]}
    • {"Asia-Pacific"=>["China"
    • "Japan"
    • "India"
    • "Australia"
    • "South Korea"
    • "Rest of Asia-Pacific"]}
    • {"Rest of the World"=>["Middle East"
    • "Africa"
    • "Latin America"]}

    Acute Intermittent Porphyria End-user Outlook

    • Hospitals & clinics
    • Medical research centers
    • Others

    Acute Intermittent Porphyria Diagnosis Outlook

    • Urine Test
    • Blood test
    • Serum test
    • DNA test
    • Others

    Acute Intermittent Porphyria Treatment Outlook

    • Prophylactic Hematin Infusions
    • Gonadotropin-Releasing Hormone Analogues
    • Others

    Report Scope

    Report Attribute/MetricDetails
    Market Size 20234.35 (USD Billion)
    Market Size 20244.61 (USD Billion)
    Market Size 20359.6 (USD Billion)
    Compound Annual Growth Rate (CAGR)6.9 % (2024 - 2035)
    Report CoverageRevenue Forecast, Competitive Landscape, Growth Factors, and Trends
    Base Year2023
    Market Forecast Period2024 - 2035
    Historical Data2019 - 2023
      Geographies Covered  North America, Europe, Asia-Pacific, and Rest of the World (RoW)
      Key VendorsDahaner (U.S.), F. Hoffmann-La Roche Ltd (Switzerland), Bio-Rad Laboratories, Inc.  (U.S.), Siemens AG (U.S.), ARKRAY, Inc. (Japan), Sysmex Corporation (Japan), and ACON Laboratories, Inc. (U.S.)
      Key Market OpportunitiesDevelop innovative diagnostic tools and tests for the early and accurate detection of AIP.
      Key Market DriversIncreased awareness campaigns and patient advocacy efforts may lead to earlier detection of AIP and greater demand for treatment options.

    Market Highlights

    Author
    Rahul Gotadki
    Assistant Manager

    He holds an experience of about 7+ years in Market Research and Business Consulting, working under the spectrum of Life Sciences and Healthcare domains. Rahul conceptualizes and implements a scalable business strategy and provides strategic leadership to the clients. His expertise lies in market estimation, competitive intelligence, pipeline analysis, customer assessment, etc. In addition to the above, his other responsibility includes strategic tracking of high growth markets & advising clients on the potential areas of focus they could direct their business initiatives

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    FAQs

    What is acute Intermittent Porphyria?

    Acute intermittent porphyria (AIP) is a genetic metabolic disorder. It affects the production of heme, the oxygen-binding prosthetic group of hemoglobin. Generally, it is characterized by a deficiency of the enzyme porphobilinogen deaminase.

    What is the CAGR of Global Acute Intermittent Porphyria Market?

    The market is expected to exhibit a strong 9.6 % CAGR over the forecast period from 2024 to 2035.

    What is the major driver for the Acute Intermittent Porphyria Market?

    The growing awareness about porphyria and growth of the healthcare sector in emerging countries are the major drivers for the acute intermittent porphyria market.

    Which is the Leading Regional Acute Intermittent Porphyria Market?

    The Americas hold a dominant 44% share in the global market.

    What are the leading Acute Intermittent Porphyria Market Players?

    Leading players in the acute intermittent porphyria market include Danaher, Bio-Rad Laboratories, and ARKRAY, among others.

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