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US Healthcare Cold Chain Logistics Market

ID: MRFR/HC/43353-HCR
200 Pages
Rahul Gotadki
October 2025

US Healthcare Cold Chain Logistics Market Size, Growth Research Report By Mode of Delivery (Last-Mile Delivery, Hubs-to-Distributor), By Product (Vaccines, Biopharmaceuticals, Clinical Trial Materials), By Services (Transportation, Storage, Packaging, Labeling, Others), By End User (Hospitals Clinics, Pharmaceutical, Biopharmaceutical, Biotechnology Companies, Others) and By Temperature Range (Ambient, Refrigerated, Frozen, Cryogenic) - Competitor Industry Analysis and Trends Forecast Till 2035

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US Healthcare Cold Chain Logistics Market Summary

As per analysis, the US healthcare cold chain logistics market is projected to grow from USD 1,290.75 Million in 2025 to USD 2,027.68 Million by 2035, exhibiting a compound annual growth rate (CAGR) of 4.62% during the forecast period (2025 - 2035).

Key Market Trends & Highlights

The US healthcare cold chain logistics market is poised for growth driven by technological advancements and increasing demand for biopharmaceuticals.

  • Technological advancements in cold chain monitoring are enhancing the efficiency and reliability of logistics operations.
  • The pharmaceutical segment remains the largest contributor to the market, while the vaccine segment is experiencing the fastest growth.
  • Hospitals represent the largest end-user of cold chain logistics, with research laboratories emerging as the fastest-growing segment.
  • Rising demand for biopharmaceuticals and a focus on regulatory compliance are key drivers propelling market expansion.

Market Size & Forecast

2024 Market Size 1233.75 (USD Million)
2035 Market Size 2027.68 (USD Million)
CAGR (2025 - 2035) 4.62%

Major Players

Thermo Fisher Scientific (US), UPS Healthcare (US), FedEx Healthcare (US), DHL Supply Chain (US), McKesson Corporation (US), Cardinal Health (US), AmerisourceBergen (US), Panalpina (US), Kuehne + Nagel (US)

US Healthcare Cold Chain Logistics Market Trends

The US healthcare cold chain logistics market is currently experiencing notable transformations driven by advancements in technology and increasing regulatory requirements. The demand for temperature-sensitive products, such as vaccines, biologics, and pharmaceuticals, necessitates a robust cold chain infrastructure. This market appears to be evolving as stakeholders prioritize compliance with stringent guidelines set forth by regulatory bodies. Enhanced tracking and monitoring systems are being integrated to ensure product integrity throughout the supply chain, which is crucial for maintaining efficacy and safety. Furthermore, the rise of e-commerce in the healthcare sector is reshaping distribution strategies, compelling logistics providers to adapt to new consumer expectations and delivery models. In addition, sustainability concerns are becoming increasingly prominent within the US healthcare cold chain logistics market. Companies are exploring eco-friendly packaging solutions and energy-efficient transportation methods to minimize their environmental footprint. This shift towards greener practices may not only enhance corporate responsibility but also align with consumer preferences for sustainable products. As the market continues to develop, it is likely that innovation and adaptability will play pivotal roles in shaping the future landscape of cold chain logistics in the healthcare sector.

Technological Advancements in Cold Chain Monitoring

The integration of advanced technologies, such as IoT and blockchain, is transforming the US healthcare cold chain logistics market. These innovations facilitate real-time monitoring of temperature-sensitive products, ensuring compliance with regulatory standards. Enhanced visibility throughout the supply chain may lead to improved efficiency and reduced waste, as stakeholders can promptly address any deviations in temperature.

Regulatory Compliance and Quality Assurance

Stringent regulations governing the transportation of pharmaceuticals and biologics are driving the need for robust quality assurance measures in the US healthcare cold chain logistics market. Companies are increasingly investing in training and certification programs to ensure adherence to these regulations. This focus on compliance not only safeguards product integrity but also builds trust with consumers and healthcare providers.

Sustainability Initiatives in Logistics Operations

The growing emphasis on sustainability is influencing practices within the US healthcare cold chain logistics market. Companies are exploring environmentally friendly packaging and energy-efficient transportation options. This shift towards sustainable logistics may not only reduce environmental impact but also resonate with a consumer base that increasingly values corporate responsibility.

Market Segment Insights

By Application: Pharmaceuticals (Largest) vs. Vaccines (Fastest-Growing)

In the US healthcare cold chain logistics market, the application segment is predominantly defined by pharmaceuticals, which hold the largest share, benefiting from the increasing demand for temperature-sensitive medications. Biologics and clinical trials also contribute significantly to this sector, and while they are essential, they occupy smaller market positions compared to pharmaceuticals. Vaccines represent a rapidly growing area within this market, driven by public health initiatives and the continued development of new immunizations.

Pharmaceuticals: Dominant vs. Vaccines: Emerging

Pharmaceuticals are a dominant force in the US healthcare cold chain logistics market, characterized by their strict compliance with temperature control regulations and evolving packaging technologies to ensure product integrity. As the demand for advanced therapies increases, associated logistics solutions also evolve. Vaccines, while representing an emerging category, are experiencing accelerated growth due to the recent focus on immunization efforts, particularly in the wake of global health challenges. The logistics of vaccine distribution requires specialized storage and handling capabilities, fostering innovation within the sector. As health policies evolve, both segments continue to adapt to meet industry standards.

By End Use: Hospitals (Largest) vs. Research Laboratories (Fastest-Growing)

In the US healthcare cold chain logistics market, hospitals account for the largest share, effectively managing extensive inventories of temperature-sensitive medicines and biological samples. Their established infrastructure and the critical need for reliable logistics support their leading position, showcasing a robust network of refrigerated transportation. Following closely are pharmacies, which also play a vital role in this sector. Research laboratories are gaining traction with the introduction of innovative therapies and clinical trials, edging them towards significant market share as the demand increases for specialized handling.

Hospitals (Dominant) vs. Research Laboratories (Emerging)

Hospitals represent a dominant force in the US healthcare cold chain logistics market, characterized by their vast network that ensures the safe transportation of vaccines and other temperature-controlled pharmaceuticals. They utilize advanced tracking technologies and stringent protocols to maintain the integrity of sensitive products. Research laboratories, while emerging, are rapidly advancing due to their pivotal role in developing new medical solutions. The growth in biopharmaceutical research and the need for precise cold chain solutions to protect experimental samples are propelling laboratories into a vital position, emphasizing their importance in the evolving landscape of healthcare logistics.

By Temperature Range: Refrigerated (Largest) vs. Frozen (Fastest-Growing)

The US healthcare cold chain logistics market is characterized by a diverse range of temperature-controlled segments. Among these, the 'Refrigerated' segment holds the largest market share, mainly due to its critical role in the transportation of pharmaceuticals such as vaccines and biologics that require consistent temperature maintenance. Following this, the 'Frozen' segment is gaining traction, attributed to the increasing demand for freeze-dried products and the need for transporting specific therapeutic products under stringent conditions. In terms of growth trends, the 'Frozen' segment is identified as the fastest-growing. This growth is driven by advancements in cryogenic technologies and a rising patient population necessitating biopharmaceuticals that often require significant cold storage. Additionally, heightened regulatory standards surrounding the preservation of temperature-sensitive medical products further propel the demand for efficient frozen transport solutions, making it an emerging focus area within the overall logistics framework.

Refrigerated: Dominant vs. Cryogenic: Emerging

The 'Refrigerated' segment in the US healthcare cold chain logistics market is the dominant force due to its widespread application and established infrastructure. It serves a vital role in the distribution of temperature-sensitive medical products, ensuring efficacy and safety during transport. On the other hand, the 'Cryogenic' segment is recognized as an emerging player, primarily driven by innovations in preservation techniques and the increasing prevalence of advanced therapies such as gene and cell therapies that demand ultra-low temperatures for storage. While refrigerated solutions maintain temperatures of 2 to 8 degrees Celsius, cryogenic options utilize liquid nitrogen or other means to achieve far lower temperatures. As research in life sciences accelerates, the need for both segments will likely grow, each addressing specific logistical needs within the healthcare sector.

By Packaging Type: Insulated Containers (Largest) vs. Thermal Pallets (Fastest-Growing)

In the US healthcare cold chain logistics market, the segment of packaging type is characterized by a diverse distribution of market share among several key players. Insulated containers dominate this segment due to their reliability in maintaining temperature-sensitive products during transit. They are widely used for pharmaceuticals and biologics that require strict temperature control. Following closely, thermal pallets and temperature-controlled boxes are also gaining traction, catering to the unique needs of large shipments and sensitive materials, respectively. Active containers, although smaller in share, are essential for specific high-value products that require continuous temperature monitoring. Recent growth trends in this segment are driven by the increasing demand for efficient cold chain solutions in healthcare. The rise of biopharmaceuticals and personalized medicine has heightened the need for robust packaging solutions that can accommodate varying temperature requirements. Additionally, advancements in insulation materials and technologies have enabled packaging manufacturers to enhance their products' performance, leading to an uptick in adoption rates. Overall, the focus on temperature integrity and compliance within the healthcare sector continues to drive innovation and investment in packaging types within cold chain logistics.

Insulated Containers (Dominant) vs. Active Containers (Emerging)

Insulated containers represent the dominant force in the US healthcare cold chain logistics market, prized for their effectiveness in preserving the integrity of temperature-sensitive products. These containers are designed to maintain consistent internal temperatures, essential for transporting pharmaceuticals, vaccines, and biological materials. In contrast, active containers, though considered an emerging segment, are making significant strides with their cutting-edge technology that actively manages temperature fluctuations through battery-powered systems. While insulated containers are mainly passive, relying on thermal insulation, active containers offer a more dynamic solution, ensuring that products remain within critical temperature ranges throughout transportation. This emerging technology is particularly attractive for high-value products that demand strict temperature adherence and may drive increased adoption among logistics providers.

By Transport Mode: Air Freight (Largest) vs. Road Transport (Fastest-Growing)

In the US healthcare cold chain logistics market, the transport mode segment showcases distinct preferences among stakeholders. Air freight currently holds the largest market share, particularly favored for its ability to quickly deliver temperature-sensitive products such as vaccines and critical medications. Road transport follows closely, leveraging extensive infrastructure for regional distribution and providing flexibility in short-haul deliveries.

Air Freight (Dominant) vs. Road Transport (Emerging)

Air freight emerges as the dominant mode of transport, essential for time-sensitive healthcare deliveries. Its unmatched speed ensures that critical supplies reach their destinations rapidly, crucial for patient care. In contrast, road transport is an emerging player, providing flexibility and access to varied locations. With advancements in refrigerated vehicle technologies, road transport is becoming increasingly reliable for last-mile deliveries and remains a pivotal element in the overall cold chain logistics strategy.

Get more detailed insights about US Healthcare Cold Chain Logistics Market

Key Players and Competitive Insights

The healthcare cold chain logistics market is characterized by a dynamic competitive landscape, driven by the increasing demand for temperature-sensitive pharmaceuticals and biologics. Key players such as Thermo Fisher Scientific (US), UPS Healthcare (US), and FedEx Healthcare (US) are strategically positioned to leverage their extensive networks and technological capabilities. For instance, Thermo Fisher Scientific (US) focuses on innovation in temperature-controlled packaging solutions, enhancing its service offerings to meet the stringent requirements of the healthcare sector. Meanwhile, UPS Healthcare (US) emphasizes its commitment to sustainability and efficiency, integrating advanced tracking technologies to optimize supply chain operations. Collectively, these strategies contribute to a competitive environment that prioritizes reliability and responsiveness in logistics services.

The market structure appears moderately fragmented, with several players vying for market share through localized manufacturing and supply chain optimization. Companies are increasingly localizing their operations to reduce lead times and enhance service delivery. This trend is indicative of a broader strategy among key players to streamline their logistics processes, thereby improving overall efficiency. The collective influence of these companies shapes a competitive landscape where agility and adaptability are paramount, allowing them to respond effectively to the evolving needs of the healthcare sector.

In November 2025, FedEx Healthcare (US) announced the expansion of its temperature-controlled facilities in key metropolitan areas, a move aimed at enhancing its capacity to handle the growing volume of temperature-sensitive shipments. This strategic expansion is likely to bolster FedEx's market position by improving service levels and reducing transit times, thereby addressing the increasing demands of healthcare providers for reliable logistics solutions. The investment in infrastructure reflects a commitment to maintaining high standards of service in a competitive market.

In October 2025, UPS Healthcare (US) launched a new digital platform designed to provide real-time visibility into the cold chain logistics process. This initiative is significant as it enhances transparency and allows healthcare providers to monitor their shipments closely, thereby ensuring compliance with regulatory standards. The integration of digital tools into logistics operations is indicative of a broader trend towards digital transformation within the industry, which is likely to redefine customer expectations and service delivery.

In September 2025, Cardinal Health (US) entered into a strategic partnership with a leading technology firm to develop AI-driven solutions for optimizing cold chain logistics. This collaboration aims to leverage artificial intelligence to predict demand fluctuations and optimize inventory management. The strategic importance of this partnership lies in its potential to enhance operational efficiency and reduce costs, positioning Cardinal Health as a forward-thinking player in the market.

As of December 2025, the competitive trends in the healthcare cold chain logistics market are increasingly defined by digitalization, sustainability, and the integration of advanced technologies such as AI. Strategic alliances are becoming more prevalent, enabling companies to pool resources and expertise to enhance service offerings. The shift from price-based competition to a focus on innovation, technology, and supply chain reliability is evident, suggesting that future competitive differentiation will hinge on the ability to deliver superior service and adapt to the rapidly changing landscape.

Industry Developments

In recent months, the U.S. Healthcare Cold Chain Logistics Market has observed significant developments. Companies such as UPS and FedEx have enhanced their cold storage solutions and transportation capacities in response to the increasing demand for temperature-sensitive pharmaceuticals and vaccines. As of September 2023, Thermo Fisher Scientific announced an expansion of its cold chain capabilities, which aligns with the rising trend of biological and biosimilar product shipments.

Additionally, Lineage Logistics has reported investments to optimize storage solutions that meet stringent regulatory requirements for biopharmaceuticals.Mergers and acquisitions have also been notable in this sector; for instance, in August 2023, AmerisourceBergen completed its acquisition of a major cold chain-focused logistics provider, reinforcing its position in the healthcare supply chain. Meanwhile, Cardinal Health has strategic partnerships with companies like DB Schenker to enhance logistical efficiencies.

The market has witnessed a growth trajectory, with new investments driving innovation in tracking and monitoring technologies, increasing overall operational transparency. These advancements reflect a robust response to the ongoing challenges of supply chain disruptions experienced since the COVID-19 pandemic. The U.S. government continues to emphasize robust logistics frameworks as critical to the resilience of healthcare supply chains.

U.S.

Future Outlook

US Healthcare Cold Chain Logistics Market Future Outlook

The US healthcare cold chain logistics market is projected to grow at a 4.62% CAGR from 2024 to 2035, driven by technological advancements, regulatory compliance, and increasing demand for temperature-sensitive products.

New opportunities lie in:

  • Investment in IoT-enabled temperature monitoring systems
  • Expansion of automated storage and retrieval solutions
  • Development of specialized packaging for biologics and pharmaceuticals

By 2035, the market is expected to be robust, driven by innovation and increased demand.

Market Segmentation

US Healthcare Cold Chain Logistics Market End Use Outlook

  • Hospitals
  • Pharmacies
  • Research Laboratories
  • Distribution Centers

US Healthcare Cold Chain Logistics Market Application Outlook

  • Pharmaceuticals
  • Biologics
  • Clinical Trials
  • Vaccines

US Healthcare Cold Chain Logistics Market Packaging Type Outlook

  • Insulated Containers
  • Thermal Pallets
  • Temperature-Controlled Boxes
  • Active Containers

US Healthcare Cold Chain Logistics Market Transport Mode Outlook

  • Air Freight
  • Road Transport
  • Sea Freight
  • Rail Transport

US Healthcare Cold Chain Logistics Market Temperature Range Outlook

  • Controlled Room Temperature
  • Refrigerated
  • Frozen
  • Cryogenic

Report Scope

MARKET SIZE 20241233.75(USD Million)
MARKET SIZE 20251290.75(USD Million)
MARKET SIZE 20352027.68(USD Million)
COMPOUND ANNUAL GROWTH RATE (CAGR)4.62% (2024 - 2035)
REPORT COVERAGERevenue Forecast, Competitive Landscape, Growth Factors, and Trends
BASE YEAR2024
Market Forecast Period2025 - 2035
Historical Data2019 - 2024
Market Forecast UnitsUSD Million
Key Companies ProfiledThermo Fisher Scientific (US), UPS Healthcare (US), FedEx Healthcare (US), DHL Supply Chain (US), McKesson Corporation (US), Cardinal Health (US), AmerisourceBergen (US), Panalpina (US), Kuehne + Nagel (US)
Segments CoveredApplication, End Use, Temperature Range, Packaging Type, Transport Mode
Key Market OpportunitiesIntegration of advanced tracking technologies enhances efficiency in the US healthcare cold chain logistics market.
Key Market DynamicsRising demand for temperature-sensitive pharmaceuticals drives innovation in US healthcare cold chain logistics solutions.
Countries CoveredUS

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FAQs

What is the expected market size of the US Healthcare Cold Chain Logistics Market in 2024?

The US Healthcare Cold Chain Logistics Market is expected to be valued at 1.2 billion USD in 2024.

What will be the market value of the US Healthcare Cold Chain Logistics Market by 2035?

By 2035, the market is projected to reach 2.2 billion USD.

What is the expected CAGR for the US Healthcare Cold Chain Logistics Market from 2025 to 2035?

The market is expected to grow at a CAGR of 5.665% between 2025 and 2035.

Which mode of delivery is projected to dominate the US Healthcare Cold Chain Logistics Market?

Both Last-Mile Delivery and Hubs-to-Distributor modes are projected to have equal market values at 0.6 billion USD in 2024.

What will be the market value for Last-Mile Delivery in 2035?

The market value for Last-Mile Delivery is anticipated to reach 1.1 billion USD by 2035.

What will be the projected market size for Hubs-to-Distributor by 2035?

The Hubs-to-Distributor mode is expected to achieve a market value of 1.1 billion USD by 2035.

Who are the major players in the US Healthcare Cold Chain Logistics Market?

Key players include Panalpina, Kuehne + Nagel, AmerisourceBergen, and Cardinal Health among others.

What growth opportunities exist in the US Healthcare Cold Chain Logistics Market?

Emerging trends and advancements in technology present significant growth opportunities in the market.

How has the global scenario impacted the US Healthcare Cold Chain Logistics Market?

Current global circumstances and logistical challenges continue to influence functions within the market.

What is the market size for the US Healthcare Cold Chain Logistics Market in 2024 by specific modes of delivery?

Both Last-Mile Delivery and Hubs-to-Distributor modes are valued at 0.6 billion USD in 2024.

How much is the US Healthcare Cold Chain Logistics Market projected to grow by 2035?

By 2035, the market is projected to grow to 2.85 billion USD.

What is the expected compound annual growth rate (CAGR) for the US Healthcare Cold Chain Logistics Market from 2025 to 2035?

The US Healthcare Cold Chain Logistics Market is expected to have a CAGR of 8.581 percent from 2025 to 2035.

Which mode of delivery has a significant market value in the US Healthcare Cold Chain Logistics Market for 2024?

Last-Mile Delivery is valued at 0.57 billion USD in 2024.

What is the market size for the Hubs-to-Distributor segment in 2024?

The Hubs-to-Distributor segment is valued at 0.58 billion USD in 2024.

What will be the market size for Last-Mile Delivery by 2035?

The market size for Last-Mile Delivery is projected to reach 1.39 billion USD by 2035.

How much will the Hubs-to-Distributor segment be worth by 2035?

By 2035, the Hubs-to-Distributor segment is expected to be valued at 1.46 billion USD.

Can you name some key players in the US Healthcare Cold Chain Logistics Market?

Key players include DHL Supply Chain, FedEx, UPS Healthcare, and Cardinal Health.

What are some emerging trends in the US Healthcare Cold Chain Logistics Market?

Emerging trends include increased demand for temperature-sensitive deliveries and advanced tracking technologies.

What challenges does the US Healthcare Cold Chain Logistics Market face?

Challenges include regulatory compliance and the rising cost of specialized logistics solutions.

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