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US Opioid Withdrawal Treatment Market

ID: MRFR/HC/16106-HCR
100 Pages
Garvit Vyas
October 2025

US Opioid Withdrawal Treatment Market Research Report By Treatment Type (Medications, Therapeutic Procedures, Psychological Counseling, Support Groups), By Route of Administration (Oral, Injectable, Transdermal, Nasal), By Patient Type (Inpatient, Outpatient, Emergency) and By Age Group (Children, Adolescents, Adults, Elderly) - Forecast to 2035

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US Opioid Withdrawal Treatment Market Infographic
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US Opioid Withdrawal Treatment Market Summary

As per analysis, the US opioid withdrawal-treatment market size was estimated at 675.69 USD Million in 2024. The US opioid withdrawal-treatment market is projected to grow from 710.49 USD Million in 2025 to 1173.96 USD Million by 2035, exhibiting a compound annual growth rate (CAGR) of 5.15% during the forecast period 2025 - 2035.

Key Market Trends & Highlights

The US opioid withdrawal-treatment market is evolving towards innovative and holistic approaches to address addiction.

  • The rise of non-opioid therapies is reshaping treatment paradigms, appealing to a broader patient base.
  • Integration of technology in treatment, such as telehealth and mobile apps, enhances patient engagement and monitoring.
  • A focus on holistic approaches is gaining traction, emphasizing mental health alongside physical recovery.
  • Key market drivers include increasing awareness of opioid addiction and government initiatives and funding aimed at combating the crisis.

Market Size & Forecast

2024 Market Size 675.69 (USD Million)
2035 Market Size 1173.96 (USD Million)

Major Players

Indivior PLC (GB), Mylan N.V. (US), Teva Pharmaceutical Industries Ltd. (IL), Alkermes PLC (IE), Purdue Pharma L.P. (US), Horizon Therapeutics PLC (IE), NantKwest Inc. (US), Camurus AB (SE)

US Opioid Withdrawal Treatment Market Trends

the opioid withdrawal-treatment market is experiencing notable shifts driven by various factors. Increased awareness of opioid addiction and its consequences has led to a growing demand for effective treatment options. Healthcare providers are increasingly recognizing the importance of addressing withdrawal symptoms, which can be severe and debilitating. This recognition is fostering the development of innovative therapies and support systems aimed at improving patient outcomes. Furthermore, the integration of technology in treatment approaches, such as telemedicine and mobile health applications, is enhancing accessibility and convenience for patients seeking help. In addition, regulatory changes are influencing the landscape of the opioid withdrawal-treatment market. Policies aimed at reducing opioid prescriptions and promoting alternative therapies are gaining traction. This shift is encouraging the exploration of non-opioid medications and holistic approaches to treatment. As a result, the market is likely to see a diversification of available options, catering to a broader range of patient needs. Overall, the opioid withdrawal-treatment market is poised for growth, driven by a combination of increased awareness, technological advancements, and evolving regulatory frameworks.

Rise of Non-Opioid Therapies

There is a noticeable trend towards the development and adoption of non-opioid therapies in the opioid withdrawal-treatment market. This shift is largely motivated by the need to mitigate the risks associated with opioid use, including dependency and overdose. Healthcare providers are increasingly exploring alternative medications and treatment modalities that can effectively manage withdrawal symptoms without the adverse effects linked to opioids.

Integration of Technology in Treatment

The incorporation of technology into treatment strategies is becoming more prevalent in the opioid withdrawal-treatment market. Telehealth services and mobile applications are facilitating remote consultations and support, making it easier for patients to access care. This trend not only enhances patient engagement but also allows for continuous monitoring and personalized treatment plans, which may improve overall outcomes.

Focus on Holistic Approaches

There is a growing emphasis on holistic approaches within the opioid withdrawal-treatment market. This trend reflects a broader understanding of addiction as a complex issue that requires comprehensive care. Integrating psychological support, lifestyle changes, and community resources into treatment plans is becoming more common, as these elements are recognized as vital for long-term recovery.

US Opioid Withdrawal Treatment Market Drivers

Increased Focus on Mental Health

The growing recognition of the link between mental health and substance use disorders is influencing the opioid withdrawal-treatment market. Mental health issues often co-occur with opioid addiction, necessitating integrated treatment approaches. As healthcare providers increasingly adopt holistic models that address both mental health and addiction, the demand for comprehensive withdrawal treatments is likely to rise. This shift in focus is supported by research indicating that individuals with co-occurring disorders benefit from integrated care. Consequently, the opioid withdrawal-treatment market is poised for growth as more providers implement strategies that encompass both mental health and addiction treatment.

Government Initiatives and Funding

Government initiatives aimed at combating the opioid crisis are playing a crucial role in shaping the opioid withdrawal-treatment market. Federal and state governments have allocated substantial funding to support treatment programs and research into effective therapies. For instance, the 21st Century Cures Act has provided billions in funding for mental health and substance use disorder treatment. This financial support is essential for developing new treatment modalities and expanding access to existing therapies. As these initiatives continue to evolve, they are expected to bolster the opioid withdrawal-treatment market, ensuring that more individuals receive the necessary care and support.

Advancements in Treatment Modalities

Innovations in treatment modalities are transforming the opioid withdrawal-treatment market. New pharmacological approaches, such as the development of non-opioid medications and combination therapies, are emerging as effective alternatives for managing withdrawal symptoms. Research indicates that medications like buprenorphine and naltrexone are gaining traction, providing patients with safer options. Additionally, behavioral therapies are being integrated into treatment plans, enhancing overall effectiveness. As these advancements continue to unfold, they are expected to attract more individuals seeking treatment, thereby contributing to the growth of the opioid withdrawal-treatment market.

Increasing Awareness of Opioid Addiction

The opioid withdrawal-treatment market is experiencing growth due to heightened awareness surrounding opioid addiction. Public health campaigns and educational initiatives have significantly increased understanding of the risks associated with opioid use. This awareness has led to a greater demand for treatment options, as individuals seek help for withdrawal symptoms. According to the Substance Abuse and Mental Health Services Administration, approximately 2 million individuals in the US suffer from opioid use disorder, highlighting the urgent need for effective treatment solutions. As awareness continues to rise, the opioid withdrawal-treatment market is likely to expand, with more individuals seeking assistance and healthcare providers responding to this demand.

Rising Incidence of Opioid Overdose Deaths

The alarming rise in opioid overdose deaths is a significant driver of the opioid withdrawal-treatment market. Data from the Centers for Disease Control and Prevention indicates that opioid overdoses have surged, with over 70,000 deaths reported in a single year. This crisis has prompted urgent calls for effective withdrawal treatments, as families and communities seek solutions to mitigate the devastating impact of addiction. The increasing mortality rates associated with opioid use disorder are likely to drive demand for comprehensive treatment options, thereby expanding the opioid withdrawal-treatment market as stakeholders respond to this pressing public health issue.

Market Segment Insights

By Treatment Type: Medications (Largest) vs. Therapeutic Procedures (Fastest-Growing)

In the US opioid withdrawal-treatment market, the medications segment holds the largest market share, being favored due to their effectiveness in managing withdrawal symptoms. This segment encompasses various pharmacological options, including methadone, buprenorphine, and naltrexone, which are critical in helping individuals cope with opioid dependence. Conversely, therapeutic procedures, while currently smaller in market share, are rapidly gaining traction as alternative treatment approaches, offering innovative solutions that enhance patient care and recovery outcomes. The growth trends within this segment are driven by increasing awareness of opioid addiction, evolving treatment paradigms, and an emphasis on patient-centered care. The surging interest in holistic treatment options is propelling psychological counseling and support groups to emerge as essential components of recovery, aligning well with contemporary perspectives that value comprehensive and multi-faceted treatment approaches. This growth is further supported by state initiatives and federal funding aimed at combating the opioid crisis, leading to increased adoption of varied treatment modalities.

Medications: Dominant vs. Psychological Counseling: Emerging

Medications, as the dominant treatment type in the US opioid withdrawal-treatment market, provide essential support to patients during the challenging withdrawal phase. Their effectiveness in alleviating cravings and physical symptoms positions them as a cornerstone of treatment protocols. On the other hand, psychological counseling serves as an emerging treatment type that focuses on addressing the underlying psychological factors contributing to addiction. This integrative approach is gaining significance as awareness grows about the necessity of mental health support in recovery. By combining medication management with psychological counseling, treatment providers aim to enhance recovery rates, reduce the likelihood of relapse, and foster a supportive environment for individuals seeking to overcome opioid dependence.

By Route of Administration: Oral (Largest) vs. Injectable (Fastest-Growing)

In the US opioid withdrawal-treatment market, the route of administration segment showcases distinct preferences among healthcare professionals and patients alike. Oral administration is the most widely adopted method, capturing the largest share of the market due to its convenience and compliance advantages. Injectable and transdermal routes also play significant roles, yet they hold a smaller market share compared to the oral segment. On the other hand, nasal administration is gradually gaining traction, though still minor in the overall distribution. Growth trends in this segment reveal a shift towards non-invasive treatment methods, particularly the rising preference for oral solutions. This shift is driven by an increasing emphasis on patient comfort and adherence to treatment protocols. The injectable route is emerging as the fastest-growing segment due to its efficacy in acute withdrawal management, prompting innovation and new product development to cater to this demand. Furthermore, healthcare systems are actively shifting resources towards more effective and patient-friendly options, thus influencing the growth of these routes.

Oral (Dominant) vs. Injectable (Emerging)

Oral administration remains the dominant route in the US opioid withdrawal-treatment market, driven by its ease of use, patient acceptability, and consistent dosing. Patients are more likely to adhere to treatment regimens that involve oral medications, resulting in improved recovery outcomes. Despite this dominance, injectable administration is quickly emerging, particularly for patients requiring rapid intervention during acute withdrawal episodes. The injectable forms, such as naloxone, offer rapid action and are vital for emergency situations. However, their requirement for skilled healthcare professionals for administration can limit their broader application. This dynamic between oral and injectable methods highlights the market's ongoing evolution and the necessity for diverse treatment options tailored to patient needs.

By Patient Type: Inpatient (Largest) vs. Outpatient (Fastest-Growing)

In the US opioid withdrawal-treatment market, the distribution of patient types reveals a significant predominance of inpatient care, which captures the largest share. This segment is favored due to the comprehensive support and monitoring it offers, benefiting patients with severe withdrawal symptoms. On the other hand, outpatient care has carved out a substantial niche, preferred by many due to cost-effectiveness and flexibility. Emergency treatments also play a crucial role, particularly in acute situations, although they represent a smaller portion of the overall treatment landscape. Recent growth trends highlight outpatient care as the fastest-growing segment, driven by increasing healthcare accessibility and the rising number of treatment programs emphasizing convenience. There is a notable shift towards integrating telemedicine and outpatient services, allowing for more personalized care and engagement. Additionally, a growing public awareness of opioid addiction and recovery options is fostering greater participation in outpatient programs, further accelerating this trend.

Inpatient: Dominant vs. Outpatient: Emerging

The inpatient segment is characterized by its structured, intensive treatment approach, crucial for managing the complexities of opioid withdrawal. Its dominance stems from the ability to provide 24/7 medical support, ensuring immediate intervention in case of severe withdrawal symptoms. Conversely, outpatient treatment is emerging as a viable alternative, attracting those seeking more flexible options that fit into their daily lives. This segment is particularly appealing to patients who have support networks at home and prefer to avoid the stigma associated with inpatient care. As healthcare systems adapt to the evolving needs of patients, both segments are likely to coexist, offering complementary benefits.

By Age Group: Adults (Largest) vs. Adolescents (Fastest-Growing)

In the US opioid withdrawal-treatment market, the age group of adults dominates, commanding a significant share compared to other segments, including children, adolescents, and the elderly. The prevalence of opioid-related issues in adults has historically placed this demographic at the forefront of treatment initiatives, resulting in consistently high market demand. Conversely, the adolescent segment is emerging as the fastest-growing demographic within this market. Increased awareness of opioid addiction among teens and rising treatment initiatives tailored for this age group drive its rapid expansion. This trend is further supported by educational programs and social campaigns aimed at prevention and rehabilitation, fostering a supportive environment for adolescent recovery efforts.

Adults (Dominant) vs. Adolescents (Emerging)

The adult demographic in the US opioid withdrawal-treatment market is characterized by a broad range of service needs and a variety of treatment options, from detoxification and counseling to medication-assisted treatments. This group often benefits from a diverse approach to treatment that includes both inpatient and outpatient services, reflecting the complex nature of opioid addiction. Meanwhile, the adolescent segment is gaining prominence; rapid growth in this group prompts new treatment methodologies tailored to younger patients. These methodologies include peer support programs and adapted therapeutic practices that resonate with younger audiences. As treatment resources become more youth-centric, this segment is expected to continue its upward trajectory in the market.

Get more detailed insights about US Opioid Withdrawal Treatment Market

Key Players and Competitive Insights

the opioid withdrawal-treatment market characterizes a complex competitive landscape, driven by increasing demand for effective treatment options and a growing awareness of opioid addiction's societal impact. Key players such as Indivior PLC (GB), Mylan N.V. (US), and Teva Pharmaceutical Industries Ltd. (IL) are actively shaping this environment through various strategic initiatives. Indivior PLC (GB) focuses on innovation in drug formulations, particularly with its buprenorphine-based products, which are designed to enhance patient adherence and reduce withdrawal symptoms. Meanwhile, Mylan N.V. (US) emphasizes regional expansion and partnerships to broaden its market reach, particularly in underserved areas. Teva Pharmaceutical Industries Ltd. (IL) is leveraging its extensive generics portfolio to provide cost-effective alternatives, thereby positioning itself as a leader in affordability within the market.

The business tactics employed by these companies include localizing manufacturing and optimizing supply chains to enhance efficiency and responsiveness to market demands. The market structure appears moderately fragmented, with several players competing for market share while also collaborating on initiatives aimed at improving treatment accessibility. This collective influence of key players fosters a dynamic environment where innovation and strategic partnerships are paramount.

In October 2025, Indivior PLC (GB) announced a collaboration with a leading telehealth provider to integrate digital health solutions into its treatment offerings. This strategic move is likely to enhance patient engagement and facilitate remote monitoring, thereby improving treatment outcomes. Such integration of technology into traditional treatment paradigms reflects a broader trend towards digitalization in healthcare.

In September 2025, Mylan N.V. (US) launched a new formulation of its buprenorphine product, which is designed to provide a more stable release profile. This innovation is expected to address patient needs more effectively and may lead to increased market penetration. The introduction of this product underscores Mylan's commitment to enhancing treatment efficacy and patient satisfaction.

In August 2025, Teva Pharmaceutical Industries Ltd. (IL) expanded its distribution network by partnering with community health organizations across the US. This initiative aims to improve access to opioid withdrawal treatments in rural and underserved areas, thereby addressing a critical gap in the market. Such strategic alliances not only enhance Teva's market presence but also contribute to broader public health goals.

As of November 2025, current competitive trends in the opioid withdrawal-treatment market include a pronounced shift towards digitalization, sustainability, and the integration of artificial intelligence in treatment protocols. Strategic alliances are increasingly shaping the landscape, enabling companies to pool resources and expertise. Looking ahead, competitive differentiation is likely to evolve from traditional price-based competition to a focus on innovation, technology integration, and supply chain reliability, reflecting a more sophisticated approach to addressing the complexities of opioid addiction.

Key Companies in the US Opioid Withdrawal Treatment Market market include

Industry Developments

The US Opioid Withdrawal Treatment Market has been witnessing significant developments recently, particularly as the demand for effective treatment options continues to grow amid the opioid crisis. As of October 2023, companies like Indivior and Alkermes are advancing therapeutic solutions, with Indivior focusing on innovative formulations for opioid addiction treatment. RiverMend Health has also expanded its services to provide comprehensive care for individuals dealing with substance use disorders.

Notably, in March 2023, Purdue Pharma announced a settlement on its bankruptcy plan, aiming to direct funds toward addiction treatment initiatives, which reflects a shift in corporate responsibility amid ongoing litigation related to the opioid epidemic. Moreover, Zynerba Pharmaceuticals is making strides in cannabinoid-based therapies, enhancing the scope of treatment methods available. In terms of mergers and acquisitions, in April 2023, Appian Health announced a strategic acquisition to bolster its treatment infrastructure. The market valuation continues to rise as legislative changes support increased funding for addiction treatment services, driving growth for key players like Braeburn Pharmaceuticals and Thermo Fisher Scientific.

Over the past two years, the focus on integrated treatment approaches has gained momentum, allowing companies to play a more pivotal role in combating opioid dependence in the US.

Future Outlook

US Opioid Withdrawal Treatment Market Future Outlook

The opioid withdrawal-treatment market is projected to grow at 5.15% CAGR from 2024 to 2035, driven by increasing demand for effective treatment options and innovative therapies.

New opportunities lie in:

  • Development of telehealth platforms for remote patient monitoring
  • Integration of AI-driven analytics for personalized treatment plans
  • Expansion of partnerships with pharmacies for medication-assisted treatment access

By 2035, the market is expected to achieve substantial growth and enhanced treatment accessibility.

Market Segmentation

US Opioid Withdrawal Treatment Market Age Group Outlook

  • Children
  • Adolescents
  • Adults
  • Elderly

US Opioid Withdrawal Treatment Market Patient Type Outlook

  • Inpatient
  • Outpatient
  • Emergency

US Opioid Withdrawal Treatment Market Treatment Type Outlook

  • Medications
  • Therapeutic Procedures
  • Psychological Counseling
  • Support Groups

US Opioid Withdrawal Treatment Market Route of Administration Outlook

  • Oral
  • Injectable
  • Transdermal
  • Nasal

Report Scope

MARKET SIZE 2024 675.69(USD Million)
MARKET SIZE 2025 710.49(USD Million)
MARKET SIZE 2035 1173.96(USD Million)
COMPOUND ANNUAL GROWTH RATE (CAGR) 5.15% (2024 - 2035)
REPORT COVERAGE Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
BASE YEAR 2024
Market Forecast Period 2025 - 2035
Historical Data 2019 - 2024
Market Forecast Units USD Million
Key Companies Profiled Indivior PLC (GB), Mylan N.V. (US), Teva Pharmaceutical Industries Ltd. (IL), Alkermes PLC (IE), Purdue Pharma L.P. (US), Horizon Therapeutics PLC (IE), NantKwest Inc. (US), Camurus AB (SE)
Segments Covered Treatment Type, Route of Administration, Patient Type, Age Group
Key Market Opportunities Integration of digital therapeutics and telehealth solutions enhances access to opioid withdrawal-treatment.
Key Market Dynamics Rising demand for innovative therapies drives competition and regulatory scrutiny in the opioid withdrawal-treatment market.
Countries Covered US

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FAQs

What is the expected market size of the US Opioid Withdrawal Treatment Market in 2024?

The US Opioid Withdrawal Treatment Market is expected to be valued at 750.0 USD Million in 2024.

What will be the market size of the US Opioid Withdrawal Treatment Market by 2035?

By 2035, the market is projected to grow to 1300.0 USD Million.

What is the expected CAGR for the US Opioid Withdrawal Treatment Market from 2025 to 2035?

The expected CAGR for the market during this period is 5.128 %.

Which treatment type holds the largest market value in 2024?

In 2024, the Medications segment is anticipated to hold the largest market value at 300.0 USD Million.

What will be the market value of Therapeutic Procedures by 2035?

The market value for Therapeutic Procedures is expected to reach 300.0 USD Million by 2035.

Who are the key players in the US Opioid Withdrawal Treatment Market?

Key players include Psychemedics, RiverMend Health, Alkermes, and Indivior among others.

What is the projected market value for Support Groups by 2035?

The market value for Support Groups is expected to increase to 250.0 USD Million by 2035.

What are the expected growth drivers for the US Opioid Withdrawal Treatment Market?

Growth drivers include an increase in opioid addiction cases and advancements in treatment methodologies.

How much will the Psychological Counseling segment be valued at in 2024?

The Psychological Counseling segment is expected to be valued at 150.0 USD Million in 2024.

What trends are emerging in the US Opioid Withdrawal Treatment Market?

Emerging trends include a rise in digital therapeutic solutions and a focus on holistic treatment approaches.

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