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    Nucleic Acid-based Therapeutics Market

    ID: MRFR/Pharma/2192-HCR
    200 Pages
    Rahul Gotadki
    October 2025

    Nucleic Acid-Based Therapeutics Market Research Report By Therapeutic Type (Antisense Oligonucleotides, RNA Interference, Gene Therapy, CRISPR, DNA Vaccines), By Application (Oncology, Genetic Disorders, Infectious Diseases, Cardiovascular Diseases), By Route of Administration (Injectable, Oral, Topical), By End User (Hospitals, Research Institutions, Pharmaceutical Companies, Biotechnology Companies) and By Regional (North America, Europe, South America, Asia Pacific, Middle East and Africa)- Forecast to 2035

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    Nucleic Acid-based Therapeutics Market Summary

    As per Market Research Future analysis, the Nucleic Acid-Based Therapeutics Market was valued at 0.62 USD Billion in 2024 and is projected to grow to 0.97 USD Billion by 2035, reflecting a CAGR of 4.12% from 2025 to 2035. The market is driven by the increasing prevalence of genetic disorders, advancements in mRNA technology, and a growing demand for precision medicine. Regulatory support is enhancing the development of nucleic acid therapies, while collaborations between academia and industry are translating research into therapeutic solutions.

    Key Market Trends & Highlights

    The Nucleic Acid-Based Therapeutics Market is witnessing transformative trends.

    • Market size in 2024 is expected to reach 9.63 USD Billion.
    • Antisense Oligonucleotides are projected to grow from 2.38 USD Billion in 2024 to 6.18 USD Billion by 2035.
    • Gene Therapy is anticipated to increase from 3.25 USD Billion in 2024 to 8.5 USD Billion by 2035.
    • North America is expected to dominate the market with a valuation of 4.12 USD Billion in 2024.

    Market Size & Forecast

    2024 Market Size USD 0.62 Billion
    2035 Market Size USD 0.97 Billion
    CAGR (2025-2035) 4.12%

    Major Players

    Key players include Vertex Pharmaceuticals, Pfizer, Ionis Pharmaceuticals, Moderna, and Novartis.

    Nucleic Acid-based Therapeutics Market Trends

    The Nucleic Acid-Based Therapeutics Market is experiencing rapid growth and so investment spending due to the emergence of genomic medicine alongside the growing propensity for biotechnological genetic disorders. The growth of personalized medicine is indeed significant, focused on treatment through nucleic acid-based techniques and the development of tailored therapies. 

    Moreover, the R&D in mRNA technologies during the COVID-19 pandemic created new opportunities for therapeutics and vaccine development, innovative approaches for many other diseases are being sought.

    A broader opportunity that poses a challenge in the dynamic market is the application of artificial intelligence and machine learning to the processes of drug discovery. Such a development provides a chance to improve the design and optimization of nucleic acid-based therapies. 

    Furthermore, new economies are now starting to devote more of their budgets to the funding of sophisticated therapeutics, thus, providing fertile ground to industry stakeholders who wish to widen their market coverage. Recently observed trends are the increased collaboration between academic institutions and industries, enabling the conversion of research results into authentic therapy solutions.

    Worldwide, regulatory bodies are responding to the dynamic changes of innovations in a more positive manner towards the authorization of products based on nucleic acids. The focus on supporting clinical trial works and providing favorable conditions for work in gene therapies indicate that there is a positive attitude toward these advanced treatment options. In summary, the global turn to therapies based on nucleic acids is moving on to more sophisticated approaches to heal complex health problems using engineering at the molecular level.

    The ongoing advancements in nucleic acid-based therapeutics are poised to revolutionize treatment paradigms, offering unprecedented precision in targeting genetic disorders and enhancing patient outcomes.

    U.S. National Institutes of Health (NIH)

    Nucleic Acid-based Therapeutics Market Drivers

    Market Growth Projections

    Rising Prevalence of Genetic Disorders

    The increasing incidence of genetic disorders globally drives the demand for nucleic acid-based therapeutics. Conditions such as cystic fibrosis and muscular dystrophy are becoming more prevalent, necessitating innovative treatment solutions. The Global Nucleic Acid-Based Therapeutics Market Industry is poised to address these challenges, with a projected market value of 9.63 USD Billion in 2024. This growth is indicative of the urgent need for effective therapies that can target the underlying genetic causes of these disorders, thereby improving patient outcomes and quality of life.

    Growing Demand for Personalized Medicine

    The shift towards personalized medicine is significantly influencing the Global Nucleic Acid-Based Therapeutics Market Industry. Tailored therapies that consider individual genetic profiles are gaining traction, as they promise improved efficacy and reduced side effects. This trend is particularly evident in oncology, where nucleic acid-based therapies can be customized to target specific mutations in tumors. The market's growth trajectory, with an expected value of 9.63 USD Billion in 2024, underscores the increasing recognition of personalized approaches in treatment paradigms, aligning with patient-centric healthcare models.

    Advancements in Gene Editing Technologies

    Technological advancements in gene editing, particularly CRISPR and TALEN, are revolutionizing the Global Nucleic Acid-Based Therapeutics Market Industry. These innovations enhance the precision and efficiency of therapeutic interventions, allowing for targeted modifications at the genetic level. As a result, the market is expected to expand significantly, with forecasts suggesting a growth to 25.4 USD Billion by 2035. The ability to edit genes with high specificity opens new avenues for treating a variety of diseases, including cancer and rare genetic conditions, thereby attracting substantial investment and research efforts.

    Regulatory Support for Innovative Therapies

    Regulatory bodies are increasingly supportive of nucleic acid-based therapeutics, facilitating their development and approval processes. Initiatives aimed at expediting the review of innovative therapies are evident in various regions, enhancing the Global Nucleic Acid-Based Therapeutics Market Industry. This supportive regulatory environment encourages companies to invest in research and development, leading to a broader array of treatment options for patients. The anticipated growth to 25.4 USD Billion by 2035 reflects the positive impact of regulatory frameworks that prioritize patient access to groundbreaking therapies.

    Increased Investment in Biopharmaceutical Research

    The surge in investment within the biopharmaceutical sector is a crucial driver for the Global Nucleic Acid-Based Therapeutics Market Industry. Governments and private entities are channeling funds into research and development, fostering innovation in nucleic acid therapies. This financial support is essential for advancing clinical trials and bringing new therapies to market. As a result, the market is anticipated to grow at a CAGR of 9.22% from 2025 to 2035, reflecting the commitment to developing effective nucleic acid-based treatments that can address unmet medical needs.

    Market Segment Insights

    Nucleic Acid-Based Therapeutics Market Therapeutic Type Insights

    The Nucleic Acid-Based Therapeutics Market, approaching a valuation of 9.63 USD Billion in 2024, showcases a dynamic landscape segmented by therapeutic type, reflecting significant potential for further growth. Antisense Oligonucleotides (ASOs) are crucial within this market, holding a valuation of 2.38 USD Billion in 2024, projected to increase to 6.18 USD Billion by 2035, indicating a steady rise in their use for treating genetic disorders and viral infections through targeted action at the mRNA level. 

    Similarly, RNA Interference, valued at 1.54 USD Billion in 2024 and reaching 4.02 USD Billion by 2035, plays a vital role in gene silencing, which is now being recognized for its capacity to address challenging conditions, including cancers and neurodegenerative diseases, thereby providing strong implications for innovative treatments in the healthcare sector.

    In contrast, Gene Therapy commands a larger share, with a valuation expected to grow from 3.25 USD Billion in 2024 to 8.5 USD Billion in 2035. This area has seen remarkable advancements, enabling the treatment of genetic disorders by correcting deranged genes, which resonates with a growing demand for personalized medicine approaches. 

    CRISPR technology, valued at 1.83 USD Billion in 2024 and anticipated to hit 4.75 USD Billion by 2035, stands out for its ability to edit genes with precision, presenting vast opportunities for disease treatment and agricultural enhancements, thus showcasing a significant impact beyond traditional therapy landscapes.

    Lastly, the DNA Vaccines segment, although smaller, valued at 0.63 USD Billion in 2024 and projected to rise to 2.35 USD Billion by 2035, is garnering attention for its potential to stimulate effective immune responses against infectious diseases. Overall, the diverse therapeutic types within the Nucleic Acid-Based Therapeutics Market reveal a robust growth trajectory necessitating increased Research and Development innovations and strategic collaborations to address existing challenges in treatment modalities and enhance patient outcomes.

    Nucleic Acid-Based Therapeutics Market Application Insights

    The Nucleic Acid-Based Therapeutics Market is experiencing significant growth, with its overall market expected to be valued at 9.63 billion USD in 2024 and projected to reach 25.4 billion USD by 2035. This market segmentation captures various critical applications, including Oncology, Genetic Disorders, Infectious Diseases, and Cardiovascular Diseases. Oncology remains a dominant segment, largely due to increasing incidences of cancer and growing acceptance of gene therapies. 

    Genetic Disorders are also significant, driven by advancements in gene editing technologies and rising awareness about rare diseases.Infectious Diseases, particularly with the surge of viral infections and the need for rapid therapeutic interventions, underscore the necessity of nucleic acid-based strategies. Cardiovascular Diseases are gaining attention as innovative treatments emerge, offering new hope for patients. The market's expansion is propelled by rising healthcare expenditures, increased investment in Research and Development, and technological advancements in gene delivery systems. 

    However, challenges such as regulatory hurdles and high development costs pose constraints.Overall, the Nucleic Acid-Based Therapeutics Market statistics reflect a dynamic landscape marked by evolving applications and promising opportunities across its segments.

    Nucleic Acid-Based Therapeutics Market Route of Administration Insights

    The Nucleic Acid-Based Therapeutics Market demonstrates substantial growth in the Route of Administration segment, reflecting an increasing demand for innovative delivery methods that enhance therapeutic efficacy. By 2024, the global market is expected to reach a valuation of 9.63 USD Billion, with the landscape driven by advancements in delivery mechanisms. Injectable methods are vital due to their ability to ensure precise dosage and rapid absorption, making them integral for therapies that require immediate action. 

    Oral formulations are gaining momentum as they offer ease of administration and patient compliance, thus broadening accessibility to nucleic acid-based therapies.The topical route, while smaller, holds significance in localized treatments, allowing targeted delivery without systemic exposure. Trends such as the rise in chronic diseases and advancements in genetic engineering are fueling the Nucleic Acid-Based Therapeutics Market growth. 

    However, challenges related to formulation stability and regulatory hurdles persist. Overall, the market is poised for expansion, supported by ongoing Research and Development efforts directed at refining these routes of administration for improved patient outcomes.

    Nucleic Acid-Based Therapeutics Market End User Insights

    The Nucleic Acid-Based Therapeutics Market is expected to be valued at 9.63 USD Billion in 2024, driven by a diverse range of end users including hospitals, research institutions, pharmaceutical companies, and biotechnology companies. Hospitals play a crucial role in the practicality of these therapeutics, focusing on patient administration and clinical applications.

     Research institutions serve as the backbone of innovation, conducting essential studies and trials that propel the market forward. Pharmaceutical companies are vital, engaging in the development and commercialization of nucleic acid therapeutics, contributing significantly to market dynamics.

    Biotechnology companies, often on the cutting edge, are crucial in enhancing therapeutic approaches through genetic targeting and novel delivery systems. 

    Together, these end users reflect the robust segmentations within the Nucleic Acid-Based Therapeutics Market, illustrating a complex ecosystem that drives growth and facilitates advancements. As the market evolves, it experiences trends toward personalized medicine and continuous R efforts that support long-term growth while facing challenges in regulations and market deployment, creating both opportunities and hurdles for stakeholders.

    Get more detailed insights about Nucleic Acid-based Therapeutics Market Research Report- Forecast to 2035

    Regional Insights

    The Nucleic Acid-Based Therapeutics Market is poised for considerable growth, with North America leading the way. In 2024, North America is valued at 4.12 USD Billion, dominating the market due to advanced healthcare infrastructure and significant investments in Research and Development initiatives. 

    Europe follows as a significant region with a valuation of 2.75 USD Billion in the same year, driven by its robust regulatory framework and increasing adoption of innovative therapies. In the Asia-Pacific (APAC) region, the market is valued at 2.44 USD Billion in 2024, reflecting a strong demand for advanced medical products and governmental support for biopharmaceuticals.

    South America and the Middle East and Africa (MEA) contribute modestly, valued at 0.77 USD Billion and 0.55 USD Billion respectively; these regions present opportunities for future growth as healthcare access improves. Generally, the variation in market values across regions indicates differing levels of market maturity, research capabilities, and healthcare funding, highlighting the need for tailored strategies in the Nucleic Acid-Based Therapeutics Market to harness potential opportunities efficiently.

    Nucleic Acid-based Therapeutics Market Region

    Key Players and Competitive Insights

    The Nucleic Acid-Based Therapeutics Market is characterized by a dynamic landscape driven by rapid advancements in biotechnology and genomics. This market encompasses a broad range of therapeutic applications, including gene therapy, RNA-based therapies, and other nucleic acid modalities designed to address various diseases, particularly genetic disorders and cancers. 

    Competitive insights into this market reveal that key players are heavily investing in research and development to create innovative treatments, and they are also forming strategic partnerships and collaborations to strengthen their portfolios. 

    Additionally, regulatory approvals play a significant role in the competitive dynamics, as companies strive to navigate the complexities of bringing nucleic acid therapeutics to market effectively. The presence of several biotech firms alongside established pharmaceutical giants contributes to a highly competitive environment, ensuring that advancements continue to emerge rapidly.

    Vertex Pharmaceuticals holds a significant position in the Nucleic Acid-Based Therapeutics Market, showcasing its strengths through a strong focus on rare diseases and genetic disorders. The company's commitment to innovation is evident in its investment in research and development specifically targeting cystic fibrosis, while also exploring nucleic acid-based approaches for future therapies. 

    Vertex Pharmaceuticals has developed specialized expertise and created a network of collaborations that bolster its presence in the market. The company benefits from a robust intellectual property portfolio that protects its advancements and reinforces its competitive edge. This approach underscores Vertex Pharmaceuticals’ strategy of leveraging its scientific capabilities and strategic alliances to drive success in the rapidly evolving nucleic acid therapeutics landscape.

    Pfizer is a formidable player in the Nucleic Acid-Based Therapeutics Market, leveraging its extensive experience in biotechnology and a strong infrastructure to support the development and commercialization of innovative therapies. The company's robust pipeline includes multiple nucleic acid-based products, with a keen focus on RNA-based therapeutics and gene editing technologies. Key strengths of Pfizer include its vast global reach, established partnerships with academic and research institutions, and a history of successful mergers and acquisitions that have expanded its capabilities in the nucleic acid therapeutics domain. 

    The company’s commitment to advancing genetic medicine is highlighted by its efforts to bring novel therapies to patients as efficiently as possible. Through its continuous investment in RD and emphasis on collaboration, Pfizer is well-positioned to advance its offerings in the Nucleic Acid-Based Therapeutics Market significantly.

    Key Companies in the Nucleic Acid-based Therapeutics Market market include

    Industry Developments

    • Q2 2024: Switch Therapeutics Announces $52 Million Series B Financing to Advance RNAi Therapeutics Pipeline Switch Therapeutics, a biotechnology company developing RNAi-based therapeutics, announced the closing of a $52 million Series B financing round to support the advancement of its pipeline and platform technologies.
    • Q2 2024: TransCode Therapeutics Receives FDA Orphan Drug Designation for TTX-MC138 for the Treatment of Pancreatic Cancer TransCode Therapeutics announced that the U.S. FDA has granted Orphan Drug Designation to its lead candidate, TTX-MC138, an RNA-based therapeutic, for the treatment of pancreatic cancer.
    • Q1 2024: Avidity Biosciences Announces FDA Clearance of IND for AOC 1044 for the Treatment of Duchenne Muscular Dystrophy Avidity Biosciences received FDA clearance of its Investigational New Drug (IND) application for AOC 1044, an oligonucleotide-based therapy for Duchenne Muscular Dystrophy, enabling the initiation of clinical trials.
    • Q2 2024: Moderna, Immatics Announce Strategic Research and Development Collaboration to Develop Novel mRNA-based Cancer Therapies Moderna and Immatics entered into a multi-year strategic collaboration to jointly develop mRNA-based cancer immunotherapies, combining Moderna’s mRNA technology with Immatics’ TCR platform.
    • Q1 2024: Silence Therapeutics Announces FDA Fast Track Designation for SLN124 in Polycythemia Vera Silence Therapeutics received FDA Fast Track Designation for SLN124, a small interfering RNA (siRNA) therapeutic, for the treatment of polycythemia vera.
    • Q2 2024: Otsuka and Shape Therapeutics Announce Strategic Collaboration to Develop RNA Technologies for CNS Disorders Otsuka Pharmaceutical and Shape Therapeutics announced a strategic collaboration to develop and commercialize RNA-based therapeutics for central nervous system (CNS) disorders.
    • Q1 2024: Alnylam Pharmaceuticals Announces FDA Approval of AMVUTTRA (vutrisiran) for the Treatment of Hereditary Transthyretin-Mediated Amyloidosis Alnylam Pharmaceuticals received FDA approval for AMVUTTRA (vutrisiran), an RNAi therapeutic for the treatment of hereditary transthyretin-mediated amyloidosis.
    • Q2 2024: Arrowhead Pharmaceuticals and Horizon Therapeutics Announce Collaboration to Develop RNAi Therapeutics for Gout Arrowhead Pharmaceuticals and Horizon Therapeutics entered into a collaboration agreement to develop RNA interference (RNAi) therapeutics targeting gout.
    • Q1 2024: Stoke Therapeutics Announces $125 Million Public Offering of Common Stock Stoke Therapeutics, focused on RNA-based medicines, announced the closing of a $125 million public offering to fund the advancement of its clinical and preclinical programs.
    • Q2 2024: Wave Life Sciences Announces FDA Clearance of IND for WVE-006 for Alpha-1 Antitrypsin Deficiency Wave Life Sciences received FDA clearance of its IND application for WVE-006, an RNA editing therapeutic for the treatment of alpha-1 antitrypsin deficiency.
    • Q1 2024: Ionis Pharmaceuticals Appoints Dr. Brett Monia as Chief Executive Officer Ionis Pharmaceuticals, a leader in RNA-targeted therapeutics, announced the appointment of Dr. Brett Monia as Chief Executive Officer.
    • Q2 2024: Pfizer and Beam Therapeutics Announce Collaboration to Develop In Vivo Base Editing Programs for Rare Diseases Pfizer and Beam Therapeutics announced a collaboration to develop in vivo base editing programs, leveraging nucleic acid-based technologies to target rare genetic diseases.

    Future Outlook

    Nucleic Acid-based Therapeutics Market Future Outlook

    The Nucleic Acid-Based Therapeutics Market is projected to grow at a 4.12% CAGR from 2025 to 2035, driven by advancements in gene editing, increasing prevalence of genetic disorders, and rising investment in biopharmaceuticals.

    New opportunities lie in:

    • Develop personalized mRNA therapies targeting rare diseases.
    • Invest in CRISPR technology for precision gene editing solutions.
    • Expand partnerships with biotech firms for innovative delivery systems.

    By 2035, the market is expected to achieve substantial growth, solidifying its position as a leader in therapeutic innovation.

    Market Segmentation

    Nucleic Acid-Based Therapeutics Market End User Outlook

    • Hospitals
    • Research Institutions
    • Pharmaceutical Companies
    • Biotechnology Companies

    Nucleic Acid-Based Therapeutics Market Regional Outlook

    • North America
    • Europe
    • South America
    • Asia Pacific
    • Middle East and Africa

    Nucleic Acid-Based Therapeutics Market Application Outlook

    • Oncology
    • Genetic Disorders
    • Infectious Diseases
    • Cardiovascular Diseases

    Nucleic Acid-Based Therapeutics Market Therapeutic Type Outlook

    • Antisense Oligonucleotides
    • RNA Interference
    • Gene Therapy
    • CRISPR
    • DNA Vaccines

    Nucleic Acid-Based Therapeutics Market Route of Administration Outlook

    • Injectable
    • Oral
    • Topical

    Report Scope

    Report Attribute/Metric Source: Details
    MARKET SIZE 2023 8.82(USD Billion)
    MARKET SIZE 2024 9.63(USD Billion)
    MARKET SIZE 2035 25.4(USD Billion)
    COMPOUND ANNUAL GROWTH RATE (CAGR) 4.12% (2025 - 2035)
    REPORT COVERAGE Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
    BASE YEAR 2024
    MARKET FORECAST PERIOD 2025 - 2035
    HISTORICAL DATA 2019 - 2023
    MARKET FORECAST UNITS USD Billion
    KEY COMPANIES PROFILED Vertex Pharmaceuticals, Pfizer, Ionis Pharmaceuticals, Astera Institute, Roche, GSK, Sangamo Therapeutics, Novartis, Regeneron Pharmaceuticals, Exelixis, Bayer, Moderna, Dicerna Pharmaceuticals, Amgen, Sanofi
    SEGMENTS COVERED Therapeutic Type, Application, Route of Administration, End User, Regional
    KEY MARKET OPPORTUNITIES Increased R&D funding, Rising prevalence of genetic disorders, Advancements in delivery technologies, Growing demand for personalized medicine, Expanding applications in oncology
    KEY MARKET DYNAMICS Increasing prevalence of genetic disorders, Advancements in gene editing technologies, Growing investment in R&D, Rising demand for personalized medicine, Expanding applications in oncology
    COUNTRIES COVERED North America, Europe, APAC, South America, MEA
    Market Size 2024 0.62
    Market Size 2025 0.65
    Market Size 2035 0.97
    Base Year 2024
    Market Forecast Period 2025 - 2035

    Market Highlights

    Author
    Rahul Gotadki
    Assistant Manager

    He holds an experience of about 7+ years in Market Research and Business Consulting, working under the spectrum of Life Sciences and Healthcare domains. Rahul conceptualizes and implements a scalable business strategy and provides strategic leadership to the clients. His expertise lies in market estimation, competitive intelligence, pipeline analysis, customer assessment, etc. In addition to the above, his other responsibility includes strategic tracking of high growth markets & advising clients on the potential areas of focus they could direct their business initiatives

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    FAQs

    What is the expected market size of the Global Nucleic Acid-Based Therapeutics Market in 2024?

    The Global Nucleic Acid-Based Therapeutics Market is expected to be valued at 9.63 USD Billion in 2024.

    What will be the market value projected for the Global Nucleic Acid-Based Therapeutics Market by 2035?

    By 2035, the Global Nucleic Acid-Based Therapeutics Market is projected to reach approximately 25.4 USD Billion.

    What is the expected compound annual growth rate (CAGR) for the Global Nucleic Acid-Based Therapeutics Market from 2025 to 2035?

    The expected CAGR for the Global Nucleic Acid-Based Therapeutics Market from 2025 to 2035 is 9.21%.

    Which region is anticipated to have the largest market share in the Global Nucleic Acid-Based Therapeutics Market by 2024?

    North America is anticipated to hold the largest market share with a value of 4.12 USD Billion in 2024.

    How much is the Nucleic Acid-Based Therapeutics Market expected to be valued in Europe by 2035?

    The Nucleic Acid-Based Therapeutics Market in Europe is expected to be valued at 7.3 USD Billion by 2035.

    What are the projected values for Antisense Oligonucleotides by 2035?

    Antisense Oligonucleotides are projected to be valued at 6.18 USD Billion by 2035.

    Which key players are leading the Global Nucleic Acid-Based Therapeutics Market?

    Key players in the market include Vertex Pharmaceuticals, Pfizer, and Roche among others.

    What is the forecasted market size for Gene Therapy in 2024?

    The market size for Gene Therapy is forecasted to be 3.25 USD Billion in 2024.

    How much market growth is expected in the APAC region by 2035?

    The APAC region is expected to reach a market value of 6.5 USD Billion by 2035.

    What is the expected market size for CRISPR technology by 2024?

    The expected market size for CRISPR technology is 1.83 USD Billion by 2024.

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