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    Oligonucleotide Synthesis Market

    ID: MRFR/LS/1721-HCR
    200 Pages
    Rahul Gotadki
    October 2025

    Oligonucleotide Synthesis Market Research Report By Product Type (DNA Oligonucleotides, RNA Oligonucleotides, Modified Oligonucleotides, ASO Oligonucleotides), By Application (Diagnostics, Therapeutics, Research Development, Gene Synthesis), By End User (Pharmaceutical Companies, Biotechnology Companies, Academic Research Institutions, Contract Research Organizations), By Technology (Solid-Phase Synthesis, Liquid-Phase Synthesis, Microarray Technology) and By Regional (North America, Europe, South America, Asia Pacific, Middle East and Afric...

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    Oligonucleotide Synthesis Market Summary

    As per Market Research Future Analysis, the Oligonucleotide Synthesis Market was valued at 12.38 USD Billion in 2024 and is projected to grow to 58.89 USD Billion by 2035, reflecting a CAGR of 15.23% from 2025 to 2035. The market is driven by the rising demand for personalized medicine, advancements in gene therapy, and increased applications in diagnostics and therapeutics. Key players are focusing on innovative synthesis technologies to meet the growing needs in academia and pharmaceuticals.

    Key Market Trends & Highlights

    The Oligonucleotide Synthesis Market is witnessing significant growth driven by technological advancements and increasing applications.

    • Market Size in 2024: 12.38 USD Billion; Expected to reach 58.89 USD Billion by 2035.
    • CAGR from 2025 to 2035: 15.23%; driven by personalized medicine and gene therapy.
    • North America projected to dominate with a valuation of 2.15 USD Billion in 2024.
    • Diagnostics application is crucial, with the global diagnostics market expected to reach approximately 200 USD Billion by 2025.

    Market Size & Forecast

    2024 Market Size USD 12.38 Billion
    2035 Market Size USD 58.89 Billion
    CAGR (2025-2035) 15.23%

    Major Players

    Key players include Thermo Fisher Scientific, Bioneer, Integrated DNA Technologies, Synlogic, and LGC Biosearch Technologies.

    Oligonucleotide Synthesis Market Trends

    In the Global Oligonucleotide Synthesis Market, the market drivers are the demand for personalized medicine and other advancements in genetic research. The market is supported by an increased emphasis on gene therapy and the creation of novel biomoleculars. Furthermore, greater investment in biotechnology and pharmaceuticals is improving research activities.

     Ways that can be helpful, but are currently not being harnessed, include automated techniques of synthesis and improving delivery systems of oligonucleotides. Such development may result in less expensive methods and thus, oligonucleotide synthesis can be performed by more researchers and institutions.

    Recent trends show that more precise medical interventions have increased the demand for oligonucleotides in diagnostics and therapeutics. Adopting techniques such as CRISPR and other genome-editing technologies are also fueling the need for synthesized oligonucleotides as they are a prerequisite in a lot of clinical and research work. The market is growing rapidly as many governments and organizations focus their funding on genetic research, as well as custom-tailored treatments. 

    Also, the market is seeing more public-private partnerships which are often very useful for advancing the field of oligonucleotide synthesis. The Global Oligonucleotide Synthesis Market is very much likely to continue changing with the advancement of technology and the growing importance of genetics in medicine.

     

    The ongoing advancements in oligonucleotide synthesis technologies appear to be driving innovation in therapeutic applications, thereby enhancing the potential for personalized medicine.

    U.S. National Institutes of Health

    Oligonucleotide Synthesis Market Drivers

    Rising Demand for Personalized Medicine

    The Global Oligonucleotide Synthesis Market Industry experiences a notable surge in demand for personalized medicine, driven by advancements in genomics and biotechnology. As healthcare shifts towards tailored therapies, oligonucleotides play a crucial role in developing targeted treatments for various diseases, including cancer and genetic disorders. The market is projected to reach 5.36 USD Billion in 2024, reflecting the increasing investment in research and development. This trend is likely to continue, as personalized medicine is anticipated to become a cornerstone of modern healthcare, potentially doubling the market size to 10.2 USD Billion by 2035.

    Market Segment Insights

    Oligonucleotide Synthesis Market Product Type Insights

    The Global Oligonucleotide Synthesis Market is broadly categorized by Product Type, which includes DNA Oligonucleotides, RNA Oligonucleotides, Modified Oligonucleotides, and ASO Oligonucleotides. In 2024, the valuation of DNA Oligonucleotides stands at 2.0 USD Billion, which is projected to increase to 4.0 USD Billion by 2035, thus dominating the market with the majority holding due to its extensive applications in gene research, therapeutic development, and diagnostics. 

    Similarly, RNA Oligonucleotides are valued at 1.5 USD Billion in 2024 and are expected to grow to 3.0 USD Billion by 2035, underscoring their significant role in gene expression studies and RNA interference applications, thereby making them crucial for advancing molecular biology.

    Modified Oligonucleotides, valued at 1.0 USD Billion in 2024 with expectations of reaching 2.0 USD Billion in 2035, reflect increasing attention towards customizability and enhanced stability, which meet the diverse needs in Research and Development (R) as well as therapeutic areas. 

    Oligonucleotide Synthesis Market Application Insights

    The Global Oligonucleotide Synthesis Market, valued at 5.36 USD Billion in 2024, is experiencing a notable upward trend with a projected increase to 10.2 USD Billion by 2035. Within this market, the Application segment plays a vital role, encompassing areas such as Diagnostics, Therapeutics, Research and Development, and Gene Synthesis. The Diagnostics application is essential due to the growing emphasis on precision medicine, which requires accurate genetic testing methods.

     Therapeutics is also significant, driven by advancements in personalized treatment options and the ongoing demand for innovative therapies.The Research and Development aspect is crucial in fostering scientific discovery, supporting pharmaceutical and biotechnology innovations. 

    Gene Synthesis, meanwhile, is gaining traction as it underpins significant advancements in genetic engineering and synthetic biology. The Global Oligonucleotide Synthesis Market data highlights that each of these applications contributes to overall market growth, driven by the increasing need for advanced genomic tools and techniques. Market trends indicate a steady rise fueled by technological advancements and the expanding scope of oligonucleotide applications across different sectors, marking the segment as a cornerstone of the industry.

    Oligonucleotide Synthesis Market End User Insights

    The Global Oligonucleotide Synthesis Market has shown significant growth with a projected valuation of 5.36 USD Billion in 2024, expanding further by 2035. Within the End User segment, Pharmaceutical Companies play a crucial role, leveraging oligonucleotide synthesis for drug development, particularly in oncology and genetic disorders. 

    Biotechnology Companies also contribute notably as they utilize oligonucleotides for diagnostics and therapeutic solutions, creating innovative products that address unmet medical needs. Academic and Research Institutions are essential for advancing knowledge and driving scientific discovery in genetic research, benefiting the overall market significantly.

    Contract Research Organizations facilitate efficient development processes for pharmaceutical and biotechnology firms, allowing them to outsource oligonucleotide synthesis and focus on core competencies. The market is expected to benefit from trends such as the rising demand for personalized medicine, advancements in genomics research, and an increase in investments in biotechnology R However, challenges like high production costs and regulatory hurdles may impact growth.

    Oligonucleotide Synthesis Market Technology Insights

    The Technology segment of the Global Oligonucleotide Synthesis Market has emerged as a pivotal area, driven by advancements in various synthesis methods. By 2024, this market is set to reach a value of 5.36 billion USD, reflecting the growing need for precise nucleotide sequences in diverse applications such as Research and Development, diagnostics, and therapeutic development. 

    The market has been considerably influenced by the Solid-Phase Synthesis method, which is recognized for its efficiency and reliability in producing high-purity oligonucleotides, making it an essential technology in pharmaceutical and research settings.

    Liquid-Phase Synthesis complements this by providing flexibility in oligonucleotide production, particularly useful in large-scale manufacturing processes. 

    Get more detailed insights about Oligonucleotide Synthesis Market Research Report - Forecast till 2035

    Regional Insights

    The Global Oligonucleotide Synthesis Market has shown significant growth across various regions, with North America leading the charge. In 2024, North America is set to account for a valuation of 2.15 USD Billion, dominating the market due to its advanced biotechnology infrastructure and robust Research and Development initiatives. Europe follows with a valuation of 1.3 USD Billion in 2024, supported by a strong emphasis on genetic research and personalized medicine. 

    The Asia-Pacific region (APAC) is experiencing remarkable growth with a projected valuation of 1.15 USD Billion, largely driven by increasing investments in healthcare and biotechnology sectors, making it a significant competitor in the global market.

    South America's market value is 0.4 USD Billion, reflecting a growing acceptance of oligonucleotide applications, while the Middle East and Africa (MEA) region, valued at 0.36 USD Billion, shows potential for expansion in healthcare technologies. These regional dynamics highlight varying demand levels for oligonucleotide synthesis services, influenced by healthcare infrastructure, government policies, and technological advancements, illustrating the complexity and diversity within the Global Oligonucleotide Synthesis Market segmentation.

    Oligonucleotide Synthesis Market Region

    Key Players and Competitive Insights

    The Global Oligonucleotide Synthesis Market has become increasingly competitive as advancements in biotechnology and molecular biology drive demand for custom oligonucleotides used in a wide range of applications, from research to therapeutic development. Key players in this market are adopting various strategies such as partnerships, mergers, acquisitions, and technological innovations to enhance their service offerings and expand their market presence. 

    Companies are focusing on developing high-quality, cost-effective oligonucleotides to meet the growing needs of end-users in academia, pharmaceuticals, and diagnostics. The competitive landscape reflects a mix of established firms and innovative startups, each vying for a share of a market characterized by rapid growth and evolving customer requirements.

    Thermo Fisher Scientific holds a strong position in the Global Oligonucleotide Synthesis Market due to its commitment to quality and innovation. The company's extensive experience and technological expertise have enabled it to develop a robust portfolio of oligonucleotide synthesis products, catering to demands across various sectors. Their global presence is well-established, allowing them to deliver products efficiently to customers worldwide. 

    Thermo Fisher Scientific leverages its broad capabilities in life sciences, including reagents and instruments, to complement its oligonucleotide offerings, thus providing comprehensive solutions to researchers and laboratory professionals. The company's focus on customer support and service further strengthens its market position, ensuring that it remains a preferred choice for oligonucleotide synthesis amongst researchers and clinicians globally.

    Bioneer positions itself as a notable player in the Global Oligonucleotide Synthesis Market, focusing on providing a diverse range of high-quality oligonucleotide products and related services. The company has developed key offerings, including custom oligonucleotide synthesis, various modifications, and purification techniques that cater to the advanced research needs of scientific communities worldwide. Bioneer's competitive edge lies in its commitment to innovation and quality, coupled with its strategic partnerships and collaborations that enhance its market reach. 

    The company has made notable strides through mergers and acquisitions that allow it to diversify its product offerings and expand its technological capabilities. This strategic maneuvering, alongside a focus on customer-centric services, solidifies Bioneer's standing in the global marketplace, allowing it to effectively compete with larger players while addressing the specific needs of the global research community.

    Key Companies in the Oligonucleotide Synthesis Market market include

    Industry Developments

    • Q2 2024: Agilent Technologies Expands Oligonucleotide Manufacturing Facility in Frederick, Colorado Agilent Technologies announced the opening of a new manufacturing facility in Frederick, Colorado, to increase its capacity for therapeutic oligonucleotide production, supporting growing demand in the biopharmaceutical sector.
    • Q2 2024: Danaher Completes Acquisition of Aldevron, a Leader in Oligonucleotide and Plasmid DNA Manufacturing Danaher Corporation finalized its acquisition of Aldevron, expanding its capabilities in the production of oligonucleotides and other genetic medicines components.
    • Q3 2024: BioSpring Announces Construction of New Large-Scale Oligonucleotide Manufacturing Facility in Germany BioSpring revealed plans to build a new large-scale oligonucleotide synthesis facility in Frankfurt, Germany, to meet increasing demand for therapeutic and diagnostic oligos.
    • Q2 2024: Sarepta Therapeutics and Genevant Sciences Enter Strategic Partnership for Oligonucleotide Drug Delivery Sarepta Therapeutics and Genevant Sciences announced a partnership to co-develop novel delivery technologies for oligonucleotide-based therapeutics targeting rare diseases.
    • Q1 2025: Thermo Fisher Scientific Launches New High-Throughput Oligonucleotide Synthesis Platform Thermo Fisher Scientific introduced a new automated platform designed to accelerate high-throughput synthesis of custom oligonucleotides for research and clinical applications.
    • Q2 2025: Integrated DNA Technologies (IDT) Opens Expanded Oligonucleotide Manufacturing Facility in Iowa IDT announced the opening of an expanded manufacturing facility in Coralville, Iowa, increasing its production capacity for custom oligonucleotides to support global research and therapeutic markets.
    • Q2 2024: LGC Biosearch Technologies Secures Major Contract to Supply Oligonucleotides for Global Diagnostic Company LGC Biosearch Technologies won a multi-year contract to supply custom oligonucleotides for a leading global diagnostics company, supporting large-scale molecular testing.
    • Q3 2024: Nitto Denko Announces FDA Clearance for New Oligonucleotide API Manufacturing Facility in Ohio Nitto Denko received FDA clearance for its new oligonucleotide active pharmaceutical ingredient (API) manufacturing facility in Ohio, enabling commercial-scale production for therapeutic applications.
    • Q1 2025: Eurofins Genomics Launches Next-Generation Oligonucleotide Synthesis Service for mRNA Therapeutics Eurofins Genomics launched a new oligonucleotide synthesis service tailored for mRNA therapeutics, offering high-purity, large-scale custom oligos for pharmaceutical clients.
    • Q2 2025: Twist Bioscience Appoints New Chief Operating Officer to Oversee Oligonucleotide Manufacturing Expansion Twist Bioscience named a new COO to lead the company's ongoing expansion of its oligonucleotide manufacturing operations, aiming to meet rising demand in synthetic biology and therapeutics.
    • Q1 2024: Evonik Invests €25 Million in Oligonucleotide Production Facility in Germany Evonik announced a €25 million investment to expand its oligonucleotide production capabilities at its Hanau site, supporting pharmaceutical and biotech industry growth.
    • Q3 2024: Bachem and Eli Lilly Sign Long-Term Supply Agreement for Oligonucleotide Therapeutics Bachem entered a long-term supply agreement with Eli Lilly to provide oligonucleotide active pharmaceutical ingredients for Lilly’s pipeline of nucleic acid-based drugs.

    Future Outlook

    Oligonucleotide Synthesis Market Future Outlook

    The Global Oligonucleotide Synthesis Market is projected to grow at a 15.23% CAGR from 2025 to 2035, driven by advancements in personalized medicine, increasing R&D investments, and rising demand for synthetic biology applications.

    New opportunities lie in:

    • Develop novel oligonucleotide-based therapeutics targeting rare diseases. Invest in automation technologies to enhance synthesis efficiency and reduce costs. Expand product offerings to include custom oligonucleotides for emerging research applications.

    By 2035, the market is expected to demonstrate robust growth, solidifying its role in biotechnology and pharmaceuticals.

    Market Segmentation

    Oligonucleotide Synthesis Market End User Outlook

    • Pharmaceutical Companies
    • Biotechnology Companies
    • AcademicResearch Institutions
    • Contract Research Organizations

    Oligonucleotide Synthesis Market Regional Outlook

    • North America
    • Europe
    • South America
    • Asia Pacific
    • Middle East and Africa

    Oligonucleotide Synthesis Market Technology Outlook

    • Solid-Phase Synthesis
    • Liquid-Phase Synthesis
    • Microarray Technology

    Oligonucleotide Synthesis Market Application Outlook

    • Diagnostics
    • Therapeutics
    • ResearchDevelopment
    • Gene Synthesis

    Oligonucleotide Synthesis Market Product Type Outlook

    • DNA Oligonucleotides
    • RNA Oligonucleotides
    • Modified Oligonucleotides
    • ASO Oligonucleotides

    Report Scope

    Report Attribute/Metric Source: Details
    MARKET SIZE 2023 5.06(USD Billion)
    MARKET SIZE 2024 5.36(USD Billion)
    MARKET SIZE 2035 10.2(USD Billion)
    COMPOUND ANNUAL GROWTH RATE (CAGR) 15.23% (2025 - 2035)
    REPORT COVERAGE Revenue Forecast, Competitive Landscape, Growth Factors, and Trends
    BASE YEAR 2024
    MARKET FORECAST PERIOD 2025 - 2035
    HISTORICAL DATA 2019 - 2023
    MARKET FORECAST UNITS USD Billion
    KEY COMPANIES PROFILED Thermo Fisher Scientific, Bioneer, OncoOne, Integrated DNA Technologies, Synlogic, Biomatik, LGC Biosearch Technologies, GenScript, DNA2.0, Agilent Technologies, Eurofins Genomics, TriLink BioTechnologies, SigmaAldrich, General Electric
    SEGMENTS COVERED Product Type, Application, End User, Technology, Regional
    KEY MARKET OPPORTUNITIES Increased demand for personalized medicine, Growth in molecular diagnostics, Expansion of synthetic biology applications, Advancements in CRISPR technology, Rising investment in biotechnology research
    KEY MARKET DYNAMICS Rising demand for personalized medicine, Increasing applications in diagnostics, Advances in synthesis technologies, Growing biotechnology and pharmaceutical sectors, Expanding research activities in genomics
    COUNTRIES COVERED North America, Europe, APAC, South America, MEA
    Market Size 2024 12.38
    Market Size 2025 14.27
    Market Size 2035 58.89
    Base Year 2024
    Market Forecast Period 2025 - 2035

    Market Highlights

    Author
    Rahul Gotadki
    Assistant Manager

    He holds an experience of about 7+ years in Market Research and Business Consulting, working under the spectrum of Life Sciences and Healthcare domains. Rahul conceptualizes and implements a scalable business strategy and provides strategic leadership to the clients. His expertise lies in market estimation, competitive intelligence, pipeline analysis, customer assessment, etc. In addition to the above, his other responsibility includes strategic tracking of high growth markets & advising clients on the potential areas of focus they could direct their business initiatives

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    FAQs

    What is the expected market size of the Global Oligonucleotide Synthesis Market in 2024?

    The Global Oligonucleotide Synthesis Market is expected to be valued at 5.36 USD Billion in 2024.

    What will the market size of the Global Oligonucleotide Synthesis Market be by 2035?

    By 2035, the Global Oligonucleotide Synthesis Market is projected to reach 10.2 USD Billion.

    What is the expected compound annual growth rate (CAGR) of the market from 2025 to 2035?

    The Global Oligonucleotide Synthesis Market is expected to grow at a CAGR of 6.03% from 2025 to 2035.

    Which region holds the largest market share in the Global Oligonucleotide Synthesis Market in 2024?

    North America is expected to hold the largest market share at 2.15 USD Billion in 2024.

    What is the projected market size for Europe in the Global Oligonucleotide Synthesis Market by 2035?

    The market size for Europe is projected to be 2.5 USD Billion by 2035.

    Who are the key players in the Global Oligonucleotide Synthesis Market?

    Major players include Thermo Fisher Scientific, Integrated DNA Technologies, GenScript, and Agilent Technologies.

    What is the market size for RNA Oligonucleotides in 2024?

    The market for RNA Oligonucleotides is valued at 1.5 USD Billion in 2024.

    What is the expected growth rate for the Asia Pacific region from 2024 to 2035?

    The Asia Pacific region is expected to grow from 1.15 USD Billion in 2024 to 2.25 USD Billion by 2035.

    What is the projected market value for ASO Oligonucleotides in 2035?

    By 2035, the market value for ASO Oligonucleotides is expected to reach 1.2 USD Billion.

    What challenges might affect the growth of the Global Oligonucleotide Synthesis Market?

    Challenges may include regulatory hurdles and competition among key players in the industry.

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